Anti-CD63 (clone Hu33-11A) Recombinant Antibody Coupled Liposome (VS-1024-FY88)
CAT#: VS-1024-FY88
Anti-CD63 antibody conjugated liposomes represent a novel targeted therapeutic tool for the research and treatment of glioma. CD63 is a protein that is overexpressed on the surface of glioma cells, which enhances the selectivity and targeting of liposomes. By coupling anti-CD63 antibodies to liposomes, drugs or therapeutic agents can be effectively delivered directly to tumor cells, minimizing damage to normal tissues. This conjugated liposome system can significantly improve the bioavailability and efficacy of the drugs while reducing side effects. The comprehensive application of this technology involving anti-CD63 antibody conjugated liposomes presents a very optimistic outlook for the treatment of gliomas.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73506/1798_B5_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26356/if_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in subsets of bone marrow poietic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10088/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26356/ihc_selected.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10088/26867_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Collecting ducts
Staining:Medium
Intensity: Strong
Quantity: <25%
Distal tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10088/26867_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10088/26867_A_4_6.jpg
Normal Tissue
Figure 8 Bone marrow
Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10088/26880_B_6_4.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (ASC diff)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000135404-CD63
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- Hu33-11A
- Antibody Type
- IgG1, kappa
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that has been specifically engineered to bind with high affinity to the human CD63 protein. CD63 is a tetraspanin protein that is expressed on the surface of various cell types, including immune cells, and plays a crucial role in cellular processes such as adhesion, migration, and activation. The development of this monoclonal antibody involves sophisticated biotechnological methods to ensure its specificity and efficacy.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD63
- Introduction
- The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
- Alternative Names
- CD63 antigen; Granulophysin; LAMP-3; Limp1; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30
- Full Name
- CD63 Molecule
- Gene ID
- 967
- UniProt ID
- P08962
- Sequence Similarities
- Belongs to the tetraspanin (TM4SF) family.
- Cellular Localization
- Cell membrane, Endosome, Lysosome, Membrane, Secreted
- Post Translation Modifications
- Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).
- Protein Refseq
- NP_001244318.1; NP_001244319.1; NP_001244320.1
- Function
- Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
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Datasheet
MSDS
COA
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|---|---|---|---|
| MOB-1956z | Mouse Anti-CD63 Recombinant Antibody (clone 38C9) | WB, ELISA, FC, ICC, IF, IP, Dot, FuncS | Mouse IgG1, κ |
| VS3-CJ528 | Mouse Anti-CD63 Recombinant Antibody (clone H5C6) | IF, FC | Mouse IgG1 |
| VS3-CJ529 | Mouse Anti-CD63 Recombinant Antibody (clone PT1531) | IHC-P | Mouse IgG2a, κ |
| VS3-CJ530 | Mouse Anti-CD63 Recombinant Antibody (clone ABT-CD63) | IHC-P | Mouse IgG2a, κ |
| VS3-CJ531 | Rabbit Anti-CD63 Recombinant Antibody (VS3-CJ531) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0575 | Hi-Affi™ Rabbit Anti-CD63 Recombinant Antibody (clone DS575AB) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0071-YJ-S(P) | Human Anti-CD63 Recombinant Antibody (clone Hu33-11A); scFv Fragment | FC, ELISA, IHC | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0071-YJ-F(E) | Human Anti-CD63 Recombinant Antibody (clone Hu33-11A); Fab Fragment | FC, ELISA, IHC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY64 | CytoStream™ Mouse Anti-CD63 Recombinant Antibody (clone AD1) | FC, IHC, IP | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY369 | Anti-CD63 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1207 | Anti-Mouse CD63 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1208 | Anti-Rat CD63 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC180 | Recombinant Anti-CD63 Vesicular Antibody, EV Displayed (VS-0425-YC180) | ELISA, FC, Inhib, Cell-uptake |
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