PE-B*51:01/Human PMEL (LPDGQVIWV) MHC Tetramer

Name: PE-B*51:01/Human PMEL (LPDGQVIWV) MHC Tetramer
SKU: MHC-LC2487
Rating: 5 (1 reviews)

CAT#: MHC-LC2487

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human PMEL of peptide LPDGQVIWV covering 97-105 and B*51:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line SK-MEL-30

Immunofluorescent staining of human cell line SK-MEL-30 shows localization to endoplasmic reticulum & the Golgi apparatus.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/1898_C6_19_cr5ba8a6f6e250d_selected.jpg

Normal Tissue Figure 2 Kidney

Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_A_7_5.jpg

Normal Tissue Figure 3 Testis

Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_A_4_6.jpg

Normal Tissue Figure 4 Skin

Melanocytes
Staining:High
Intensity: Strong
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_B_7_1.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enriched (SK-MEL-30)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185664-PMEL

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Specifications

Allele
B*51:01

Class
Class I

MHC Species
Human

Antigen
PMEL

Antigen Species
Human

Peptide
LPDGQVIWV

Range
97-105

Conjugate
PE

Application
FCM

Target

Antigen Introduction
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]

Alternative Names
PMEL; Melanocyte protein Pmel 17 precursor; P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E

Gene ID
6490

UniProt ID
P40967

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Datasheet

Datasheet - MHC-LC2487.pdf

MSDS

MSDS - MHC-LC2487.pdf

COA

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