Anti-CD63 (clone Hu33-11A) Recombinant Antibody Coupled Liposome (VS-1024-FY88) (CAT#: VS-1024-FY88)

• Potential Clinical Applications
• Glioma

• Clone
• Hu33-11A

• Antibody Type
• IgG1, kappa

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant human monoclonal antibody that has been specifically engineered to bind with high affinity to the human CD63 protein. CD63 is a tetraspanin protein that is expressed on the surface of various cell types, including immune cells, and plays a crucial role in cellular processes such as adhesion, migration, and activation. The development of this monoclonal antibody involves sophisticated biotechnological methods to ensure its specificity and efficacy.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• CD63

• Introduction
• The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.

• Alternative Names
• CD63 antigen; Granulophysin; LAMP-3; Limp1; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30

• Full Name
• CD63 Molecule

• Gene ID
• 967

• UniProt ID
• P08962

• Sequence Similarities
• Belongs to the tetraspanin (TM4SF) family.

• Cellular Localization
• Cell membrane, Endosome, Lysosome, Membrane, Secreted

• Post Translation Modifications
• Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).

• Protein Refseq
• NP_001244318.1; NP_001244319.1; NP_001244320.1

• Function
• Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.

• HPAB-0071-YJ
• Human Anti-CD63 Recombinant Antibody (clone Hu33-11A)

• HPAB-0071-YJ-F(E)
• Human Anti-CD63 Recombinant Antibody (clone Hu33-11A); Fab Fragment

• HPAB-0071-YJ-S(P)
• Human Anti-CD63 Recombinant Antibody (clone Hu33-11A); scFv Fragment

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