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    Human Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC138), CDC Enhanced (CAT#: VS-0924-YC138)

    The product is a human anti-MS4A1 antibody designed as a hexamer to enhance CDC activity. This hexameric IgG1 targets human MS4A1 and features hexamerization-enhancing mutations that promote the formation of hexamers. This structural adaptation improves C1q binding and optimizes complement-dependent cytotoxicity (CDC).

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Fc Engineering:

    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line REH
    Figure 1 IF staining of human cell line REH
    (Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg
    Figure 2 IF staining of human cell line A-431
    Figure 2 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg
    Figure 3 IF staining of human cell line U-2 OS
    Figure 3 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg
    Normal Tissue
    Figure 4 Colon
    Figure 4 Colon
    (Mucosal lymphoid cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg
    Figure 5 Bone marrow
    Figure 5 Bone marrow
    (Hematopoietic cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg
    Figure 6 Lymph node
    Figure 6 Lymph node
    (Germinal center cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg
    RNA Expression
    Figure 7 RNA cell line category: Group enriched (Daudi, U-698)
    Figure 7 RNA cell line category: Group enriched (Daudi, U-698)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1

    Specifications

    • Immunogen
    • Human CD20 transfected NS/0 cells
    • Host Species
    • Human
    • Type
    • Antibody hexamer
    • Specificity
    • Human MS4A1
    • Species Reactivity
    • Human
    • Molecule Class
    • ~ 900 kDa
    • Applications
    • FC, CDC, IP
    • Conjugate
    • None
    • Related Disease
    • Diseases associated with cells expressing CD20 (including tumor-related diseases) and immune diseases (including autoimmune diseases)

    Product Property

    • Clonality
    • Monoclonal
    • Purification
    • Protein A purified
    • Purity
    • >95% determined as SDS-PAGE and SEC-HPLC
    • Aggregation
    • <5%
    • Buffer
    • PBS, pH 7.4
    • Preservative
    • No preservatives
    • Storage
    • Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-1
    • Long Name
    • Membrane Spanning 4-Domains A1

    Downloads

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    See other products for "MS4A1"

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    CAT Product Name Application Type
    TAB-H51 Anti-Human MS4A1 Recombinant Antibody (TAB-H51) FC, Inhib IgG1 - kappa
    TAB-1635CL-S(P) Anti-Human MS4A1 Recombinant Antibody scFv Fragment (BVX20) Inhib Humanized antibody
    TAB-1636CL-S(P) Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1636CL-S(P)) ADCC, CDC Humanized scFv
    TAB-1637CL-S(P) Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1637CL-S(P)) ADCC, CDC Humanized scFv
    TAB-1638CL-S(P) Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1638CL-S(P)) ADCC, CDC Humanized scFv

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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