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RGMB
Loading...Anti-RGMB Products
- Rat Anti-RGMB Recombinant Antibody (HPAB-0222-YJ) (HPAB-0222-YJ)
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- Species Reactivity: Human, Mouse
- Type: Rat IgG, κ
- Application: ELISA, FC, Block, IF, FuncS
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- Rat Anti-RGMB Recombinant Antibody; scFv Fragment (HPAB-0222-YJ-S(P)) (HPAB-0222-YJ-S(P))
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- Species Reactivity: Human, Mouse
- Type: Rat scFv
- Application: ELISA, Block, FC, IF, Inhib
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- Rat Anti-RGMB Recombinant Antibody; Fab Fragment (HPAB-0222-YJ-F(E)) (HPAB-0222-YJ-F(E))
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- Species Reactivity: Human, Mouse
- Type: Rat Fab
- Application: ELISA, Block, FC, IF, Inhib
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Undifferentiated cells, Early spermatids)
Immune cell specificity
Immune cell enhanced (naive CD4 T-cell)
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, HBF TERT88, LHCN-M2)
Interaction
Homooligomer (By similarity). Interacts with DRGX (By similarity). Interacts with BMP2 and BMP4 (By similarity). Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B (By similarity). The functional complex with its receptor NEO1/neogenin appears to be a heterotetramer with a 2:2 stoichiometry, RGM molecules acting as staples that bring two NEO1 receptors together without interacting themselves, this arrangement leads to activation of downstream signaling via RhoA.
More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway