Anti-Human CD20 Recombinant Antibody (Ibritumomab) (CAT#: TAB-001)
Recombinant monoclonal antibody to Human CD20. Ibritumomab tiuxetan, sold under the trade name Zevalin, is a monoclonal antibody radioimmunotherapy treatment for relapsed or refractory, low grade or transformed B cell non-Hodgkin's lymphoma, a lymphoproliferative disorder and thus affects the lymphatic system. The drug uses the monoclonal mouse IgG1 antibody ibritumomab (pronounced as < ih bri TYOO mo mab >) in conjunction with the chelator tiuxetan, to which a radioactive isotope (either yttrium-90 or indium-111) is added. Tiuxetan is a modified version of DTPA whose carbon backbone contains an isothiocyanatobenzyl and a methyl group
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FuncS
Figure 1 Mean ANC, hemoglobin (Hb) concentration, and platelet count (PLT).
Hemoglobin declined 4% to 5% between weeks 5 and 9 after RIT, and ANC decreased 17% to 24% between weeks 5 and 8 after RIT. Mean platelet count declined from 2.5 × 10⁶/L at baseline to less than 0.8 × 10⁶/L at weeks 4 to 5 after RIT. Complete differential blood and platelet counts were obtained before 90Y-ibritumomab administration and weekly thereafter for 12 weeks.
Morschhauser, F., Illidge, T., Huglo, D., Martinelli, G., Paganelli, G., Zinzani, P. L.,... & Stein, H. (2007). Efficacy and safety of yttrium-90 ibritumomab tiuxetan in patients with relapsed or refractory diffuse large B-cell lymphoma not appropriate for autologous stem-cell transplantation. Blood, 110(1), 54-58.
Specifications
- Immunogen
- Human lymphoblastoid cell line SB
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen
- Species Reactivity
- Human
- Applications
- ELISA, IP, FC, FuncS, IF, Neut
- Trade name
- zevalin
- CAS
- 174722-31-7
- Generic Name
- Ibritumomab
- ATC Code
- V10XX02 (90Y)
- DrugBank
- DB00078
- UNII
- 4Q52C550XK
- ChEMBL
- CHEMBL1201606
Product Property
- Purity
- Purity>95% by SDS-PAGE.
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Applications
- Application Notes
- The MS4A1 antibody has been reported in applications of ELISA, IP, FC, FuncS, IF, Neut.
Target
- Alternative Names
- Ibritumomab;zevalin;174722-31-7;Zevalin;Ibritumomab ;DB00078MS4A1;membrane-spanning 4-domains, subfamily A, member 1;CD20;B-lymphocyte antigen CD20;B1;Bp35;MS4A2;CD20 antigen;CD20 receptor;leukocyte surface antigen Leu-16;B-lymphocyte cell-surface antigen
- Gene ID
- 931
- UniProt ID
- P11836
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Ibritumomab"
Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H39)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Mouse antibody to Human MS4A1.
See other products for "MS4A1"
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-016 | Anti-Human CD20 Recombinant Antibody (Rituximab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-207 | Anti-Human CD20 Recombinant Antibody | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
| TAB-1692CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (Zytux) | ELISA, WB | Chimeric antibody (mouse/human) |
| TAB-1700CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (R92-3-1) | ADCC | Chimeric antibody (mouse/human) |
| PABX-026 | Recombinant Human Anti-CD20 Antibody (C2H7) | FuncS | IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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