Humanized Anti-CD28 Recombinant Antibody (clone Lulizumab) (CAT#: TAB-H46)
This product is a humanized V-kappa antibody that can recognize human CD28.
Specific Inquiry
Figure 1 Mean lulizumab serum concentration profile vs time.
Mean (SD) lulizumab serum concentration profile vs time is shown on a log‐linear scale. (A) IV treatment in the SAD study; (B) SC treatment in the SAD study; (C) day 1 of the MAD study; (D) day 29 of the MAD study. IV, intravenous; MAD, multiple‐ascending dose; SAD, single‐ascending dose; SC, subcutaneous; SD, standard deviation.
Shi, R., Honczarenko, M., Zhang, S., Fleener, C., Mora, J., Lee, S. K., ... & Wang, H. (2017). Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti‐CD28 Domain Antibody Antagonist in Healthy Subjects. The Journal of Clinical Pharmacology, 57(2), 161-172.
Figure 2 lulizumab inhibited antibody production against KLH for 2 weeks, demonstrating immunosuppressive activity.
(A) Lulizumab suppression on KLH‐induced IgG response at days 8, 15, and 29 after single IV dose administration in healthy subjects in the SAD study; (B) mean CD4 cell CD28 receptor occupancy in the KLH panels of the SAD study. IgG, immunoglobulin G; IV, intravenous; KLH, keyhole limpet hemocyanin; SAD, single‐ascending dose.
Shi, R., Honczarenko, M., Zhang, S., Fleener, C., Mora, J., Lee, S. K., ... & Wang, H. (2017). Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti‐CD28 Domain Antibody Antagonist in Healthy Subjects. The Journal of Clinical Pharmacology, 57(2), 161-172.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized V-kappa
- Specificity
- Human CD28
- Species Reactivity
- Human
- Clone
- Lulizumab
- Applications
- IP, IF, FuncS, FC, Neut, ELISA, IHC
Product Property
- Purification
- Affinity Purified
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Immunoprecipitation, Immunofluorescence, Functional Assay, Flow Cytometry, Neutralization, Enzyme-linked Immunosorbent Assay, Immunohistochemistry.
Target
- Alternative Names
- Tp44; T-cell-specific surface glycoprotein CD28; CD28 molecule
- Gene ID
- 940
- UniProt ID
- P10747
Related Resources
Please refer to Lulizumab Pegol Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Lulizumab Pegol.
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CD28"
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Agonistic Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-365 | Mouse Anti-CD28 Recombinant Antibody (clone 1C6); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| HPAB-0245-FY-S(P) | Mouse Anti-CD28 Recombinant Antibody; scFv Fragment (HPAB-0245-FY-S(P)) | WB, IP, IF, FC | Mouse scFv |
| HPAB-0246-FY-S(P) | Mouse Anti-CD28 Recombinant Antibody; scFv Fragment (HPAB-0246-FY-S(P)) | FC, FuncS, ICC, IHC, IP, WB | Mouse scFv |
| HPAB-1489-FY-F(E) | Human Anti-CD28 Recombinant Antibody (clone 2E12); scFv Fragment | WB, ELISA | Human scFv |
| HPAB-1144WJ-S(P) | Human Anti-CD28 Recombinant Antibody; scFv Fragment (HPAB-1144WJ-S(P)) | ELISA | Humanized scFv |
Customer Reviews and Q&As
Customer Review
Q&As
-
Antigen-Specific Responses
Lulizumab has been crucial in studying antigen-specific T-cell responses. It helps understand how CD28 co-stimulation influences T-cell responses to specific antigens, aiding targeted immunotherapy research. -
Advanced Metabolic Studies
Lulizumab has facilitated detailed studies on T-cell metabolism. Engaging CD28 allowed us to explore metabolic pathways crucial for T-cell function and proliferation. -
Crucial for Autoimmune Research
Lulizumab has been essential in our autoimmune disease research. It helped explore CD28 signaling's role in autoimmunity, providing valuable insights into disease mechanisms.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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