Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)

Name: Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)
SKU: Gly-138LC
Rating: 5 (1 reviews)

CAT#: Gly-138LC

This product is a non-fucosylated humanized monoclonal antibody. The antibody 2H7.v511 with enhanced ADCC specficfically binds to human CD20 and can be potentially used in the treatment of cancer and autoimmune disease.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line REH

Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg

Normal Tissue Figure 4 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg

Normal Tissue Figure 5 Bone marrow

Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (Daudi, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1

❮

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Glyco-engineering

Glycosylation site
Asn297 in Fc region

Glycosylation Type
N-glycosylation

Activity
Enhanced ADCC

Specifications

Target
CD20 (Cluster of differentiation-20)

Host Species
Human

Type
Humanized antibody

Specificity
Human

Antibody Isotype
IgG1

Clone
2H7.v511

Expression Host
CHO

Applications
ELISA

Target

Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1;

Related Disease
Cancer and autoimmune disease

Gene ID
931

UniProt ID
A0A024R507

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Downloadable Resources

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Datasheet

Datasheet - Gly-138LC.pdf

MSDS

MSDS - Gly-138LC.pdf

COA

Certificate of Analysis Lookup

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