Anti-EGFR-EDC/NHS-methotrexate ADC
CAT#: ADC-060LZY
This ADC product is composed of an anti-EGFR antibody conjugated via EDC/NHS linker to methotrexate (cetuximab-EDC/NHS-methotrexate). It has demonstrated a response in EGFR-positive cetuximab-resistant cancer cells treatment by a MOA (Mechanism of Action) of counteracting and competing with folic acid in cancer cells resulting in folic acid deficiency in the cells and causing their death .









Specifications
- Antibody Overview
- Cetuximab(Chimeric Human-Murine anti EGFR IgG1)
- Antibody Isotype
- IgG1
- Linker
- EDC/NHS
- Linker Class/Description
- Class: Chemically cleavable Linker-Acid-labile linker
Description: Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.
- Drug
- MTX
- Drug Class/Description
- Class: methotrexate
Description: Methotrexate (MTX) and formerly known as amethopterin, is an antimetabolite and antifolate drug.
It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid
Target
- Introduction
- The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
- Alternative Names
- EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog;
- Gene ID
- 1956
- UniProt ID
- P00533
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Related Diseases
Related Signaling Pathways
Downloadable Resources
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Datasheet
MSDS
COA
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See other products for "EGFR"
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-750 | Anti-EGFR/HER1 Recombinant Antibody (TAB-750) | Neut, ELISA, IF, IP, FuncS, FC, WB | IgG1 - kappa |
TAB-003 | Anti-Human EGFR Recombinant Antibody (Cetuximab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
TAB-272MZ | Human Anti-EGFR Recombinant Antibody (TAB-272MZ) | FuncS | Chimeric (mouse/human) IgG |
TAB-302MZ | Human Anti-EGFR Recombinant Antibody (TAB-302MZ) | ELISA | Chimeric (mouse/human) IgG1 |
PABX-051-F (E) | Recombinant Mouse Anti-EGFR Antibody Fab Fragment (Matuzumab) | WB, Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-165 | Anti-Human EGFR Recombinant Antibody (Matuzumab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 |
TAB-710 | Anti-EGFR Recombinant Antibody (Nimotuzumab) | ELISA, IP, FC, FuncS, Neut, IF, IHC | IgG1 - kappa |
TAB-228CL | Anti-Human EGFR Recombinant Antibody (ABT-806) | WB, IHC | Antibody |
TAB-274MZ-S(P) | Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-274MZ-S(P)) | FC | Humanized scFv |
PABX-052 | Recombinant Human Anti-EGFR Antibody (PABX-052) | WB, ELISA, FuncS, IB, FC, SPR, Apop | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0242MC | Rabbit Anti-Human EGFR (phospho Y1092) Antibody | IHC, WB | |
MOB-0243MC | Rabbit Anti-Human EGFR (phospho Y1068) Antibody | IHC, WB | |
PABW-171 | Mouse Anti-EGFR Recombinant Antibody (PABW-171) | WB | Mouse IgG |
TAB-477CQ | Human Anti-EGFR Recombinant Antibody (clone Laprituximab) | ELISA, IHC, FC, IP, IF, WB | Chimeric (mouse/human) IgG1, κ |
MOB-052LC | Mouse Anti-EGFR Recombinant Antibody (clone 7H7) | WB, IP | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0564CL | Mouse Anti-EGFR Recombinant Antibody (TAB-0564CL) | ELISA | Mouse IgG |
TAB-0565CL | Mouse Anti-EGFR Recombinant Antibody (TAB-0565CL) | ELISA | Mouse IgG |
TAB-301MZ-S(P) | Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-301MZ-S(P)) | ELISA | Mouse scFv |
TAB-303MZ-S(P) | Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-303MZ-S(P)) | ELISA | Mouse scFv |
TAB-304MZ-S(P) | Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-304MZ-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-288MZ-S(P) | Human Anti-EGFR Recombinant Antibody (TAB-288MZ-S(P)); scFv Fragment | ADCC assay | Human scFv |
TAB-289MZ-S(P) | Human Anti-EGFR Recombinant Antibody (TAB-289MZ-S(P)); scFv Fragment | ADCC assay | Human scFv |
TAB-290MZ-S(P) | Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-290MZ-S(P)) | FC | Human scFv |
TAB-291MZ-S(P) | Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-291MZ-S(P)) | FC | Human scFv |
TAB-292MZ-S(P) | Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-292MZ-S(P)) | In vitro binding assay | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-055LC | Recombinant Anti-Human EGFR Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Chimeric antibody (mouse/human) |
Gly-144LC | Recombinant Anti-Human EGFR Antibody (Fc glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-055LC-1 | Recombinant Anti-Human EGFR Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-167LC | Recombinant Anti-Human EGFR Antibody (Non-glycosylated) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0183MZ | Chicken Anti-EGFR Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC773 | A*0201/Human EGFR (YLNTVQPTCV) MHC Tetramer | FCM | |
MHC-LC4545 | PE-DQB1*03:02/Human EGFR (SRALEEKKGNYVVTHG) MHC Tetramer | FCM | |
MHC-YF409 | A*02:01/Human EGF-R-479 (KLFGTSGQKT) MHC Pentamer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-722CQ | Rabbit Anti-EGFR Recombinant Antibody (clone CBL1011) | Neut | Rabbit IgG |
NEUT-723CQ | Mouse Anti-EGFR Recombinant Antibody (clone CBL931) | WB, IP, IHC, ICC, Neut | Mouse IgG1 |
NEUT-724CQ | Rabbit Anti-EGFR Recombinant Antibody (NEUT-724CQ) | IF, FC, WB, IP, Neut | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1101 | Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone DS1101AB) | IHC-P | Rabbit IgG |
MOR-4570 | Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone TH82DS) | ELISA | Rabbit IgG |
MOR-4571 | Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone TH83DS) | WB, IF, ICC, FC | Rabbit IgG |
MOR-4675 | Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone TH189DS) | WB, IF, ICC, FC | Rabbit IgG |
MOR-0033-FY | Rabbit Anti-EGFR Recombinant Antibody (clone AFY0004) | ICC, IHC, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0010-YC-S(P) | Mouse Anti-EGFR Recombinant Antibody (clone L211C); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-0011-YC-S(P) | Human Anti-EGFR Recombinant Antibody (clone Pep 1); scFv Fragment | FC | Human scFv |
HPAB-0012-YC-S(P) | Human Anti-EGFR Recombinant Antibody (clone Pep 2); scFv Fragment | FC | Human scFv |
HPAB-0013-YC-S(P) | Human Anti-EGFR Recombinant Antibody (clone Pep 3); scFv Fragment | FC | Human scFv |
HPAB-0014-YC-S(P) | Human Anti-EGFR Recombinant Antibody (clone Pep 4); scFv Fragment | FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-165 | Afuco™ Anti-EGFR ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-165) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-464CQ | Afuco™ Anti-EGFR ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-464CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-003 | Afuco™ Anti-EGFR ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-003) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-040 | Afuco™ Anti-EGFR ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-040) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-119 | Afuco™ Anti-EGFR ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-119) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-2194LY-F(E) | Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (HPAB-2194LY-F(E)) | ELISA, WB | Mouse Fab |
HPAB-2195LY-F(E) | Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (HPAB-2195LY-F(E)) | ELISA | Mouse Fab |
HPAB-2196LY-F(E) | Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (HPAB-2196LY-F(E)) | ELISA | Mouse Fab |
HPAB-2197LY-F(E) | Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (HPAB-2197LY-F(E)) | ELISA | Mouse Fab |
HPAB-2198LY-F(E) | Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (HPAB-2198LY-F(E)) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-AP881-YC | Recombinant Llama Anti-EGFR Single Domain Antibody (HPAB-AP881-YC) | ELISA, FC, IP, FuncS | Llama VHH |
HPAB-AP882-YC | Recombinant Llama Anti-EGFR Single Domain Antibody (HPAB-AP882-YC) | ELISA | Llama VHH |
HPAB-AP883-YC | Recombinant Llama Anti-EGFR Single Domain Antibody (HPAB-AP883-YC) | ELISA | Llama VHH |
HPAB-AP884-YC | Recombinant Llama Anti-EGFR Single Domain Antibody (HPAB-AP884-YC) | ELISA | Llama VHH |
HPAB-AP885-YC | Recombinant Llama Anti-EGFR Single Domain Antibody (HPAB-AP885-YC) | ELISA | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0424-XY84 | AbPlus™ Anti-EGFR Magnetic Beads (pSEX81-6) | IP, Protein Purification |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0924-YC32 | Mouse Anti-EGFR Recombinant Antibody (VS-0924-YC32) - Cancer Stem Cell Marker | IHC, WB | Mouse IgG1 |
VS-0924-YC35 | Rabbit Anti-EGFR Antibody (VS-0924-YC35) - Cancer Stem Cell Marker | IHC, WB, IF | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-1024-XY177 | Mouse Anti-NHP EGFR Recombinant Antibody (clone 225) | IF, IP | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0125-FY28 | Human Anti-EGFR (clone ABT-806) scFv-Fc Chimera | FC, Cyt | Human IgG1, scFv-Fc |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0225-XY102 | CytoStream™ Mouse Anti-EGFR Recombinant Antibody (VS-0225-XY102) | FC | Mouse IgG1, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0325-XY735 | Anti-EGFR Immunohistochemistry Kit | IHC | |
VS-0525-XY2183 | Anti-Mouse EGFR Immunohistochemistry Kit | IHC | |
VS-0525-XY2182 | Anti-Human EGFR Immunohistochemistry Kit | IHC |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-YC340 | Recombinant Anti-EGFR Vesicular Antibody, EV Displayed (VS-0425-YC340) | ELISA, FC, Neut, Cell-uptake |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-YC65 | Recombinant Anti-EGFR (AA 269-278 x AA 526-535) Biparatopic Antibody, Tandem scFv (Clone Pep 2 x Clone Pep 3) | FC | Tandem scFv |
VS-0525-YC66 | Recombinant Anti-EGFR (AA 582-591 x AA 606-614) Biparatopic Antibody, Tandem scFv (Clone Pep 4 x Clone Pep 1) | FC | Tandem scFv |
VS-0525-YC68 | Recombinant Anti-EGFR (AA 526-535 x AA 600-605) Biparatopic Antibody, Tandem scFv (Clone Pep 3 x Clone Pep 5) | FC | Tandem scFv |
VS-0525-YC213 | Recombinant Anti-EGFR (Domain II x Domain III) Biparatopic Antibody, Tandem scFv | ELISA, FC, IF, IHC, IP | Tandem scFv |
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