Anti-HLA-DRA (clone DN1924) Recombinant Antibody Coupled Liposome (VS-1024-FY183) (CAT#: VS-1024-FY183)

• Potential Clinical Applications
• Melanoma

• Clone
• DN1924

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody that was specifically engineered to target and bind to the human leukocyte antigen class II, HLA-DRA. HLA-DRA is a crucial component of the major histocompatibility complex (MHC) class II molecules, which play a vital role in the immune response by presenting peptide antigens to CD4+ T cells.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• HLA-DRA

• Introduction
• HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.

• Alternative Names
• HLA-DRA1

• Full Name
• Major Histocompatibility Complex, Class II, DR Alpha

• Gene ID
• 3122

• UniProt ID
• P01903

• Sequence Similarities
• Belongs to the MHC class II family.

• Cellular Localization
• Cell membrane; Single-pass type I membrane protein; Endoplasmic reticulum membrane; Single-pass type I membrane protein; Early endosome membrane; Single-pass type I membrane protein; Late endosome membrane; Single-pass type I membrane protein; Lysosome membrane; Single-pass type I membrane protein; Autolysosome membrane; Single-pass type I membrane protein

• Post Translation Modifications
• Ubiquitinated by MARCHF1 or MARCHF8 at Lys-244 leading to down-regulation of MHCII.
  When associated with ubiquitination of the beta chain at 'Lys-254', the down-regulation of MHCII may be highly effective.

• Protein Refseq
• NP_061984.2

• Function
• An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule.
  In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells.
  This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells.

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