Mouse Anti-PTPRC Recombinant Antibody (clone ABT-CD45)
CAT#: VS3-CJ509
This product is a mouse antibody that recognizes human PTPRC (CD45).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/if_selected.jpg
Normal Tissue
Figure 2 Appendix
Lymphoid tissue
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_3_2.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_8_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (Daudi, HEL, HL-60, JURKAT, MOLT-4, THP-1, U-266/70, U-266/84, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000081237-PTPRC
❮
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Specifications
- Immunogen
- Synthesized peptide derived from human CD45 (LCA)
- Host Species
- Mouse
- Type
- Mouse IgG2b, κ
- Specificity
- Human PTPRC (CD45)
- Species Reactivity
- Human
- Clone
- ABT-CD45
- Applications
- IHC-P
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.5% BSA, PBS.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Immunohistochemistry-Parraffin (1:100-1:500).
Target
- Alternative Names
- LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105
- Gene ID
- 5788
- UniProt ID
- P08575
- Sequence Similarities
- Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Heavily N- and O-glycosylated.
- Protein Refseq
- NP_002829.3; NP_563578.2
- Function
- Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
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|---|---|---|---|
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-245LC-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (TAB-245LC-F(E)) | ELISA, FC | Human Fab |
| TAB-246LC-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (TAB-246LC-F(E)) | ELISA, FC | Human Fab |
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| TAB-248LC-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (TAB-248LC-F(E)) | ELISA, FC | Human Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0365-CN-F(E) | Rabbit Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0365-CN-F(E)) | ELISA, FC | Rabbit Fab |
| HPAB-0366-CN-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0366-CN-F(E)) | ELISA, FC | Humanized Fab |
| FAMAB-0006-CN-F(E) | Mouse Anti-PTPRC Recombinant Antibody (clone LT40); Fab Fragment | FC | Mouse Fab |
| HPAB-0258-FY-F(E) | Mouse Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0258-FY-F(E)) | ELISA | Mouse Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-023CN | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4) | FC, IF | Mouse IgG1, κ |
| NS-023CN-F(E) | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4); Fab Fragment | FC, IF | Mouse Fab |
| NS-023CN-S(P) | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4); scFv Fragment | FC, IF | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0006-CN-S(P) | Mouse Anti-PTPRC Recombinant Antibody (clone LT40); scFv Fragment | FC | Mouse scFv |
| HPAB-0258-FY-S(P) | Mouse Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0258-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-1058-FY-F(E) | Mouse Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-1058-FY-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-0536-FY-S(P) | Human Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0536-FY-S(P)) | Inhib, FuncS | Human scFv |
| HPAB-0537-FY-S(P) | Mouse Anti-PTPRC Recombinant Antibody; scFv Fragment (HPAB-0537-FY-S(P)) | FC, Block | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY220 | AbPlus™ Anti-PTPRC Magnetic Beads (YTH54.12) | IP, Protein Purification | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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