Rabbit Anti-HIV-1 gp41 Recombinant Antibody (clone 8K8) (CAT#: MRO-4201CQ)
Recombinant Rabbit Antibody to gp41. The antibody can neutralize HIV-1.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Neut
Figure 1 Presence of 10E8 diminishes neutralization sensitivity of HIV-1.
The maximum infectivity of virus in presence or absence of 10E8 was normalized to 100% for mutant F673L.
Kim, A. S., Leaman, D. P., & Zwick, M. B. (2014). Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization. PLoS pathogens, 10(7).
WB
Figure 2 10E8 binds less efficiently to Env spikes of MPER mutant F673A compared to wild type.
10E8, 4E10 or Z13e1 Fabs were incubated with JR-FL wild type or F673A
virions and resulting changes to gel mobility of Env trimers was determined using BN-PAGE and Western blot.
Kim, A. S., Leaman, D. P., & Zwick, M. B. (2014). Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization. PLoS pathogens, 10(7).
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Recognizes HIV-1 gp41
- Species Reactivity
- HIV-1
- Clone
- 8K8
- Applications
- WB, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 gp41 antibody has been reported in applications of Western Blot, Neutralization.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP41; gp41; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimeras
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-486 | Recombinant Anti-HIV-1 gp41 Antibody | WB, Dot, FuncS | IgG |
| MRO-849CQ | Human Anti-HIV-1 gp41 Recombinant Antibody (MRO-849CQ) | ELISA | Human IgG1, λ |
| MRO-850CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (MRO-850CQ) | ELISA, IP, IF | Mouse IgG1 |
| MRO-851CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (MRO-851CQ) | ELISA, WB | Mouse IgG1 |
| MRO-852CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 1D4) | ELISA, WB | Mouse IgG1 |
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