Anti-CDH3-sulfo-SMCC-ADC
CAT#: ADC-242CL
This ADC product is composed of an anti-CDH3 antibody conjugated via sulfo-SMCC linker to drug payload (anti-CDH3-sulfo-SMCC).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to plasma membrane & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/1032_G9_1_selected.jpg
Normal Tissue
Figure 2 Skin 1
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_B_8_1_val_selected.jpg
Normal Tissue
Figure 3 Oral mucosa
Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_A_8_1.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_A_8_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Collecting ducts Staining: Medium Intensity: Moderate Quantity:>75% Distal tubules Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1767/8164_A_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (A-431, HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000062038-CDH3
❮
❯
Specifications
- Antibody Overview
- Anti-Human CDH3 Chimeric Antibody
- Linker
- sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late)
- Linker Class/Description
- Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
Target
- Introduction
- This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]
- Alternative Names
- CDH3; cadherin 3, type 1, P-cadherin (placental); CDHP; HJMD; PCAD; cadherin-3; calcium-dependent adhesion protein, placental;
- Gene ID
- 1001
- UniProt ID
- P22223
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ADC-242CL. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CDH3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0943CL | Mouse Anti-CDH3 Recombinant Antibody (TAB-0943CL) | Inhib | Mouse IgG |
| TAB-0943CL-S(P) | Mouse Anti-CDH3 Recombinant Antibody; scFv Fragment (TAB-0943CL-S(P)) | SDS-PAGE | Mouse scFv |
| TAB-0943CL-F(E) | Mouse Anti-CDH3 Recombinant Antibody; Fab Fragment (TAB-0943CL-F(E)) | SDS-PAGE | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0944CL | Human Anti-CDH3 Recombinant Antibody (TAB-0944CL) | ELISA | Human IgG |
| TAB-0944CL-S(P) | Human Anti-CDH3 Recombinant Antibody; scFv Fragment (TAB-0944CL-S(P)) | ELISA | Human scFv |
| TAB-0944CL-F(E) | Human Anti-CDH3 Recombinant Antibody; Fab Fragment (TAB-0944CL-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2230MZ | Recombinant Mouse Anti-Human CDH3 Antibody (clone 67D2) | IHC-P | Mouse antibody |
| PABC-251 | Mouse Anti-CDH3 Recombinant Antibody (clone TSP7) | ELISA, Inhib, Live cell imaging | Mouse IgG |
| PABC-252 | Mouse Anti-CDH3 Recombinant Antibody (clone TSP11) | ELISA, Inhib, Live cell imaging | Mouse IgG |
| PABC-253 | Mouse Anti-CDH3 Recombinant Antibody (clone TSP5) | ELISA, Inhib, Live cell imaging | Mouse IgG |
| HPAB-0390-FY | Human Anti-CDH3 Recombinant Antibody (HPAB-0390-FY) | IHC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-446CQ | Mouse Anti-CDH3 Recombinant Antibody (VMC175) | ICC, IF, WB, IP, Block | Mouse IgG1 |
| NEUT-447CQ | Mouse Anti-CDH3 Recombinant Antibody (clone NCC-CAD-299) | IHC-Fr, Inhib, WB | Mouse IgG1 |
| NEUT-448CQ | Rat Anti-Cdh3 Recombinant Antibody (clone PCD-1) | ELISA, Inhib, IF, WB, IHC-P, IHC-Fr, FC, IV | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0619 | Hi-Affi™ Rabbit Anti-CDH3 Recombinant Antibody (clone DS619AB) | WB, IP, FC, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0142CQ-F(E) | Human Anti-CDH3 Recombinant Antibody (clone 194-b09); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0143CQ-F(E) | Human Anti-CDH3 Recombinant Antibody (clone 194-g09); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-2071LY-F(E) | Human Anti-CDH3 Recombinant Antibody; Fab Fragment (HPAB-2071LY-F(E)) | ELISA | Human Fab |
| HPAB-0400-YJ-F(E) | Human Anti-CDH3 Recombinant Antibody; Fab Fragment (HPAB-0400-YJ-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-0401-YJ-F(E) | Human Anti-CDH3 Recombinant Antibody; Fab Fragment (HPAB-0401-YJ-F(E)) | ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0142CQ-S(P) | Human Anti-CDH3 Recombinant Antibody (clone 194-b09); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0143CQ-S(P) | Human Anti-CDH3 Recombinant Antibody (clone 194-g09); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0144CQ-S(P) | Human Anti-CDH3 Recombinant Antibody (clone 196-g03); scFv Fragment | ELISA, FC | Human scFv |
| PSBC-251 | Mouse Anti-CDH3 Recombinant Antibody (clone TSP7); scFv Fragment | ELISA, Inhib, Live cell imaging | Mouse scFv |
| PSBC-252 | Mouse Anti-CDH3 Recombinant Antibody (clone TSP11); scFv Fragment | ELISA, Inhib, Live cell imaging | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0513 | PE-A*24:02/Human CDH3 (DYLNEWGSRF) MHC Tetramer | FCM, IHC | |
| MHC-CN0514 | APC-A*24:02/Human CDH3 (DYLNEWGSRF) MHC Tetramer | FCM, IHC | |
| MHC-CN0515 | FITC-A*24:02/Human CDH3 (DYLNEWGSRF) MHC Tetramer | FCM, IHC | |
| MHC-CN0516 | A*24:02/Human CDH3 (DYLNEWGSRF) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC427 | Recombinant Anti-CDH3 Vesicular Antibody, EV Displayed (VS-0425-YC427) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1295 | Anti-CDH3 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, IHC, ELISA, FC
Application: ELISA, IHC, FC, IP, IF, BL
Application: ELISA
Application: ELISA, FC, IHC, Neut
-2.png)
Application: ELISA
Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
