Recombinant Chimeric (Human/Mouse) Antibody (C2H7) is capable of binding to CD20. Chimeric 2H7 (C2H7) can mediate complement dependent cytotoxicity and antibody-dependent cellular cytotoxicity effects on CD20 positive human Burkitt lymphoma cells.
Figure 1 Cytotoxicity assays of C2H7 () and Rituximab () on Raji cells.
(A) CDC assays with 10% normal human serum as a source of complement or (B) ADCC assays with human peripheral blood mononuclear cells as effectors were performed with respective antibodies on Raji cells and the activities were determined by measuring the amount of released LDH with the CytoTox 96 non-Radioactive Cytotoxicity Assay kit. All experiments were performed in triplicate and the data are presented as mean ± S.D. (n = 3).
Du, J., Wang, H., Zhong, C., Peng, B., Zhang, M., Li, B., ... & Ding, J. (2008). Crystal structure of chimeric antibody C2H7 Fab in complex with a CD20 peptide. Molecular immunology, 45(10), 2861-2868.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-913-sdAb | Recombinant Anti-human MS4A1 VHH Single Domain Antibody | IP, FC, ChiP, Neut | Llama VHH |
HPAB-M0704-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD25) | ELISA, FuncS | Camelid VHH |
HPAB-M0705-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD16) | ELISA | Camelid VHH |
HPAB-M0706-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone R3CD7) | ELISA | Camelid VHH |
HPAB-M0707-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD78) | ELISA | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1638CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1638CL) | ADCC, CDC | Humanized IgG |
TAB-1639CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1639CL) | ADCC, CDC, Apop | Humanized IgG |
TAB-1640CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1640CL) | ADCC, CDC, Apop, FuncS | Humanized IgG |
TAB-1641CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1641CL) | ADCC, CDC, Apop | Humanized IgG |
TAB-1642CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1642CL) | ADCC, CDC | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1693CL | Anti-MS4A1 Recombinant Antibody | ELISA | |
TAB-1674CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (101) | Cyt, ELISA, FuncS, Inhib | |
TAB-1676CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1676CL-F(E)) | ELISA | Human Fab |
PABX-028 | Recombinant Human Anti-CD20 Antibody (Ofatumumab) | WB, ELISA, IF, FuncS, Apop, BA | IgG |
PABX-028-F (E) | Recombinant Human Anti-CD20 Antibody Fab Fragment (Ofatumumab) | WB, ELISA, IF, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1632CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1F5) | FC | |
TAB-1657CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1K1422) | Apop, FuncS | |
PABX-026-S (P) | Recombinant Mouse Anti-CD20 Antibody scFv Fragment (C2H7) | WB, ELISA, FuncS | scFv |
PABX-028-S (P) | Recombinant Human Anti-CD20 Antibody scFv Fragment (Ofatumumab) | WB, ELISA, IF, FuncS | scFv |
TAB-007ML | Anti-Canine MS4A1 Recombinant Antibody (Blontuvetmab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ, λ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1665CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1665CL-F(E)) | CDC | Chimeric (mouse/human) Fab |
TAB-1666CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1666CL-F(E)) | CDC | Chimeric (mouse/human) Fab |
TAB-1667CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1667CL-F(E)) | CDC | Chimeric (mouse/human) Fab |
TAB-1668CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1668CL-F(E)) | CDC | Chimeric (mouse/human) Fab |
TAB-1669CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1669CL-F(E)) | CDC | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-067LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA, FC | Chimeric antibody (mouse/human) |
Gly-097LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
Gly-154LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
Gly-155LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated | ELISA | Humanized antibody |
Gly-158LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-134LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-135LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-136LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-137LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-138LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-142LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-155LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-171LC | Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0279MZ | Mouse Anti-MS4A1 Recombinant Antibody (clone M27 (1, 4).) | IHC | Mouse IgG2a |
HPAB-0819-CN | Human Anti-MS4A1 Recombinant Antibody (clone 1F5RKF12) | ELISA, FC | Humanized IgG |
HPAB-0820-CN | Human Anti-MS4A1 Recombinant Antibody (clone RHAxRKF12) | ELISA, FC | Humanized IgG |
HPAB-M0452-YC | Canine Anti-MS4A1 Recombinant Antibody (HPAB-M0452-YC) | FC, IHC | Chimeric (human/canine) IgG1 |
HPAB-M0453-YC | Human Anti-MS4A1 Recombinant Antibody (HPAB-M0453-YC) | FC, IHC | Humanized IgGc |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC066 | PE-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
MHC-LC067 | APC-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
MHC-LC068 | BV421-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
MHC-LC4347 | PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1751CQ | Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) | Neut, FuncS | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2295 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB) | IHC-Fr, IHC-P | Rabbit IgG |
MOR-4024 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS) | FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0241CQ-F(E) | Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7); Fab Fragment | ELISA, FC, IHC, IP | Mouse Fab |
HPAB-0683-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone Rmut8); Fab Fragment | ELISA, FC | Chimeric (mouse/human) Fab |
HPAB-0684-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone Rmut5); Fab Fragment | ELISA, FC | Chimeric (mouse/human) Fab |
HPAB-0742-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0742-CN-F(E)) | ELISA, FC | Human Fab |
HPAB-0743-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0743-CN-F(E)) | ELISA, FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-772 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocrelizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
AFC-TAB-016 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Rituximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-028 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ofatumumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-207 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ublituximab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
AFC-TAB-771 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocaratuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-J0043-YC-S(P) | Mouse Anti-MS4A1 Recombinant Antibody (clone 13.6E12); scFv Fragment | ELISA, FC, FuncS | Mouse scFv |
HPAB-0528-YJ-S(P) | Mouse Anti-MS4A1 Recombinant Antibody (clone 2F4); scFv Fragment | ELISA, IHC | Mouse scFv |
HPAB-0529-YJ-S(P) | Mouse Anti-MS4A1 Recombinant Antibody (clone ch2F4); scFv Fragment | ELISA, IHC | Mouse scFv |
HPAB-1885-FY-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1885-FY-F(E)) | ELISA, FC | Human Fab |
HPAB-1954-FY-S(P) | Human Anti-MS4A1 Recombinant Antibody (clone BD31-7); scFv Fragment | Cyt | Humanized scFv |
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