MSLN
Mesothelin is a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas.
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC, IHC-Fr, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ELISA, IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: FuncS
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) Fab
- Application: FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: FuncS
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) Fab
- Application: FuncS
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Llama VHH
- Application: ELISA, FC, IF
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- Species Reactivity: Human
- Type: Llama VHH
- Application: ELISA, FC, IF
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- Species Reactivity: Human
- Type: Rabbit scFv
- Application: FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: FuncS
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- Species Reactivity: Human
- Type: Rabbit scFv
- Application: FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: FuncS
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) IgG
- Application: FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: FuncS
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) IgG
- Application: FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: FuncS
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- Species Reactivity: Human
- Type: Rabbit scFv
- Application: FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: FuncS
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- Species Reactivity: Human
- Type: Rabbit scFv
- Application: FuncS
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) IgG
- Application: FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: FuncS
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) IgG
- Application: FuncS
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC, SPR
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FC
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- Species Reactivity: Mouse
- Type: Human scFv
- Application: ELISA, FC, Neut
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC, ELISA
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: IP, IF, FuncS, FC, Neut, ELISA
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: ELISA, FC, IHC, WB
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, IHC, WB
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, IHC, WB
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, IHC, WB
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- Species Reactivity: Mouse
- Type: Human Fab
- Application: ELISA, FC, Neut
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: ELISA, FC, IHC, WB
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: ELISA, FC, IHC, WB
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: WB, ELISA, FC
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: WB, ELISA, FC
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- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, FC, IHC, WB
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- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, FC, IHC, WB
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- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, FC, IHC, WB
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA, FC
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: WB, ELISA, FC
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG1
- Application: WB, ELISA, FC
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG1
- Application: WB, ELISA, FC
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG1
- Application: WB, ELISA, FC
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- Species Reactivity: Human
- Type: Human scFv
- Application: WB, ELISA, FC
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- Species Reactivity: Mouse
- Type: Human IgG, λ
- Application: ELISA, FC, Neut
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- Target: mesothelin
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: IL12-scFv
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA, FC
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA, FC
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- Species Reactivity: Human
- Type: Human IgG1
- Application: WB, ELISA, FC
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- Target: mesothelin
- Linker: cleavable di-peptide linker
- Drug: Duocarmycins
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, ELISA
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC, WB, ELISA
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC, WB, ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, WB, ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, WB, ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: FC, ELISA
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- Species Reactivity: Human
- Type: Human IgG
- Application: FC, WB, ELISA
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- Species Reactivity: Human
- Type: Human scFv
- Application: FC, WB, ELISA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC, WB, ELISA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC, WB, ELISA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC, WB, ELISA
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- Species Reactivity: Human
- Type: Human IgG
- Application: FC, WB, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, WB, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, WB, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, WB, ELISA
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Species Reactivity: Human, Mouse
- Type: Human scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC
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- Species Reactivity: Human, Mouse
- Type: Human IgG1, λ
- Application: ELISA, FC, FACS, Inhib
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- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: ELISA, FuncS, FC, SPR, Inhib
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- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, FuncS, Activ, FC
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- Target: MSLN
- Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Drug: MMAF (monomethyl auristatin F)
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- Target: mesothelin
- Linker: disulfide
- Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4- methyl-1-oxopentyl)maytansine)
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- Target: MSLN
- Linker: protease-cleavable peptide linker
- Drug: MMAE (Monomethyl auristatin E)
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- Target: Mesothelin
- Linker: Cleavable, disulfide
- Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Species Reactivity: Mouse
- Application: Cytotoxicity assay, Function study
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Target: MSLN
- Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Drug: MMAE (monomethyl auristatin E)
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- Target: MSLN
- Linker: mc (maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
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- Target: mesothelin
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
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- Species Reactivity: Human
- Type: Llama VHH
- Application: WB, IHC, FC, FuncS
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