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Anti-IL2RA Recombinant Antibody Products

Anti-IL2RA Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs provides a whole spectrum of premium anti-IL2RA recombinant antibodies. These antibodies are designed for optimal performance. Applying our superior technology guarantees incredible specificity, stability, and effectiveness in these antibodies, thereby making them essential tools for researchers and developers focused on targeted cancer medicines.

IL2RA: A Key Therapeutic Target for Autoimmune Diseases and Cancer

The interleukin-2 receptor alpha chain (CD25) functions as a critical component required for the assembly of high-affinity interleukin-2 receptors. Elevated expression of this receptor subunit, particularly its soluble isoform (sCD25), demonstrates strong correlations with both autoimmune disorders and malignant conditions. This soluble variant is generated during immune activation and has become an important biomarker for tracking disease trajectories and therapeutic responses. The molecule shows particular relevance in pathological immune hyperactivation scenarios, including cytokine release syndromes that may progress to multi-organ dysfunction. These biological properties position CD25/IL-2RA as a compelling molecular target for innovative cancer therapies.

Alternative Names

Interleukin 2 receptor subunit alpha; CD25; interleukin-2 receptor alpha chain; Tac antigen; P55; IDDM10; IL2R; TCGFR; IMD41.

Background

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.

Anti-IL2RA rAb Products

With a great range of recombinant anti-IL2RA antibodies, each meticulously crafted for extraordinary specificity and affinity, Creative Biolabs offers varied forms of our antibodies, allowing us to satisfy varied study needs. These antibodies, which use our sophisticated platform, are modern instruments to further immunology, cancer biology, and allied fields of study as well as help to produce next-generation medicines.

Table 1. Featured anti-IL2RA recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
AFC-TAB-023 Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Daclizumab), ADCC Enhanced Human Human ADCC enhanced antibody ELISA, Neut, IF, IP, FC, FuncS
AFC-TAB-004 Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Basiliximab), ADCC Enhanced Human Chimeric (mouse/human) ADCC enhanced antibody IF, IP, Neut, FuncS, ELISA, FC
TAB-023 Anti-Human CD25 Recombinant Antibody (Daclizumab) Human Mouse IgG1 - kappa ELISA, Neut, IF, IP, FC, FuncS, MRI
TAB-004 Anti-Human CD25 Recombinant Antibody (Basiliximab) Human Mouse IgG1 - kappa FC, IP, ELISA, Neut, FuncS, IF, WB, etc.
ZG-0100J Mouse Anti-IL2RA Recombinant Antibody (clone Q22) Human Mouse IgG IHC-P, IF (paraffin section)

Creative Quality Control

Creative Biolabs provides a diverse array of recombinant antibodies that are specifically designed to target IL2RA. These antibodies are meticulously crafted and subjected to rigorous testing to guarantee their superior quality. Our first-rate facilities and knowledgeable researchers are committed to precisely targeting IL2RA by means of each antibody. Our antibodies are a great tool for field-based researchers as they undergo extensive validation procedures and exhibit exceptional specificity, robust binding affinity, and great performance for a variety of study uses.

Fig.1 HPLC analysis. (Creative Biolabs Original)Fig.1 HPLC analysis of anti-CD25/IL2RA antibody
(Cat# TAB-023, Creative Biolabs).

Fig.2 SDS-PAGE analysis. (Creative Biolabs Original)Fig.2 SDS-PAGE analysis of anti-CD25/IL2RA antibody
(Cat# TAB-023, Creative Biolabs).

Fig.3 IHC analysis. (Creative Biolabs Original)Fig.3 IHC analysis of anti-IL2RA antibody
(Cat# ZG-0100J, Creative Biolabs).

Fig.4 IHC analysis. (Creative Biolabs Original)Fig.4 IHC analysis of anti-IL2RA antibody
(Cat# ZG-0100J, Creative Biolabs).

Customer Reviews

Excellent
Da***oi***x
Rat Anti-IL2RA Recombinant Antibody (clone YTH 906.9.21) (HPAB-1536WJ)
In my ELISA tests, I recently employed the anti-IL2RA antibody from Creative Biolabs; the results really make me happy. The antibody consistently produced significant signals throughout all the tested samples by showing great specificity and high binding affinity to the target. The protocol provided was straightforward, and I was able to achieve reproducible readings with minimal background noise. This antibody truly enhanced the reliability of my assay, making it an invaluable tool for my ongoing research in immunology.
20/Mar/2023
Excellent
Go***db***g
Mouse Anti-IL2RA Recombinant Antibody (clone Q22) (ZG-0100J)
I am thrilled with the performance of the anti-IL2RA antibody in my immunofluorescence experiments. The staining was remarkably clear and precise, allowing me to visualize IL2RA expression on the cell surfaces effectively. The antibody produced a brilliant fluorescent signal, and the background staining was negligible, which is critical for accurate interpretation of results. Furthermore, Creative Biolabs' superb customer service guaranteed that I received the appropriate product for my unique need. This antibody has significantly contributed to my understanding of IL-2RA in cellular interactions.
15/Oct/2023
Excellent
Du***a
Rabbit Anti-IL2RA Recombinant Antibody (clone R03-3E2) (VS3-XY3393)
My immunohistochemical experience with Creative Biolabs' anti-IL2RA antibody has been rather favorable. Perfect localization of the target protein was made possible by the antibody's outstanding, unambiguous, and unique staining of IL2RA throughout a spectrum of tissue samples. Following their optimized protocol ensured a smooth and efficient workflow, with highly reproducible results across multiple experiments. My study on the function of IL-2RA in cancer pathology has been much advanced by this consistent, high-quality antibody, which I want to keep using in future studies.
17/Nov/2024

rAb Production

Creative Biolabs delivers a reliable assortment of high-quality anti-IL2RA antibodies, meticulously produced with state-of-the-art genetic engineering techniques.

Featured Anti-IL2RA Recombinant Antibody Production PlatformsFig.5 Milligram-scale. (Creative Biolabs Original)
Fig.5 Milligram-scale anti-IL2RA recombinant antibody production.

Fig.6 Gram-scale. (Creative Biolabs Original)Fig.6 Gram-scale anti-IL2RA recombinant antibody production.

rAb Modalities

Creative Biolabs offers an extensive selection of premium anti-IL2RA recombinant antibodies available in multiple formats, designed to accommodate the diverse needs of researchers worldwide.

Fig.7 IL2RA antibody production and modalities. (Creative Biolabs Original)Fig.7 Full-length anti-IL2RA recombinant antibody production and modalities.

IL2RA-Targeted Drug Information

Table 2. Public drug targeting IL2RA.

Company Research phase Classification Condition
Cerimon
Novartis (Originator)
Launched - 1998 Chimeric Monoclonal Antibodies Cytokine release syndrome
Immunosuppression
Inflammatory bowel disease
Transplant rejection
Transplant rejection, kidney
Ulcerative colitis
Uveitis
Biogen (Originator)
Roche (Originator)
Shionogi
Launched - 1992 Cancer Immunotherapy
IL-2
Polypeptides, from 41 AA
Recombinant proteins
Angiosarcoma
Cancer, colorectal, metastatic
Abbott
AbbVie
Biogen
Biogen Idec (Biogen)
National Cancer Institute
National Eye Institute (NEI)
PDL BioPharma (Originator)
Protein Design Labs (PDL BioPharma)
Roche
UCB
Withdrawn - 2018 Cancer Immunotherapy
Humanized Monoclonal Antibodies
Asthma
Diabetes type 1
Eye Disorders
Hodgkin lymphoma
Immunosuppression
Leukemia-lymphoma, adult T-cell
Multiple sclerosis
Multiple sclerosis, relapsing-remitting
Psoriasis
Transplant rejection
Transplant rejection, heart
Transplant rejection, kidney
Ulcerative colitis
Uveitis
Biotest (Originator)
ElsaLys Biotech
Jazz Pharmaceuticals
OPi (Jazz Pharmaceuticals)
Pre-Registered Murine Monoclonal Antibodies Graft-versus-host disease
Mabpharm
Mabtech (Sinomab)
Sinomab (Originator)
Sorrento Therapeutics
TNK Therapeutics
Phase III Chimeric Monoclonal Antibodies
Follow-on Products
Transplant rejection
Second Xiangya Hosp Central South Univ (Originator) Phase II IL-2
Polypeptides, from 41 AA
Recombinant proteins
Pemphigus vulgaris
Urticaria
Lilly
Nektar Therapeutics (Originator)
Phase II IL-2
Pegylated Drugs
Polypeptides, from 41 AA
Recombinant proteins
Alopecia areata
Atopic dermatitis
Autoimmune disease
Crohn's disease
Graft-versus-host disease
Plaque psoriasis
Rheumatoid arthritis
Systemic lupus erythematosus
Ulcerative colitis
Bioniz Therapeutics (Equillium)
Equillium (Originator)
Phase II Pegylated Drugs
Peptides
Alopecia areata
Atopic dermatitis
Cutaneous T-cell lymphoma
HTLV-1-associated myelopathy-tropical spastic paraparesis
Large granular lymphocytic leukemia
Lymphocytic leukemia
Vitiligo
University of California Los Angeles (Originator) Phase II Transplant rejection
National Cancer Institute (Originator) Phase II Fusion Proteins
Immunotoxins
Polypeptides, from 41 AA
Toxins
Chronic lymphocytic leukemia
Cutaneous T-cell lymphoma
Hairy cell leukemia
Leukemia
Lymphoma
Melanoma

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

As a veteran leader in the antibody field, Creative Biolabs continues to introduce cutting-edge technologies and expertise to improve product characteristics and performance. If you are looking for reliable IL2RA antibody products, please feel free to contact us for inquiries.

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