Rabbit Anti-HIV-1 gp41 Recombinant Antibody (clone 8K8) (CAT#: MRO-4201CQ)
Recombinant Rabbit Antibody to gp41. The antibody can neutralize HIV-1.
Specific Inquiry
Neut
Figure 1 Presence of 10E8 diminishes neutralization sensitivity of HIV-1.
The maximum infectivity of virus in presence or absence of 10E8 was normalized to 100% for mutant F673L.
Kim, A. S., Leaman, D. P., & Zwick, M. B. (2014). Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization. PLoS pathogens, 10(7).
WB
Figure 2 10E8 binds less efficiently to Env spikes of MPER mutant F673A compared to wild type.
10E8, 4E10 or Z13e1 Fabs were incubated with JR-FL wild type or F673A
virions and resulting changes to gel mobility of Env trimers was determined using BN-PAGE and Western blot.
Kim, A. S., Leaman, D. P., & Zwick, M. B. (2014). Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization. PLoS pathogens, 10(7).
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Recognizes HIV-1 gp41
- Species Reactivity
- HIV-1
- Clone
- 8K8
- Applications
- WB, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 gp41 antibody has been reported in applications of Western Blot, Neutralization.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP41; gp41; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-486-F(E) | Recombinant Anti-HIV-1 gp41 Antibody Fab Fragment | ELISA, FacS, FuncS | Fab |
| MHH-486-F(E) | Recombinant Human Anti-HIV-1 gp41 Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| PFBL-185 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 8062); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| PFBL-186 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 2F5); Fab Fragment | WB, Neut, FuncS | Human Fab |
| PFBL-187 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC176); Fab Fragment | Neut, FuncS | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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