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RGMB
Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system. RGMB acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling. It promotes neuronal adhesion. RGMB may inhibit neurite outgrowth.
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Undifferentiated cells, Early spermatids)
Immune cell specificity
Immune cell enhanced (naive CD4 T-cell)
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, HBF TERT88, LHCN-M2)
Interaction
Homooligomer (By similarity). Interacts with DRGX (By similarity). Interacts with BMP2 and BMP4 (By similarity). Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B (By similarity). The functional complex with its receptor NEO1/neogenin appears to be a heterotetramer with a 2:2 stoichiometry, RGM molecules acting as staples that bring two NEO1 receptors together without interacting themselves, this arrangement leads to activation of downstream signaling via RhoA.
More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway
- Rat Anti-RGMB Recombinant Antibody; Fab Fragment (HPAB-0222-YJ-F(E)) (HPAB-0222-YJ-F(E))
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- Species Reactivity: Human, Mouse
- Type: Rat Fab
- Application: ELISA, Block, FC, IF, Inhib
- Rat Anti-RGMB Recombinant Antibody; scFv Fragment (HPAB-0222-YJ-S(P)) (HPAB-0222-YJ-S(P))
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- Species Reactivity: Human, Mouse
- Type: Rat scFv
- Application: ELISA, Block, FC, IF, Inhib
- Rat Anti-RGMB Recombinant Antibody (HPAB-0222-YJ) (HPAB-0222-YJ)
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- Species Reactivity: Human, Mouse
- Type: Rat IgG, κ
- Application: ELISA, FC, Block, IF, FuncS
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For Research Use Only. Not For Clinical Use.