Anti-Human CD20 Recombinant Antibody (Afutuzumab) (CAT#: TAB-133)
Recombinant monoclonal antibody to CD20. Afutuzumab is a monoclonal antibody for the treatment of lymphoma. It acts as an immunomodulator.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line REH
(Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg
(Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg
Figure 4 Colon
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg
Figure 5 Bone marrow
(Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg
(Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg
Figure 6 Lymph node
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg
Figure 7 RNA cell line category: Group enriched (Daudi, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG3 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
- Trade name
- obinutuzumab, obinutuzumab
- CAS
- 949142-50-1
- Generic Name
- Afutuzumab
- ATC Code
- L01XC15
- UNII
- O43472U9X8
- MW
- 146.1 kDa
Product Property
- Purity
- >95%, by SDS-PAGE with silver staining, under reducing conditions.
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Target
- Alternative Names
- Afutuzumab;obinutuzumab, obinutuzumabro;949142-50-1;Obinutuzumab;obinutuzumab;obinutuzumabro ;MS4A1;membrane-spanning 4-domains, subfamily A, member 1;CD20;B-lymphocyte antigen CD20;B1;Bp35;CD20 antigen;CD20 receptor;leukocyte surface antigen Leu-16;B-lymphocyte cell-surfa
- Gene ID
- 931
- UniProt ID
- P11836
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Afutuzumab"
Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-133)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD20. It is a monoclonal antibody for the treatment of lymphoma. It acts as an immunomodulator.
See other products for "MS4A1"
Select a product category from the dropdown menu below to view related products.
Please select product type
Chimeric Antibody Products
Humanized Antibody Products
Human Antibody Products
Mouse Antibody Products
Fc Glycosylation Antibody Products
Low- or Non-fucosylated Oligosaccharide Antibody Products
Hyper-galactosylated Antibody Products
High-mannose Glycoform Antibody Products
Deglycosylated Antibody Products
MHC Tetramer Products for Cancer
Neutralizing Antibody Products
Rabbit Monoclonal Antibody Products
ScFv Antibody Products
Fab Antibody Products
Single Domain Antibody Products
ADCC Enhanced Antibody Products
IgG Antibody Products
Antibody Magnetic Beads
Hexamer Antibody Products
Non-Human Primate (NHP) Antibody Products
ScFv-Fc Chimera Products
Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-207 | Anti-Human CD20 Recombinant Antibody | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
| TAB-1633CL | Anti-Human MS4A1 Recombinant Antibody (ch1F5) | FC, Apop, CDC, ADCC, Inhib | Chimeric antibody (mouse/human) |
| TAB-1634CL | Anti-Human MS4A1 Recombinant Antibody (ch1F5-DXL) | FC, Apop, CDC, ADCC, Inhib | Chimeric antibody (mouse/human) |
| TAB-1656CL | Anti-Human MS4A1 Recombinant Antibody (ch2B8) | FC, CMCD, ADCC, Activ, Inhib, Depletion | Chimeric antibody (mouse/human) |
| TAB-1665CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1665CL) | CDC | Chimeric (mouse/human) IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for TAB-133. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: WB, IHC, FC, Cyt, ELISA
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, FC, Inhib, FuncS
Application: ELISA, WB, FC, IHC, IP
Application: ELISA, IF, Block, FuncS
Application: ELISA, WB
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
