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HNF4A
Loading...Anti-HNF4A Products
- Rabbit Anti-HNF4A Recombinant Antibody (clone CBACN-280) (MRO-0757-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IHC, IP
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- Recombinant Mouse Anti-Human HNF4A Antibody (MOB-2375MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC, IF, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, ICC, IHC-P, IP, WB
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- Rabbit Anti-HNF4A Recombinant Antibody (VS13-YC540) (VS13-YC540)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P
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- Anti-HNF4A Immunohistochemistry Kit (VS-0525-XY3225)
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- Species Reactivity: Human
- Target: HNF4A
- Application: IHC
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- Anti-Mouse HNF4A Immunohistochemistry Kit (VS-0525-XY3226)
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- Species Reactivity: Human, Mouse, Rat
- Target: HNF4A
- Application: IHC
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- Human Anti-HNF4A Recombinant Antibody (clone 2506W1334) (VS-0625-FY1439)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, Spiked IP, IF
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- Anti-Rat HNF4A Immunohistochemistry Kit (VS-0525-XY3227)
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- Species Reactivity: Human, Mouse, Rat
- Target: HNF4A
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
Protein class
Disease related genes, Human disease related genes, Nuclear receptors, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Distal enterocytes, Hepatocytes, Proximal tubular cells, Proximal enterocytes, Undifferentiated cells, Paneth cells, Intestinal goblet cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (CACO-2, Hep G2, OE19)
Interaction
Homodimerization is required for HNF4-alpha to bind to its recognition site (PubMed:14982928). Interacts with CLOCK, ARNTL, CRY1, CRY2, PER1 and PER2 (PubMed:30530698). Interacts with NR0B2/SHP; the resulting heterodimer is transcriptionnally inactive (PubMed:28128295). Interacts with DDX3X; this interaction disrupts the interaction between HNF4 and NR0B2 that forms inactive heterodimers and enhances the formation of active HNF4 homodimers (PubMed:28128295).
Molecular function
Activator, DNA-binding, Receptor, Repressor
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway
Related Diseases
Type I Diabetes Mellitus
