Human Anti-CD28 Recombinant Antibody (clone FR255734); Fab Fragment (CAT#: HPAB-0132CQ-F(E))

1. Q 1: Could one use the Human Anti-CD28 Fab (FR255734) to look at mechanisms leading to T-cell co-stimulation?

   A: Yes, the FR255734 clone targets CD28, a critical co-stimulatory molecule on T-cells, enabling in-depth studies on T-cell activation and proliferation in co-stimulation pathways.

2. Q 2: Is it possible to investigate cytokine production after T-cell activation using the FR255734 clone?

   A: Yes, the FR255734 Fab fragment can be used to stimulate T-cells via CD28, allowing researchers to measure subsequent cytokine production using assays like ELISA or multiplex cytokine profiling.

3. Q 3: Is it appropriate to utilize the FR255734 antibody in humanized mouse models for preclinical research?

   A: While the FR255734 antibody is human-specific, it can be employed in humanized mouse models to study human T-cell responses, providing insights into CD28-mediated T-cell co-stimulation in a preclinical setting.

View the frequently asked questions answered by Creative Biolabs Support.