HLA-A & CD55

HLA-A (Human Leukocyte Antigen A) is a gene that encodes a major component of the MHC (Major Histocompatibility Complex) class I molecules. These molecules are critical for the immune system to distinguish self from non-self. Specifically, HLA-A molecules present endogenous peptides, such as those derived from viral infections or cancer cells, to cytotoxic T cells. This presentation helps the immune system recognize and attack infected or malignant cells. The variability in HLA-A alleles plays a significant role in determining susceptibility to infections, autoimmune diseases, and the outcome of organ transplants. Polymorphisms in this gene are often linked to diseases such as ankylosing spondylitis and various viral infections like HIV.

CD55 (CD55 Molecule (Cromer Blood Group)) is a Protein Coding gene. Diseases associated with CD55 include Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy and Blood Group, Cromer System. Among its related pathways are Creation of C4 and C2 activators and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include lipid binding and virus receptor activity. An important paralog of this gene is C4BPA.