Anti-KDR (clone 1121B) Recombinant Antibody Coupled Liposome (VS-1024-FY53) (CAT#: VS-1024-FY53)

• Potential Clinical Applications
• Cancer

• Clone
• 1121B

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This recombinant mouse antibody (1121B) demonstrates the ability to bind to VEGFR2. The anti-VEGF receptor 2 antibody represents a promising antiangiogenic therapeutic agent under investigation for the treatment of breast and gastric cancer.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• KDR

• Introduction
• Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.

• Alternative Names
• Kinase Insert Domain Receptor; Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase); Vascular Endothelial Growth Factor Receptor 2; Protein-Tyrosine Kinase Receptor Flk-1; Fetal Liver Kinase 1; EC 2.7.10.1; VEGFR2; FLK1; Tyrosine Kinase Growth Factor Receptor

• Full Name
• Kinase Insert Domain Receptor

• Gene ID
• 3791

• UniProt ID
• P35968

• Sequence Similarities
• Belongs to the protein kinase superfamily.

• Cellular Localization
• Cell junction; Endoplasmic reticulum; Cell membrane

• Post Translation Modifications
• N-glycosylated. ( P35968-VGFR2_HUMAN )
  Ubiquitinated.

• Protein Refseq
• NP_002244.1

• Function
• Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD.
  Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis.
  Promotes proliferation, survival, migration and differentiation of endothelial cells.
  Promotes reorganization of the actin cytoskeleton.
  Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD.
  Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4.

• VS-0325-FY84
• Human Anti-KDR (clone 1121B) scFv-Fc Chimera

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