Anti-GSN (clone W24V103) Recombinant Antibody Coupled Liposome (VS-1024-FY105)
CAT#: VS-1024-FY105
Liposomes designed to target anti-gelsolin (anti-GSN) antibodies exhibit significant promise in the targeted treatment of gliomas, a type of brain tumor known for its aggressive nature. By specifically homing in on glioma cells, these liposomes can deliver therapeutic agents directly to the tumor site, which not only improves the effectiveness of the treatment but also minimizes the adverse effects typically associated with conventional therapies on healthy surrounding tissues. This innovative approach holds the potential to revolutionize glioma treatment, providing a more precise and individualized therapeutic strategy that enhances patient outcomes while safeguarding normal cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to actin filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16728/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in dendritic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54026/138110_A_5_8_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_8_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_B_7_5.jpg
Normal Tissue
Figure 5 Lung
Alveolar cells type I Staining: Low Intensity: Weak Quantity: 75%-25% Alveolar cells type I I Staining: Low Intensity: Weak Quantity: 75%-25% Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Macrophages Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_2_4.jpg
Normal Tissue
Figure 6 Colon
Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75% Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25% Peripheral nerve/ganglion Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10823/24834_A_8_3.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, HaCaT)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148180-GSN
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V103
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that has been engineered to specifically target and bind to human gelsolin (GSN). Gelsolin is a crucial actin-binding protein that plays a significant role in the regulation of actin dynamics within cells.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- GSN
- Introduction
- The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
- Alternative Names
- Gelsolin; Actin-Depolymerizing Factor; Brevin; AGEL; ADF; Gelsolin (Amyloidosis, Finnish Type); Amyloidosis, Finnish Type
- Full Name
- Gelsolin
- Gene ID
- 2934
- UniProt ID
- P06396
- Cellular Localization
- Amyloid, Cytoplasm, Cytoskeleton, Secreted
- Positive Control
- The positive control samples for this antibody include MCF-7, C6, Hela lysates.
- Post Translation Modifications
- Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.
- Protein Refseq
- XP_005252001.1; XP_011516887.1; XP_011516896.1; XP_016870134.1; XP_047279221.1
- Function
- Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (PubMed:19666512).
Plays a role in ciliogenesis.
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Datasheet
MSDS
COA
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See other products for "GSN"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2035z | Mouse Anti-GSN Recombinant Antibody (clone 33A5) | WB, ELISA, ICC, IF, IHC | Mouse IgG1, κ |
| MOB-2046MZ | Recombinant Mouse Anti-Human GSN Antibody (clone HFM-53) | FC, IHC-Fr, IHC-P, WB | Mouse antibody |
| MRO-0645-CN | Rabbit Anti-GSN Recombinant Antibody (clone JB36-68) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-FY625 | Recombinant Rabbit Anti-GSN Antibody (clone R06-4B4) | WB, IHC-Fr, IHC-P, ICC, IF | Rabbit IgG |
| VS3-FY1726 | Rabbit Anti-GSN Recombinant Antibody (clone R06-2I7) | WB, IHC-P, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-071 | Recombinant Anti-Mouse Gsn VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| PNBL-100 | Recombinant Anti-GSN VHH Single Domain Antibody (PNBL-100) | BL, ELISA, IP, IHC, WB | Llama VHH |
| HPAB-0342CQ | Recombinant Llama Anti-GSN Single Domain Antibody (HPAB-0342CQ) | ELISA, IHC, IF, IP, Pull down, FuncS | Llama VHH |
| HPAB-0343CQ | Recombinant Llama Anti-GSN Single Domain Antibody (HPAB-0343CQ) | ELISA, IHC, IF, IP, Pull down, FuncS | Llama VHH |
| NBD-0041-YJ-VHH | Camelid Anti-GSN Recombinant Single Domain Antibody (NBD-0041-YJ-VHH) | ELISA, IF, Inhib | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1527 | Rabbit Anti-GSN Recombinant Antibody (clone DS1527AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY784 | Mouse Anti-GSN Recombinant Antibody (clone 328CT2.2.1) | WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2946 | Anti-GSN Immunohistochemistry Kit | IHC | |
| VS-0525-XY2947 | Anti-Mouse GSN Immunohistochemistry Kit | IHC | |
| VS-0525-XY2948 | Anti-Bovine GSN Immunohistochemistry Kit | IHC |
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