Anti-Human MS4A1 Recombinant Antibody (1.5.3)

Name: Anti-Human MS4A1 Recombinant Antibody (1.5.3)
SKU: TAB-1647CL
Rating: 5 (1 reviews)

CAT#: TAB-1647CL

This antibody 1.5.3 targets the antigen CD20. Clone 1.5.3 is useful for inhibiting the growth of cells that express CD20. Clone 1.5.3 mediated significantly higher levels of cell lysis in Karpas-422 cell lines and EHEB cell lines.

Published Data Gene Expression

FuncS

Figure 1 shows the results of cell viability assays without cross-linking of Ramos cells incubated with the antibody, and the Rituxan® ("Rituximab") antibody control.

Percent viability of Ramos cells is shown on the y-axis and antibody concentration is shown on the x-axis.

FuncS

Figure 2 shows the results of Annexin V/PI apoptosis assays without cross-linker of Ramos cells incubated with mAbs.

Rituximab and Bl. % viability is shown on the y-axis and antibody concentration is on the x-axis.

Cyt

Figure 3 shows the results of CDC assays of Ramos cell lines, respectively, incubated with mAbs.

Cyt

Figure 4 is a graph shows results of an ADCC assay of Ramos cell line incubated with mAbs 2.1.2, 1.1-2, 1.5.3, 1.10.3.1, and 1.11.3.1, Rituximab, and IgGl control. % viability is showsn on the y-axis and antibody concentration is showsn on the x-axis.

FuncS

Figure 5 is a line graph shows the effect of anti-CD20 antibodies, Rituximab, 2.1.2, 1.1.2, and 1.5.3 on mouse survival in a Ramos i.v. paralysis model (CB 17 SCID).

The results show that three anti-CD20 antibodies demonstrate potent anti- lymphoma activity when administered as a single dose monotherapy. The number of days of treatment post tumor cell implantation is shown on the x-axis and percent survival is shown on the y-axis.

FuncS

Figure 6 is a line graph shows the efficacy of anti-CD20 antibodies in the Daudi subcutaneous tumor model.

The number of days of treatment after the time of tumor cell inoculation is shown on the x-axis and tumor volume in cubic millimeters is shown on the y-axis.

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Subcellular Location and Protein Expression Figure 1 IF staining of human cell line REH

Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg

Normal Tissue Figure 4 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg

Normal Tissue Figure 5 Bone marrow

Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (Daudi, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1

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Specifications

Immunogen
CD20 expressed in human cancer cell lines Ramos, Daudi and CD20- CHO cells

Host Species
Human

Type
Fully human antibody

Specificity
Human

Clone
1.5.3

Applications
Cyt, FuncS

Related Disease
Neoplastic disease

Applications

Application Notes
This antibody has been reported for use in Cytotoxicity, Functional Assay.

Target

Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-1

Gene ID
931

UniProt ID
P11836

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-1647CL.pdf

MSDS

MSDS - TAB-1647CL.pdf

COA

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TAB-1637CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1637CL)	ADCC, CDC	Humanized IgG
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Gly-138LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
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Gly-158LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)

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Gly-142LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-155LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated)	ELISA	Humanized antibody

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HPAB-0247-FY-S(P)	Human Anti-MS4A1 Recombinant Antibody scFv Fragment (HPAB-0247-FY-S(P))	Inhib, ELISA	Humanized scFv
HPAB-0614-WJ-S(P)	Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-0614-WJ-S(P))	ELISA, FC	Mouse scFv
HPAB-0615-WJ-S(P)	Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-0615-WJ-S(P))	ELISA, FC	Mouse scFv
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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