Anti-HLA-DRA (clone DN1924) Recombinant Antibody Coupled Liposome (VS-1024-FY183)
CAT#: VS-1024-FY183
HLA-DRA is a molecule involved in immune response, often manipulated in melanoma. Targeting HLA-DRA with specific antibodies conjugated to liposomes may boost the immune response against melanoma cells. This strategy holds promise for enhancing anti-tumor immunity. Clinical studies could validate the efficacy of this approach in melanoma therapy.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_8_3.jpg
Normal Tissue
Figure 3 High expression in lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_7_8.jpg
Normal Tissue
Figure 4 Tonsil
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_5_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, REH, U-266/70, U-698, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204287-HLA-DRA
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- DN1924
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was specifically engineered to target and bind to the human leukocyte antigen class II, HLA-DRA. HLA-DRA is a crucial component of the major histocompatibility complex (MHC) class II molecules, which play a vital role in the immune response by presenting peptide antigens to CD4+ T cells.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- HLA-DRA
- Introduction
- HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
- Alternative Names
- HLA-DRA1
- Full Name
- Major Histocompatibility Complex, Class II, DR Alpha
- Gene ID
- 3122
- UniProt ID
- P01903
- Sequence Similarities
- Belongs to the MHC class II family.
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein; Endoplasmic reticulum membrane; Single-pass type I membrane protein; Early endosome membrane; Single-pass type I membrane protein; Late endosome membrane; Single-pass type I membrane protein; Lysosome membrane; Single-pass type I membrane protein; Autolysosome membrane; Single-pass type I membrane protein
- Post Translation Modifications
- Ubiquitinated by MARCHF1 or MARCHF8 at Lys-244 leading to down-regulation of MHCII.
When associated with ubiquitination of the beta chain at 'Lys-254', the down-regulation of MHCII may be highly effective.
- Protein Refseq
- NP_061984.2
- Function
- An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule.
In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells.
This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0025-YJ-F(E) | Human Anti-HLA-DRA Recombinant Antibody (clone ChDN1924); Fab Fragment | Apop, IF | Chimeric (mouse/human) Fab |
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