Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-771)

Name: Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-771)
SKU: AFC-TAB-771
Rating: 5 (1 reviews)

CAT#: AFC-TAB-771

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized antibody expressed in CHO binding to human MS4A1/CD20. It is a humanized monoclonal antibody designed for the treatment of cancer and autoimmune disorders. The antibody is engineered for enhanced affinity to the CD20 antigen on B-lymphocytes, increased antibody-dependent cell-mediated cytotoxicity (ADCC), and for improved treatment of low-affinity FcγRIIIa allotypes.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line REH

Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg

Normal Tissue Figure 4 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg

Normal Tissue Figure 5 Bone marrow

Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (Daudi, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Humanized (from mouse)

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
IF, IP, Neut, FuncS, ELISA, FC

Conjugate
Unconjugated

Generic Name
Ocaratuzumab

Related Disease
Non-Hodgkin's lymphoma (NHL)

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; CD20; B-lymphocyte antigen CD20; B1; Bp35; MS4A2; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16

Gene ID
931

UniProt ID
P11836

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Biosimilar Overview

Please refer to Ocaratuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ocaratuzumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-771.pdf

MSDS

MSDS - AFC-TAB-771.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Ocaratuzumab"

DrugMonitor™ Anti-Ocaratuzumab Antibody (VS-1224-YC829)
Ocaratuzumab, a humanized monoclonal antibody directed against CD20, is being explored for its efficacy in cancers and autoimmune disorders. The DrugMonitor™ Anti-Ocaratuzumab Antibody (VS-1224-YC829) is an anti-drug antibody (ADA) against Ocaratuzumab. This drug-based antibody is raised in mice immunized with the Ocaratuzumab. The anti-Ocaratuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Ocaratuzumab in samples.

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HPAB-M0706-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0706-YC)	ELISA	Camelid VHH
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CAT	Product Name	Application	Type
PABW-019	Human Anti-MS4A1 Recombinant Antibody (clone C2H7)	WB, IF, FuncS	Chimeric (mouse/human) IgG
FAMAB-0144-CN	Human Anti-MS4A1 Recombinant Antibody (clone C2B8)	WB, ELISA	Chimeric (mouse/human) IgG1
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CAT	Product Name	Application	Type
TAB-1635CL	Anti-Human MS4A1 Recombinant Antibody (BVX20)	Inhib	Humanized antibody
TAB-1636CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1636CL)	ADCC, CDC	Humanized IgG
TAB-1637CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1637CL)	ADCC, CDC	Humanized IgG
TAB-1638CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1638CL)	ADCC, CDC	Humanized IgG
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CAT	Product Name	Application	Type
TAB-1645CL	Anti-Human MS4A1 Recombinant Antibody (2.1.2)	Cyt, FuncS	Fully human antibody
TAB-1646CL	Anti-Human MS4A1 Recombinant Antibody (1.1.2)	Cyt, FuncS	Fully human antibody
TAB-1647CL	Anti-Human MS4A1 Recombinant Antibody (1.5.3)	Cyt, FuncS	Fully human antibody
TAB-1648CL	Anti-MS4A1 Recombinant Antibody (MEDI-552)	Inhib
TAB-1654CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1654CL)	FC, Apop	Human IgG1, κ

CAT	Product Name	Application	Type
TAB-1632CL-S(P)	Anti-Human MS4A1 Recombinant Antibody scFv Fragment (1F5)	FC
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TAB-1633CL-S(P)	Anti-Human MS4A1 Recombinant Antibody scFv Fragment (ch1F5)	FC	Chimeric antibody (mouse/human)
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TAB-1665CL-S(P)	Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1665CL-S(P))	CDC	Mouse scFv
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Gly-059LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Chimeric antibody (mouse/human)
Gly-063LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)
Gly-097LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Chimeric antibody (mouse/human)
Gly-115LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Humanized antibody
Gly-138LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-063LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)
Gly-134LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-135LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-136LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-158LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
Gly-142LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-155LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-171LC	Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application
MHC-LC066	PE-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
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MHC-LC068	BV421-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
MHC-LC4347	PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer	FCM

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
MOR-2295	Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB)	IHC-Fr, IHC-P	Rabbit IgG
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CAT	Product Name	Application	Type
FAMAB-0144-CN-F(E)	Human Anti-MS4A1 Recombinant Antibody (clone C2B8); Fab Fragment	WB, ELISA	Chimeric (mouse/human) Fab
HPAB-0138-WJ-F(E)	Human Anti-MS4A1 Recombinant Antibody (clone L4H7); Fab Fragment	ELISA	Humanized Fab
HPAB-0139-WJ-F(E)	Human Anti-MS4A1 Recombinant Antibody (clone L4H5); Fab Fragment	ELISA	Humanized Fab
HPAB-1321-FY-S(P)	Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-1321-FY-S(P))	FC, ELISA	Human scFv
HPAB-1322-FY-S(P)	Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-1322-FY-S(P))	FC, ELISA	Human scFv

CAT	Product Name	Application	Type
HPAB-0018-FY-S(P)	Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-0018-FY-S(P))	FC	Humanized scFv
HPAB-0021-FY-S(P)	Human Anti-MS4A1 Recombinant Antibody scFv Fragment (HPAB-0021-FY-S(P))	FC	Humanized scFv
HPAB-M0452-YC-S(P)	Canine Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-M0452-YC-S(P))	FC, IHC	Canine scFv
HPAB-M0453-YC-S(P)	Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-M0453-YC-S(P))	FC, IHC	Humanized scFv
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AFC-TAB-772	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-772)	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody
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AFC-TAB-028	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-028)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody
AFC-TAB-207	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-207)	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody
AFC-TAB-H39	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H39)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0424-XY188	AbPlus™ Anti-MS4A1 Magnetic Beads (VS-0424-XY188)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0924-YC138	Human Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC138), CDC Enhanced	FC, CDC, IP	Antibody hexamer
VS-0924-YC139	Mouse Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC139), CDC Enhanced	FC, Activ, Agonist, IF, WB, Cyt, CDC	Antibody hexamer

CAT	Product Name	Application	Type
VS-1024-XY85	Mouse Anti-NHP MS4A1 Recombinant Antibody (VS-1024-XY85)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0125-FY30	Human Anti-MS4A1 (clone RW005) scFv-Fc Chimera	FuncS	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY168	CytoStream™ Rat Anti-MS4A1 Recombinant Antibody (clone GOT214A)	FC	Rat IgG2a, kappa

CAT	Product Name	Application	Type
VS-0425-YC513	Recombinant Anti-MS4A1 Vesicular Antibody, EV Displayed (VS-0425-YC513)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY4510	Anti-MS4A1 Immunohistochemistry Kit	IHC
VS-0525-XY4511	Anti-Mouse MS4A1 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC129	Recombinant Anti-MS4A1 (Bin I x Bin II) Biparatopic Antibody, Tandem scFv	ELISA, FC	Tandem scFv
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