Human Anti-MS4A1 (clone RW005) scFv-Fc Chimera
CAT#: VS-0125-FY30
The anti-CD20 scFv-Fc is a specialized monoclonal antibody designed to selectively bind to CD20, an antigen predominantly found on the surface of B cells. By targeting these CD20-positive cells, the antibody effectively mediates their destruction, which holds significant implications for the treatment of various B cell-related malignancies, including lymphoma and leukemia. Given its targeted mechanism of action, the anti-CD20 scFv-Fc represents a promising therapeutic option, potentially improving outcomes for patients suffering from these challenging diseases.
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Antibody Isotype
- scFv-Fc
- Species Reactivity
- Human
- Clone
- RW005
- Applications
- Functional Assay
- Related Disease
- For treating B cell-related diseases such as lymphoma and leukemia
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- CD20, as an antigen primarily expressed on the surface of B cells, is significant for providing potential research directions for the treatment of B cell-related diseases such as lymphoma and leukemia. Research can focus on the mechanisms, efficacy, and optimization of CD20 antibodies, as well as their role in different pathological states of B cells, with the aim of developing more effective treatment strategies.
Target
- Alternative Names
- Membrane Spanning 4-Domains A1; Membrane-Spanning 4-Domains, Subfamily A, Member 1; Leukocyte Surface Antigen Leu-16; CD20 Antigen; CD20; Bp35; Membrane-Spanning 4-Domains Subfamily A Member 1; B-Lymphocyte Cell-Surface Antigen B1; B-Lymphocyte Surface Antigen B1
- Gene ID
- 931
- UniProt ID
- P11836
- Sequence Similarities
- Belongs to the MS4A family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate.
- Protein Refseq
- NP_068769.2; NP_690605.1
- Function
- B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes.
Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "Clone RW005"
- CAT
- Product Name
See other products for "MS4A1"
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| TAB-H27 | Anti-Human MS4A1 Recombinant Antibody (Epitumomab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG2a |
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| TAB-133 | Anti-Human CD20 Recombinant Antibody (Afutuzumab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG3 - kappa |
| CAT | Product Name | Application | Type |
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| TAB-H39 | Anti-Human MS4A1 Recombinant Antibody (Ibritumomab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | Mouse IgG1 - kappa |
| CAT | Product Name | Application | Type |
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| TAB-537CL | Human Anti-MS4A1 Recombinant Antibody (TAB-537CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
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| PABZ-143 | Human Anti-MS4A1 Recombinant Antibody (clone KM3575) | WB | Chimeric (mouse/human) IgG1, κ |
| CAT | Product Name | Application | Type |
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| PABL-422 | Human Anti-MS4A1 Recombinant Antibody (clone 2F2) | WB, ELISA, FuncS | Human IgG1,κ |
| CAT | Product Name | Application | Type |
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| PABL-423 | Mouse Anti-MS4A1 Recombinant Antibody (clone GA101) | FC, Activ, Agonist, IF, WB, Cyt, FuncS | Mouse IgG |
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| PFBW-019 | Human Anti-MS4A1 Recombinant Antibody (clone C2H7); Fab Fragment | WB, IF, FuncS | Chimeric (mouse/human) IgG |
| CAT | Product Name | Application | Type |
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| PFBZ-143 | Human Anti-MS4A1 Recombinant Antibody (clone KM3575); Fab Fragment | WB | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
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| PFBL-419 | Human Anti-MS4A1 Recombinant Antibody (clone 2F2); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-420 | Mouse Anti-MS4A1 Recombinant Antibody (clone GA101); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-019 | Mouse Anti-MS4A1 Recombinant Antibody (clone C2H7); scFv Fragment | WB, IF, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-143 | Mouse Anti-MS4A1 Recombinant Antibody (clone KM3575); scFv Fragment | WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-419 | Human Anti-MS4A1 Recombinant Antibody (clone 2F2); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-420 | Mouse Anti-MS4A1 Recombinant Antibody (clone GA101); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0001CL | Human Anti-MS4A1 Recombinant Antibody (TAB-0001CL) | ELISA, ADCC, CDC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1633CL | Anti-Human MS4A1 Recombinant Antibody (ch1F5) | FC, Apop, CDC, ADCC, Inhib | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1634CL | Anti-Human MS4A1 Recombinant Antibody (ch1F5-DXL) | FC, Apop, CDC, ADCC, Inhib | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1645CL | Anti-Human MS4A1 Recombinant Antibody (2.1.2) | Cyt, FuncS | Fully human antibody |
| CAT | Product Name | Application | Type |
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| TAB-1646CL | Anti-Human MS4A1 Recombinant Antibody (1.1.2) | Cyt, FuncS | Fully human antibody |
| CAT | Product Name | Application | Type |
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| TAB-1647CL | Anti-Human MS4A1 Recombinant Antibody (1.5.3) | Cyt, FuncS | Fully human antibody |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| Gly-059LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| Gly-097LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| Gly-115LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-063LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (mouse/human) |
| Gly-063LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (mouse/human) |
| Gly-134LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-135LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-136LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-137LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-138LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-142LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-155LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-171LC | Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
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| MOB-0279MZ | Mouse Anti-MS4A1 Recombinant Antibody (clone M27 (1, 4).) | IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
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| MHC-LC066 | PE-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC067 | APC-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC068 | BV421-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
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| NEUT-1751CQ | Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) | Neut, FuncS | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2295 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB) | IHC-Fr, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4024 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC4347 | PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0241CQ-F(E) | Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7); Fab Fragment | ELISA, FC, IHC, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0241CQ-S(P) | Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7); scFv Fragment | ELISA, FC, IHC, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
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| HPAB-M0704-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0704-YC) | ELISA, FuncS | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0705-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0705-YC) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0706-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0706-YC) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0707-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0707-YC) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-772 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-772) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-016 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-016) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-028 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-028) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-207 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-207) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
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| AFC-TAB-771 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-771) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY188 | AbPlus™ Anti-MS4A1 Magnetic Beads (VS-0424-XY188) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC138 | Human Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC138), CDC Enhanced | FC, CDC, IP | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC139 | Mouse Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC139), CDC Enhanced | FC, Activ, Agonist, IF, WB, Cyt, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY85 | Mouse Anti-NHP MS4A1 Recombinant Antibody (VS-1024-XY85) | FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY168 | CytoStream™ Rat Anti-MS4A1 Recombinant Antibody (clone GOT214A) | FC | Rat IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC513 | Recombinant Anti-MS4A1 Vesicular Antibody, EV Displayed (VS-0425-YC513) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4510 | Anti-MS4A1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4511 | Anti-Mouse MS4A1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC129 | Recombinant Anti-MS4A1 (Bin I x Bin II) Biparatopic Antibody, Tandem scFv | ELISA, FC | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC222 | Recombinant Anti-MS4A1 Biparatopic Antibody, Tandem scFv | ELISA, IF, WB | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC17 | SmartAb™ Recombinant Anti-MS4A1 pH-dependent Antibody (VS-0825-YC17) | FC, Inhib | Human IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC257 | SmartAb™ Recombinant Anti-MS4A1 pH-dependent Antibody (Clone Rituximab) | IF, IP, Neut, ELISA, FC, WB | Human IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1025-YC1 | Anti-MS4A1 Antibody Prodrug, Protease Activated (Rituximab) | ISZ, Cyt, FuncS |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1025-YC158 | Anti-MS4A1 Antibody Prodrug, Protease Activated (2H7) | ISZ, Cyt, FuncS |
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