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    Human Anti-CD28 (clone Theralizumab) scFv-Fc Chimera

    CAT#: VS-0325-FY106

    The anti-CD28 scFv-Fc antibody specifically binds to CD28, a co-stimulatory molecule critical for T cell activation. Its scFv-Fc format enhances its ability to modulate immune responses by targeting CD28. This antibody is valuable for research on T cell signaling pathways and immune checkpoint mechanisms.

    Gene Expression
    ❮
    Figure 1 Lymph node Figure 2 Tonsil Figure 3 RNA cell line category: Group enriched (Karpas-707, RPMI-8226, U-266/70, U-266/84)
    ❯

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Specificity
    • Human CD28
    • Species Reactivity
    • Human
    • Clone
    • Theralizumab
    • Applications
    • Immunoassay

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Target

    • Alternative Names
    • CD28 Molecule; CD28 Antigen; Tp44; T-Cell-Specific Surface Glycoprotein CD28; T-Cell-Specific Surface Glycoprotein; CD28 Antigen (Tp44)
    • Long Name
    • CD28 Molecule
    • Cellular Localization
    • Cell membrane
    • Post Translation Modifications
    • Phosphorylated by LCK.
      Dephosphorylated by PTPN11.
      [Isoform 3]: Tyrosine phosphorylated induced by CD40LG.
      Glycosylation at Asn37, Asn129, Asn71, Asn92, and Asn105
      Modification sites at PhosphoSitePlus
      Glycosylation from GlyGen 5 sites, 4 N-linked glycans (1 site)
    • Function
    • Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, 7568038).
      Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells.
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    Related Diseases

    Rheumatoid Arthritis Rheumatoid Arthritis
    Systemic Lupus Erythematosus Systemic Lupus Erythematosus
    Allograft Rejection Allograft Rejection
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    Graft-versus-Host Disease Graft-versus-Host Disease
    Maturity Onset Diabetes of the Young Maturity Onset Diabetes of the Young

    Downloadable Resources

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Datasheet

    Datasheet - VS-0325-FY106.pdf

    MSDS

    MSDS - VS-0325-FY106.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

    Lot Number:

    Isotype Control

    • CAT
    • Product Name

    Secondary Antibody

    • CAT
    • Product Name

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