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MS4A1

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This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.

Derivation:
Chimeric (mouse/human)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IF, IP, Neut, FuncS, ELISA, FC, WB
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
ELISA, FC, IP, FuncS, IF, Neut, WB
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
FC, IP, ELISA, Neut, FuncS, IF, IHC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1
Application:
Neut, ELISA, IF, IP, FuncS, FC, ICC
Derivation:
Chimeric (mouse/human)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
ELISA, IP, FC, FuncS, Neut, IF, ICC
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG2a - lambda
Application:
Neut, ELISA, IF, IP, FuncS, FC, ICC
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab - G2b - kappa
Application:
FC, IP, ELISA, Neut, FuncS, IF, ICC
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
ELISA, IP, FC, FuncS, IF, Neut
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG2a
Application:
IP, IF, FuncS, FC, Neut, ELISA, ICC
Species Reactivity:
Human
Type:
Llama VHH
Application:
IP, FC, ChiP, Neut
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1
Application:
ELISA, IP, FC, FuncS, Neut, IF, ICC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IF, IP, Neut, FuncS, ELISA, FC, ICC
Species Reactivity:
Human
Type:
IgG
Target:
CD20
Linker:
CL2A
Drug:
SN-38 (7-ethyl-10-hydroxycamptothecin)
Target:
CD20
Linker:
CL2E
Drug:
SN-38 (7-ethyl-10-hydroxycamptothecin)
Target:
CD20
Linker:
VC (valine-citrulline)
Drug:
MMAE (Monomethyl auristatin E)
Target:
CD20
Linker:
VC (valine-citrulline)
Drug:
MMAE (Monomethyl auristatin E)
Target:
CD20
Linker:
N-(2-Hydroxypropyl)methacrylamide (HPMA)
Target:
CD20
Linker:
mcc (Maleimidomethyl cyclohexane-1-carboxylate)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
CD20
Linker:
SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
Drug:
DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
Target:
CD20
Linker:
MCC (Maleimidomethyl cyclohexane-1-carboxylate)
Drug:
DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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