Anti-MS4A1 Antibody Prodrug, Protease Activated (Rituximab)

Name: Anti-MS4A1 Antibody Prodrug, Protease Activated (Rituximab)
SKU: VS-1025-YC1
Rating: 5 (1 reviews)

CAT#: VS-1025-YC1

The Anti-MS4A1 Antibody Prodrug, Protease Activated (Rituximab) is an antibody prodrug comprised of a recombinant mouse antibody targeting human CD20, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to MS4A1 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to MS4A1 effectively. CD20 is a cell-surface protein universally expressed on B-cells, and critically, on the majority of B-cell non-Hodgkin lymphomas and leukemias. Its presence makes it an established biomarker and therapeutic target in these hematological malignancies. The anti-CD20 monoclonal antibody rituximab specifically targets this protein, leading to the destruction of the malignant B-cells and serving as a backbone of modern lymphoma treatment.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line REH

Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg

Normal Tissue Figure 4 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg

Normal Tissue Figure 5 Bone marrow

Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (Daudi, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1

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Specifications

Host Animal
Mouse

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human CD20

Target
MS4A1

Species Reactivity
Human

Isotype
IgG1, kappa

Clone
Rituximab

Masking Approach
Steric mask

Mask
Coiled-coiled domains

Purification
Protein G purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
CD20 is B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells.

Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; CD20; B-lymphocyte antigen CD20; B1; Bp35; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16

Gene ID
931

UniProt ID
P11836

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Downloadable Resources

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Datasheet

Datasheet - VS-1025-YC1.pdf

MSDS

MSDS - VS-1025-YC1.pdf

COA

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HPAB-M0704-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0704-YC)	ELISA, FuncS	Camelid VHH
HPAB-M0705-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0705-YC)	ELISA	Camelid VHH
HPAB-M0706-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0706-YC)	ELISA	Camelid VHH
HPAB-M0707-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0707-YC)	ELISA	Camelid VHH

CAT	Product Name	Application	Type
TAB-772	Human Anti-MS4A1 Recombinant Antibody (TAB-772)	ELISA, IP, FC, FuncS, Neut, IF, ICC	IgG1
TAB-771	Humanized Anti-MS4A1 Recombinant Antibody (TAB-771)	IF, IP, Neut, FuncS, ELISA, FC, ICC	Humanized IgG1, κ
TAB-H51	Anti-Human MS4A1 Recombinant Antibody (TAB-H51)	FC, Inhib	IgG1 - kappa
TAB-133	Anti-Human CD20 Recombinant Antibody (Afutuzumab)	IP, IF, FuncS, FC, Neut, ELISA, ICC	IgG3 - kappa
TAB-537CL	Human Anti-MS4A1 Recombinant Antibody (TAB-537CL)	ELISA	Human IgG

CAT	Product Name	Application	Type
TAB-016	Anti-Human CD20 Recombinant Antibody (Rituximab)	IF, IP, Neut, FuncS, ELISA, FC, WB	IgG1 - kappa
TAB-207	Anti-Human CD20 Recombinant Antibody	ELISA, IP, FC, FuncS, Neut, IF, ICC	IgG1 - kappa
TAB-1633CL	Anti-Human MS4A1 Recombinant Antibody (ch1F5)	FC, Apop, CDC, ADCC, Inhib	Chimeric antibody (mouse/human)
TAB-1634CL	Anti-Human MS4A1 Recombinant Antibody (ch1F5-DXL)	FC, Apop, CDC, ADCC, Inhib	Chimeric antibody (mouse/human)
TAB-1656CL	Anti-Human MS4A1 Recombinant Antibody (ch2B8)	FC, CMCD, ADCC, Activ, Inhib, Depletion	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
TAB-028	Anti-Human CD20 Recombinant Antibody (TAB-028)	FC, IP, ELISA, Neut, FuncS, IF, IHC	IgG1 - kappa
TAB-0001CL	Human Anti-MS4A1 Recombinant Antibody (TAB-0001CL)	ELISA, ADCC, CDC	Human IgG
TAB-1645CL	Anti-Human MS4A1 Recombinant Antibody (2.1.2)	Cyt, FuncS	Fully human antibody
TAB-1646CL	Anti-Human MS4A1 Recombinant Antibody (1.1.2)	Cyt, FuncS	Fully human antibody
TAB-1647CL	Anti-Human MS4A1 Recombinant Antibody (1.5.3)	Cyt, FuncS	Fully human antibody

CAT	Product Name	Application	Type
TAB-017	Anti-Human CD20 Recombinant Antibody (TAB-017)	Neut, ELISA, IF, IP, FuncS, FC, ICC	IgG2a - lambda
TAB-711	Anti-MS4A1 Recombinant Antibody (Technetium (99MTC) Nofetumomab Merpentan)	FC, IP, ELISA, Neut, FuncS, IF, ICC	Fab - G2b - kappa
TAB-001	Anti-Human CD20 Recombinant Antibody (Ibritumomab)	ELISA, IP, FC, FuncS, IF, Neut	IgG1 - kappa
TAB-H27	Anti-Human MS4A1 Recombinant Antibody (Epitumomab)	IP, IF, FuncS, FC, Neut, ELISA, ICC	IgG2a
TAB-H39	Anti-Human MS4A1 Recombinant Antibody (Ibritumomab)	FC, IP, ELISA, Neut, FuncS, IF, ICC	Mouse IgG1 - kappa

CAT	Product Name	Application	Type
PABW-019	Human Anti-MS4A1 Recombinant Antibody (clone C2H7)	WB, IF, FuncS	Chimeric (mouse/human) IgG
PABZ-143	Human Anti-MS4A1 Recombinant Antibody (clone KM3575)	WB	Chimeric (mouse/human) IgG1, κ
PABL-422	Human Anti-MS4A1 Recombinant Antibody (clone 2F2)	WB, ELISA, FuncS	Human IgG1,κ
PABL-423	Mouse Anti-MS4A1 Recombinant Antibody (clone GA101)	FC, Activ, Agonist, IF, WB, Cyt, FuncS	Mouse IgG
MOB-0279MZ	Mouse Anti-MS4A1 Recombinant Antibody (clone M27 (1, 4).)	IHC	Mouse IgG2a

CAT	Product Name	Application	Type
PFBW-019	Human Anti-MS4A1 Recombinant Antibody (clone C2H7); Fab Fragment	WB, IF, FuncS	Chimeric (mouse/human) IgG
PFBL-419	Human Anti-MS4A1 Recombinant Antibody (clone 2F2); Fab Fragment	WB, ELISA, FuncS	Human Fab
PFBL-420	Mouse Anti-MS4A1 Recombinant Antibody (clone GA101); Fab Fragment	WB, ELISA, FuncS	Mouse Fab
PSBZ-143	Mouse Anti-MS4A1 Recombinant Antibody (clone KM3575); scFv Fragment	WB	Mouse scFv
FAMAB-0241CQ-F(E)	Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7); Fab Fragment	ELISA, FC, IHC, IP	Mouse Fab

CAT	Product Name	Application	Type
PFBZ-143	Human Anti-MS4A1 Recombinant Antibody (clone KM3575); Fab Fragment	WB	Chimeric (mouse/human) Fab
PSBW-019	Mouse Anti-MS4A1 Recombinant Antibody (clone C2H7); scFv Fragment	WB, IF, FuncS	Mouse scFv
PSBL-419	Human Anti-MS4A1 Recombinant Antibody (clone 2F2); scFv Fragment	WB, ELISA, FuncS	Human scFv
PSBL-420	Mouse Anti-MS4A1 Recombinant Antibody (clone GA101); scFv Fragment	WB, ELISA, FuncS	Mouse scFv
FAMAB-0241CQ-S(P)	Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7); scFv Fragment	ELISA, FC, IHC, IP	Mouse scFv

CAT	Product Name	Application	Type
Gly-059LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Chimeric antibody (mouse/human)
Gly-063LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)
Gly-097LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Chimeric antibody (mouse/human)
Gly-115LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Humanized antibody
Gly-138LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-063LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)
Gly-134LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-135LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-136LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-137LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-142LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-155LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-171LC	Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application
MHC-LC066	PE-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
MHC-LC067	APC-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
MHC-LC068	BV421-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
MHC-LC4347	PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer	FCM

CAT	Product Name	Application	Type
NEUT-1751CQ	Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211)	Neut, FuncS	Mouse IgG1, κ

CAT	Product Name	Application	Type
MOR-2295	Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB)	IHC-Fr, IHC-P	Rabbit IgG
MOR-4024	Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS)	FC	Rabbit IgG

CAT	Product Name	Application	Type
AFC-TAB-772	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-772)	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody
AFC-TAB-016	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-016)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-028	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-028)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody
AFC-TAB-207	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-207)	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody
AFC-TAB-771	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-771)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0424-XY188	AbPlus™ Anti-MS4A1 Magnetic Beads (VS-0424-XY188)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0924-YC138	Human Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC138), CDC Enhanced	FC, CDC, IP	Antibody hexamer
VS-0924-YC139	Mouse Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC139), CDC Enhanced	FC, Activ, Agonist, IF, WB, Cyt, CDC	Antibody hexamer

CAT	Product Name	Application	Type
VS-1024-XY85	Mouse Anti-NHP MS4A1 Recombinant Antibody (VS-1024-XY85)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0125-FY30	Human Anti-MS4A1 (clone RW005) scFv-Fc Chimera	FuncS	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY168	CytoStream™ Rat Anti-MS4A1 Recombinant Antibody (clone GOT214A)	FC	Rat IgG2a, kappa

CAT	Product Name	Application	Type
VS-0425-YC513	Recombinant Anti-MS4A1 Vesicular Antibody, EV Displayed (VS-0425-YC513)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY4510	Anti-MS4A1 Immunohistochemistry Kit	IHC
VS-0525-XY4511	Anti-Mouse MS4A1 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC129	Recombinant Anti-MS4A1 (Bin I x Bin II) Biparatopic Antibody, Tandem scFv	ELISA, FC	Tandem scFv
VS-0525-YC222	Recombinant Anti-MS4A1 Biparatopic Antibody, Tandem scFv	ELISA, IF, WB	Tandem scFv

CAT	Product Name	Application	Type
VS-0825-YC17	SmartAb™ Recombinant Anti-MS4A1 pH-dependent Antibody (VS-0825-YC17)	FC, Inhib	Human IgG1 kappa
VS-0825-YC257	SmartAb™ Recombinant Anti-MS4A1 pH-dependent Antibody (Clone Rituximab)	IF, IP, Neut, ELISA, FC, WB	Human IgG1 kappa

CAT	Product Name	Application	Type
VS-1025-YC158	Anti-MS4A1 Antibody Prodrug, Protease Activated (2H7)	ISZ, Cyt, FuncS

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