This product is a humanized V-kappa antibody that can recognize human CD28.
Figure 1 Mean lulizumab serum concentration profile vs time.
Mean (SD) lulizumab serum concentration profile vs time is shown on a log‐linear scale. (A) IV treatment in the SAD study; (B) SC treatment in the SAD study; (C) day 1 of the MAD study; (D) day 29 of the MAD study. IV, intravenous; MAD, multiple‐ascending dose; SAD, single‐ascending dose; SC, subcutaneous; SD, standard deviation.
Shi, R., Honczarenko, M., Zhang, S., Fleener, C., Mora, J., Lee, S. K., ... & Wang, H. (2017). Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti‐CD28 Domain Antibody Antagonist in Healthy Subjects. The Journal of Clinical Pharmacology, 57(2), 161-172.
Figure 2 lulizumab inhibited antibody production against KLH for 2 weeks, demonstrating immunosuppressive activity.
(A) Lulizumab suppression on KLH‐induced IgG response at days 8, 15, and 29 after single IV dose administration in healthy subjects in the SAD study; (B) mean CD4 cell CD28 receptor occupancy in the KLH panels of the SAD study. IgG, immunoglobulin G; IV, intravenous; KLH, keyhole limpet hemocyanin; SAD, single‐ascending dose.
Shi, R., Honczarenko, M., Zhang, S., Fleener, C., Mora, J., Lee, S. K., ... & Wang, H. (2017). Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti‐CD28 Domain Antibody Antagonist in Healthy Subjects. The Journal of Clinical Pharmacology, 57(2), 161-172.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
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CAT | Product Name | Application | Type |
---|---|---|---|
DrMAB-981 | Mouse Anti-CD28 Recombinant Antibody (clone ANC28.1/5D10); F(ab')2 Fragment | Agonist, Stim, Neu, FC | Mouse IgG1 F(ab')2, κ |
PFBL-365 | Mouse Anti-CD28 Recombinant Antibody (clone 1C6); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
HPAB-0245-FY-F(E) | Mouse Anti-CD28 Recombinant Antibody; Fab Fragment (HPAB-0245-FY-F(E)) | WB, IP, IF, FC | Mouse Fab |
HPAB-0246-FY-F(E) | Mouse Anti-CD28 Recombinant Antibody; Fab Fragment (HPAB-0246-FY-F(E)) | FC, FuncS, ICC, IHC, IP, WB | Mouse Fab |
HPAB-1489-FY-S(P) | Human Anti-CD28 Recombinant Antibody (clone 2E12); Fab Fragment | WB, ELISA | Human Fab |
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-H46, RRID: AB_3112033)
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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