Human Anti-HIV-1 Env Recombinant Antibody (clone 13.6A) (CAT#: MRO-2789CQ)
Recombinant human antibody to Env. 13.6A can neutralize HIV-1 isolates.
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Neu
Figure 1 Neutralization profile of 205F Envs by autologous monoclonal antibody-containing supernatants from B cell hybridomas 13.6A.
Neutralization activity of 13.6A (B) B cell hybridoma supernatant was evaluated against pseudoviruses expressing autologous 205F Envs.
Rong, R., Li, B., Lynch, R. M., Haaland, R. E., Murphy, M. K., Mulenga, J., ... & Robinson, J. E. (2009). Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathways. PLoS pathogens, 5(9).
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Figure 2 Potential N-linked glycosylation sites in V1 and V2 modulate sensitivity to Mabs.
Neutralization of 0-month EnvPL6.3 and the sitedirected mutants shown in panel B was evaluated for 13.6A using reduction of luciferase production in JC53-BL13 cells.
Rong, R., Li, B., Lynch, R. M., Haaland, R. E., Murphy, M. K., Mulenga, J., ... & Robinson, J. E. (2009). Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathways. PLoS pathogens, 5(9).
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Recognizes HIV-1 Env
- Species Reactivity
- HIV-1
- Clone
- 13.6A
- Applications
- ELISA, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 Env antibody has been reported in applications of Neutralization.
Target
- Alternative Names
- ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160; precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-474-S(P) | Recombinant Anti-HIV-1 Env Antibody scFv Fragment | WB, ELISA, IHC, FuncS | scFv |
| PSBL-379 | Human Anti-HIV-1 Env Recombinant Antibody (clone VRC0); scFv Fragment | Neut, FuncS | Human scFv |
| PSBL-381 | Human Anti-HIV-1 Env Recombinant Antibody (clone VRC07); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| MRO-2786CQ-S(P) | Human Anti-HIV-1 Env Recombinant Antibody scFv Fragment (MRO-2786CQ-S(P)) | ELISA, FC, Neut | Human scFv |
| MRO-2787CQ-S(P) | Human Anti-HIV-1 Env Recombinant Antibody (clone PGT152); scFv Fragment | Neut | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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