Products

cetuximab-EDC/NHS-Dox (ADC-058LZY)

This ADC product is composed of an anti-EGFR antibody conjugated via EDC/NHS linker to Dox (cetuximab-EDC/NHS-Dox). It has demonstrated a response in EGFR-positive cetuximab-resistant cancer cells treatment by a MOA (Mechanism of Action) of inhibiting Topoisomerase II and causing DNA damage.      

  • Datasheet

Specifications
Antibody Overview
Cetuximab(Chimeric Human-Murine anti EGFR IgG1)
Antibody Isotype
IgG1
Linker
EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
Linker Class/Description
Class: Chemically cleavable Linker-Acid-labile linker
Description: Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.
Drug
doxorubicin
Drug Class/Description
Class: Doxorubicin
Description: Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.
Target
Introduction
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Entrez Gene ID
1956
UniProt ID
P00533

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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