Anti-Human PDCD1 Therapeutic Antibody (CAT#: TAB-H55)

Recombinant Humanized (from mouse) antibody to Human PDCD1. It is a drug that targets the programmed cell death 1 (PD-1) receptor. The drug is intended for use in treating metastatic melanoma.

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Inhib

Figure 1 Anti-PDCD1 treatment has significant therapeutic activity against central nervous system lymphoma in an immunocompetent A20 model.

Murine anti-PDCD1 was administered intraperitoneally weekly at 200 ug for 7 weeks, starting at day 8 post-implantation. Anti-PDCD1 treatment had significant impact on tumour growth.

Qiu, Y., Li, Z., Pouzoulet, F., Vishnu, P., Copland III, J. A., Knutson, K. L., ... & Tun, H. W. (2018). Immune checkpoint inhibition by anti‐PDCD 1 (anti‐PD 1) monoclonal antibody has significant therapeutic activity against central nervous system lymphoma in an immunocompetent preclinical model. British journal of haematology, 183(4), 674-678.

Agonist

Figure 2 Anti-PDCD1 treatment results in significantly increased infiltration of brain tumour as well as non‐tumour bearing brain by CD8+ lymphocytes in immunocompetent A20 central nervous system lymphoma model.

Immunohistochemistry shows a significant increase in CD8⁺ lymphocyte infiltration of the tumour and the non‐tumour bearing contralateral brain with anti‐PDCD1 treatment compared to no‐treatment control (40×magnification for tumour; 20× magnification for contralateral brain).

Qiu, Y., Li, Z., Pouzoulet, F., Vishnu, P., Copland III, J. A., Knutson, K. L., ... & Tun, H. W. (2018). Immune checkpoint inhibition by anti‐PDCD 1 (anti‐PD 1) monoclonal antibody has significant therapeutic activity against central nervous system lymphoma in an immunocompetent preclinical model. British journal of haematology, 183(4), 674-678.


Specifications

  • Host Species
  • Mouse
  • Derivation
  • Humanized (from mouse)
  • Type
  • IgG4 - kappa
  • Specificity
  • PDCD1(programmed cell death 1, PD-1, PD1, CD279) [Homo sapiens]
  • Species Reactivity
  • Human
  • Applications
  • Inhib, Agonist
  • CAS
  • 1374853-91-4
  • MW
  • 146.3 kDa
  • Related Disease
  • Solid tumors

Applications

  • Application Notes
  • The Human PDCD1 antibody has been reported in applications of Inhibition, Agonist.
    Inhib: 200 ug.

Target

  • Alternative Names
  • pembrolizumab;1374853-91-4;MK-3475;SCH 900475;lambrolizumab;MK-3475; lambrolizumab;PDCD1;programmed cell death 1;programmed cell death protein 1;CD279;PD1;protein PD-1;PD-1;SLEB2;hPD-1;hPD-l;

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Resources

Please click here for more details about the introduction to mechanism of action, clinical projects and approved drugs of Pembrolizumab.

See other products for "PDCD1"

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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