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    For Research Use Only. Not For Clinical Use.


    The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
    Protein class

    Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Langerhans cells)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Cell line enhanced (MOLT-4)

    Interaction

    Interacts with ATAD5. Interacts with PRMT2, CDK1 and CDK2 (By similarity). The hypophosphorylated form interacts with and sequesters the E2F1 transcription factor (PubMed:8336704, PubMed:20940255). Interacts with heterodimeric E2F/DP transcription factor complexes containing TFDP1 and either E2F1, E2F3, E2F4 or E2F5, or TFDP2 and E2F4. The unphosphorylated form interacts with EID1, ARID3B, KDM5A, SUV39H1, MJD2A/JHDM3A and THOC1. Interacts with the N-terminal domain of TAF1. Interacts with SNW1, AATF, DNMT1, LIN9, LMNA, KMT5B, KMT5C, PELP1, UHRF2 and TMPO-alpha. May interact with NDC80. Interacts with GRIP1 and UBR4. Interacts with ARID4A and KDM5B. Interacts with E4F1 and LIMD1. Interacts with SMARCA4/BRG1 AND HDAC1 (By similarity). Interacts with PSMA3 and USP4. Interacts (when methylated at Lys-860) with L3MBTL1. Interacts with CHEK2; phosphorylates RB1. Interacts with CEBPA (PubMed:15107404). P-TEFB complex interacts with RB1; promotes phosphorylation of RB1 (PubMed:12037672). Interacts with RBBP9; the interaction disrupts RB1 binding to E2F1 (By similarity). Interacts with KAT2B/PCAF and EP300/P300 (By similarity). Interacts with PAX5 (PubMed:10197586). (Microbial infection) Interacts with adenovirus E1A protein. (Microbial infection) Interacts with HPV E7 protein. (Microbial infection) Interacts with SV40 large T antigen. (Microbial infection) Interacts with human cytomegalovirus/HHV-5 proteins UL82 and UL123. (Microbial infection) Interacts with molluscum contagiosum virus protein MC007.

    Molecular function

    Chromatin regulator, DNA-binding, Repressor

    More Types Infomation
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