Recombinant monoclonal antibody to Human CD20. Ibritumomab tiuxetan, sold under the trade name Zevalin, is a monoclonal antibody radioimmunotherapy treatment for relapsed or refractory, low grade or transformed B cell non-Hodgkin's lymphoma, a lymphoproliferative disorder and thus affects the lymphatic system. The drug uses the monoclonal mouse IgG1 antibody ibritumomab (pronounced as < ih bri TYOO mo mab >) in conjunction with the chelator tiuxetan, to which a radioactive isotope (either yttrium-90 or indium-111) is added. Tiuxetan is a modified version of DTPA whose carbon backbone contains an isothiocyanatobenzyl and a methyl group
Figure 1 Mean ANC, hemoglobin (Hb) concentration, and platelet count (PLT).
Hemoglobin declined 4% to 5% between weeks 5 and 9 after RIT, and ANC decreased 17% to 24% between weeks 5 and 8 after RIT. Mean platelet count declined from 2.5 × 10⁶/L at baseline to less than 0.8 × 10⁶/L at weeks 4 to 5 after RIT. Complete differential blood and platelet counts were obtained before 90Y-ibritumomab administration and weekly thereafter for 12 weeks.
Morschhauser, F., Illidge, T., Huglo, D., Martinelli, G., Paganelli, G., Zinzani, P. L.,... & Stein, H. (2007). Efficacy and safety of yttrium-90 ibritumomab tiuxetan in patients with relapsed or refractory diffuse large B-cell lymphoma not appropriate for autologous stem-cell transplantation. Blood, 110(1), 54-58.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ibritumomab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Mouse antibody to Human MS4A1.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-016 | Anti-Human CD20 Recombinant Antibody (Rituximab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
TAB-1633CL | Anti-Human MS4A1 Recombinant Antibody (ch1F5) | FC, Apop, CDC, ADCC, Inhib | Chimeric antibody (mouse/human) |
TAB-1633CL-S(P) | Anti-Human MS4A1 Recombinant Antibody scFv Fragment (ch1F5) | FC | Chimeric antibody (mouse/human) |
TAB-1634CL-S(P) | Anti-Human MS4A1 Recombinant Antibody scFv Fragment (ch1F5-DXL) | FC, Apop, CDC, ADCC, Inhib | Chimeric antibody (mouse/human) |
TAB-1656CL-S(P) | Anti-Human MS4A1 Recombinant Antibody scFv Fragment (ch2B8) | FC, CMCD, ADCC, Activ, Inhib, Depletion | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBZ-143 | Mouse Anti-MS4A1 Recombinant Antibody (clone KM3575); scFv Fragment | WB | Mouse scFv |
HPAB-0819-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone 1F5RKF12); Fab Fragment | ELISA, FC | Humanized Fab |
HPAB-0820-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone RHAxRKF12); Fab Fragment | ELISA, FC | Humanized Fab |
HPAB-0465LY-F(E) | Mouse Anti-MS4A1 Recombinant Antibody (clone CBL004LY); Fab Fragment | ELISA | Mouse Fab |
HPAB-0466LY-F(E) | Mouse Anti-MS4A1 Recombinant Antibody (clone CBL005LY); Fab Fragment | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0001CL | Human Anti-MS4A1 Recombinant Antibody (TAB-0001CL) | ELISA, ADCC, CDC | Human IgG |
TAB-1703CL-S(P) | Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1703CL-S(P)) | FC, CDC, IP | Human scFv |
TAB-1704CL-S(P) | Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1704CL-S(P)) | IP | Human scFv |
TAB-1693CL-F(E) | Anti-MS4A1 Recombinant Antibody Fab Fragment | ELISA | |
PABX-028 | Recombinant Human Anti-CD20 Antibody (Ofatumumab) | WB, ELISA, IF, FuncS, Apop, BA | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1635CL | Anti-Human MS4A1 Recombinant Antibody (BVX20) | Inhib | Humanized antibody |
TAB-1636CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1636CL) | ADCC, CDC | Humanized IgG |
TAB-1637CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1637CL) | ADCC, CDC | Humanized IgG |
TAB-1638CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1638CL) | ADCC, CDC | Humanized IgG |
TAB-1639CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1639CL) | ADCC, CDC, Apop | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1657CL | Anti-Human MS4A1 Recombinant Antibody (1K1422) | Apop, FuncS | |
TAB-1701CL | Mouse Anti-MS4A1 Recombinant Antibody (TAB-1701CL) | FuncS | Mouse IgG |
TAB-1632CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1F5) | FC | |
TAB-1657CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1K1422) | Apop, FuncS | |
TAB-1658CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1K1791) | Apop, FuncS |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-115LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
Gly-134LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-135LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-136LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-137LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-134LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-135LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-136LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-137LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-138LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-142LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-155LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-171LC | Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC066 | PE-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
MHC-LC067 | APC-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
MHC-LC068 | BV421-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
MHC-LC4347 | PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1751CQ | Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) | Neut, FuncS | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2295 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB) | IHC-Fr, IHC-P | Rabbit IgG |
MOR-4024 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS) | FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-027CQ | Human Anti-MS4A1 Recombinant Antibody (clone CBLS-185) | Neut, FuncS | Human IgG1, κ |
FAMAB-0241CQ | Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7) | ELISA, FC, IHC, IP | Mouse IgG2b, κ |
HPAB-0742-CN | Human Anti-MS4A1 Recombinant Antibody (HPAB-0742-CN) | ELISA, FC | Human IgG |
HPAB-0743-CN | Human Anti-MS4A1 Recombinant Antibody (HPAB-0743-CN) | ELISA, FC | Human IgG |
HPAB-0744-CN | Human Anti-MS4A1 Recombinant Antibody (HPAB-0744-CN) | ELISA, FC | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0704-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD25) | ELISA, FuncS | Camelid VHH |
HPAB-M0705-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD16) | ELISA | Camelid VHH |
HPAB-M0706-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone R3CD7) | ELISA | Camelid VHH |
HPAB-M0707-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD78) | ELISA | Camelid VHH |
HPAB-M0708-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD17) | ELISA | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-772 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocrelizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
AFC-TAB-016 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Rituximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-028 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ofatumumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-207 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ublituximab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
AFC-TAB-771 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocaratuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1586-FY-F(E) | Mouse Anti-MS4A1 Recombinant Antibody (clone CD20-7); scFv Fragment | ELISA, Cyt | Mouse scFv |
HPAB-1587-FY-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone huCD20-7); scFv Fragment | ELISA, Cyt | Humanized scFv |
HPAB-1588-FY-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone 3c5); scFv Fragment | ELISA | Human scFv |
HPAB-J0043-YC-S(P) | Mouse Anti-MS4A1 Recombinant Antibody (clone 13.6E12); scFv Fragment | ELISA, FC, FuncS | Mouse scFv |
HPAB-0528-YJ-S(P) | Mouse Anti-MS4A1 Recombinant Antibody (clone 2F4); scFv Fragment | ELISA, IHC | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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