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    EGFR & CD3

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    Anti-EGFR & CD3 Products

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    • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-037CL)
      • Target: EGFR
      • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: MMAE (Monomethyl auristatin E)
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    • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-038CL)
      • Target: EGFR
      • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: MMAE (Monomethyl auristatin E)
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    • Anti-EGFR-mc-MMAF ADC (ADC-039CL)
      • Target: EGFR
      • Linker: Mc (maleimidocaproyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-EGFR-vc-PAB-MODO ADC (ADC-263CL)
      • Target: epidermal growth factor receptor (EGFR)
      • Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: MODO (monomethyldolastatin)
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    • Anti-EGFR (clone J2898A)-SMCC-DM1 ADC (ADC-047LZY)
      • Target: EGFR
      • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-EGFR (MAb806)-SMCC-DM1 ADC (ADC-110LCT)
      • Target: EGFR variant III
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-EGFRvIII-SMCC-DM1 ADC (ADC-048LZY)
      • Target: EGFRvIII
      • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-EGFR-MCC-Dox ADC (ADC-057LZY)
      • Target: EGFR
      • Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: doxorubicin
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    • Anti-EGFR-EDC/NHS-Dox ADC (ADC-058LZY)
      • Target: EGFR
      • Linker: EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
      • Drug: doxorubicin
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    • Anti-EGFR-SMCC-methotrexate ADC (ADC-059LZY)
      • Target: EGFR
      • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
      • Drug: MTX
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    • TRX4 (Gly-002CL)
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    • Cetuximab (Gly-015CL)
      • CAS number: 205923-56-4
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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.
    EGFR & CD3
    CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.
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    Related Signaling Pathways
    JAK-STAT Signaling Pathway JAK-STAT Signaling Pathway
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