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RGMB
Loading...Anti-RGMB Products
- Rat Anti-RGMB Recombinant Antibody (HPAB-0222-YJ) (HPAB-0222-YJ)
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- Species Reactivity: Human, Mouse
- Type: Rat IgG, κ
- Application: ELISA, FC, Block, IF, FuncS
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- Rat Anti-RGMB Recombinant Antibody; scFv Fragment (HPAB-0222-YJ-S(P)) (HPAB-0222-YJ-S(P))
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- Species Reactivity: Human, Mouse
- Type: Rat scFv
- Application: ELISA, Block, FC, IF, Inhib
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- Rat Anti-RGMB Recombinant Antibody; Fab Fragment (HPAB-0222-YJ-F(E)) (HPAB-0222-YJ-F(E))
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- Species Reactivity: Human, Mouse
- Type: Rat Fab
- Application: ELISA, Block, FC, IF, Inhib
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For Research Use Only. Not For Clinical Use.
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Undifferentiated cells, Early spermatids)
Immune cell specificity
Immune cell enhanced (naive CD4 T-cell)
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, HBF TERT88, LHCN-M2)
Interaction
Homooligomer (By similarity). Interacts with DRGX (By similarity). Interacts with BMP2 and BMP4 (By similarity). Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B (By similarity). The functional complex with its receptor NEO1/neogenin appears to be a heterotetramer with a 2:2 stoichiometry, RGM molecules acting as staples that bring two NEO1 receptors together without interacting themselves, this arrangement leads to activation of downstream signaling via RhoA.
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Related Signaling Pathways
TGF-β Signaling Pathway