Rabbit Anti-LATS1 Polyclonal Antibody
CAT#: VS3-WK1566
This antibody is a rabbit polyclonal antibody against human LATS1, which is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. It was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen (synthesized peptide derived from human LATS1). It can detect endogenous levels of LATS1. This product was tested for use in WB and ELISA.
Specifications
- Immunogen
- Synthesized peptide derived from human LATS1/2
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human LATS1
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Polyclonal
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 0.5% BSA, 50% Glycerol
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:500) and ELISA (1:10000-1/20000).
Target
- Alternative Names
- Large Tumor Suppressor Kinase 1; LATS (Large Tumor Suppressor, Drosophila) Homolog 1; Large Tumor Suppressor Homolog 1; WARTS Protein Kinase; H-Warts; WARTSLATS, Large Tumor Suppressor, Homolog 1 (Drosophila); LATS, Large Tumor Suppressor, Homolog 1; Serine/Threonine-Protein Kinase LATS1; EC 2.7.11.1; Wts
- Gene ID
- 9113
- UniProt ID
- O95835
- Long Name
- Large Tumor Suppressor Kinase 1
- Sequence Similarities
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
- Cellular Localization
- Cytoplasm, Cytoskeleton
- Post Translation Modifications
- Autophosphorylated and phosphorylated during M-phase of the cell cycle.
Phosphorylated by STK3/MST2 at Ser-909 and Thr-1079, which results in its activation.
Phosphorylation at Ser-464 by NUAK1 and NUAK2 leads to decreased protein level and is required to regulate cellular senescence and cellular ploidy.
- Protein Refseq
- NP_001257448.1
- Function
- Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "LATS1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK2186 | Rabbit Anti-LATS1 (pT1079/pT1041) Recombinant Antibody (VS3-WK2186) | WB, ELISA | Rabbit IgG |
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