Human Anti-MS4A1 Recombinant Antibody (clone 2F2) (CAT#: PABL-422)
Recombinant Human Antibody (2F2) is capable of binding to CD20, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-CD20 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-CD20 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody is a fully human anti-CD20 antibody that is currently in phase III clinical trial for several types of malignancies and autoimmune diseases and is one of the most promising antiCD20 drugs.
Specific Inquiry
Figure 1 Western blot analysis of purified anti-CD20 mAbs separated by SDS-PAGE.
Lane1, molecular weight protein markers; lane2, C2B8; lane3, 2F2; lane4, C2B8(ScFvHL)4-Fc; lane5, 2F2(ScFvHL)4-Fc.
Li, B., Shi, S., Qian, W., Zhao, L., Zhang, D., Hou, S., ... & Guo, Y. (2008). Development of novel tetravalent anti-CD20 antibodies with potent antitumor activity. Cancer research, 68(7), 2400-2408.
Specifications
- Immunogen
- Human membrane-spanning 4-domains, subfamily A, member 1
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG1,κ
- Specificity
- CD20
- Species Reactivity
- Human
- Clone
- 2F2
- Applications
- WB, ELISA, FuncS
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1;
- Gene ID
- 931
- UniProt ID
- P11836
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-913-sdAb | Recombinant Anti-human MS4A1 VHH Single Domain Antibody | IP, FC, ChiP, Neut | Llama VHH |
| HPAB-M0704-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD25) | ELISA, FuncS | Camelid VHH |
| HPAB-M0705-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD16) | ELISA | Camelid VHH |
| HPAB-M0706-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone R3CD7) | ELISA | Camelid VHH |
| HPAB-M0707-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD78) | ELISA | Camelid VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-772 | Human Anti-MS4A1 Recombinant Antibody (TAB-772) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 |
| TAB-771 | Humanized Anti-MS4A1 Recombinant Antibody (TAB-771) | IF, IP, Neut, FuncS, ELISA, FC, ICC | Humanized IgG1, κ |
| TAB-133 | Anti-Human CD20 Recombinant Antibody (Afutuzumab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG3 - kappa |
| TAB-1635CL | Anti-Human MS4A1 Recombinant Antibody (BVX20) | Inhib | Humanized antibody |
| TAB-1636CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1636CL) | ADCC, CDC | Humanized IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-019 | Human Anti-MS4A1 Recombinant Antibody (clone C2H7) | WB, IF, FuncS | Chimeric (mouse/human) IgG |
| MOB-0279MZ | Mouse Anti-MS4A1 Recombinant Antibody (clone M27 (1, 4).) | IHC | Mouse IgG2a |
| FAMAB-0144-CN | Human Anti-MS4A1 Recombinant Antibody (clone C2B8) | WB, ELISA | Chimeric (mouse/human) IgG1 |
| HPAB-1896LY | Mouse Anti-MS4A1 Recombinant Antibody (clone muCD37-3) | ELISA, Inhib | Mouse IgG |
| HPAB-1897LY | Human Anti-MS4A1 Recombinant Antibody (clone chCD37-3) | ELISA, Inhib | Chimeric (mouse/human) IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-419 | Human Anti-MS4A1 Recombinant Antibody (clone 2F2); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| PFBL-420 | Mouse Anti-MS4A1 Recombinant Antibody (clone GA101); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| HPAB-0683-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone Rmut8); Fab Fragment | ELISA, FC | Chimeric (mouse/human) Fab |
| HPAB-0684-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone Rmut5); Fab Fragment | ELISA, FC | Chimeric (mouse/human) Fab |
| HPAB-0742-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0742-CN-F(E)) | ELISA, FC | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1632CL-S(P) | Anti-Human MS4A1 Recombinant Antibody scFv Fragment (1F5) | FC | |
| TAB-1659CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1K0924) | Apop, FuncS | |
| TAB-1701CL-F(E) | Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1701CL-F(E)) | FuncS | Mouse Fab |
| PABX-026-S (P) | Recombinant Mouse Anti-CD20 Antibody scFv Fragment (C2H7) | WB, ELISA, FuncS | scFv |
| PABX-028-S (P) | Recombinant Human Anti-CD20 Antibody scFv Fragment (Ofatumumab) | WB, ELISA, IF, FuncS | scFv |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1665CL-S(P) | Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1665CL-S(P)) | CDC | Mouse scFv |
| TAB-1666CL-S(P) | Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1666CL-S(P)) | CDC | Mouse scFv |
| TAB-1667CL-S(P) | Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1667CL-S(P)) | CDC | Mouse scFv |
| TAB-1668CL-S(P) | Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1668CL-S(P)) | CDC | Mouse scFv |
| TAB-1669CL-S(P) | Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1669CL-S(P)) | CDC | Mouse scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1654CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1654CL-F(E)) | FC, Apop | Human Fab |
| TAB-1655CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1655CL-F(E)) | ELISA | Human Fab |
| TAB-1674CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (101) | Cyt, ELISA, FuncS, Inhib | |
| TAB-1676CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1676CL-F(E)) | ELISA | Human Fab |
| PABX-028-F (E) | Recombinant Human Anti-CD20 Antibody Fab Fragment (Ofatumumab) | WB, ELISA, IF, FuncS | Fab |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-115LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-134LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-135LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-136LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-137LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Low- or Non-fucosylated Oligosaccharide
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-134LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-135LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-136LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-137LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-138LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Hyper-galactosylated
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-142LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA | Human antibody |
High-mannose Glycoform
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-155LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Humanized antibody |
Deglycosylated Antibody (Non-glycosylated IgGs)
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-171LC | Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) | ELISA | Chimeric antibody (mouse/human) |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC066 | PE-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC067 | APC-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC068 | BV421-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC4347 | PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer | FCM |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1751CQ | Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) | Neut, FuncS | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2295 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB) | IHC-Fr, IHC-P | Rabbit IgG |
| MOR-4024 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS) | FC | Rabbit IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-772 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocrelizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-016 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Rituximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-028 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ofatumumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-207 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ublituximab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-771 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocaratuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1775-FY-F(E) | Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1775-FY-F(E)) | ELISA, Activ | Mouse Fab |
| HPAB-1776-FY-F(E) | Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1776-FY-F(E)) | ELISA, Activ | Mouse Fab |
| HPAB-1777-FY-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone 1.3.3); scFv Fragment | ELISA, Cyt | Human scFv |
| HPAB-1778-FY-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone 1.13.2); scFv Fragment | ELISA, Cyt | Human scFv |
| HPAB-1954-FY-S(P) | Human Anti-MS4A1 Recombinant Antibody (clone BD31-7); scFv Fragment | Cyt | Humanized scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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