Rabbit Anti-SP1 Recombinant Antibody (VS13-YC1100) (CAT#: VS13-YC1100)

• Immunogen
• Recombinant human SP1, aa 544-588.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human SP1

• Species Reactivity
• Human

• Applications
• WB, ICC, IF, IHC-P

• Conjugate
• NONE

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.

• Preservative
• 0.05% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/1000-1/2000
  Immunocytochemistry (ICC): 1/100-1/500
  Immunofluorescence (IF): 1/100-1/500
  Immunohistochemistry-paraffin (IHC-P): 1/50-1/200

• Alternative Names
• Sp1 Transcription Factor; Specificity Protein 1; TSFP1;

• Gene ID
• 6667

• UniProt ID
• P08047

• Long Name
• Sp1 Transcription Factor

• Sequence Similarities
• Belongs to the Sp1 C2H2-type zinc-finger protein family.

• Cellular Localization
• Nucleus; Cytoplasm

• Protein Refseq
• NP_001238754.1; NP_003100.1; NP_612482.2

• Function
• Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.
  Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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