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MYOD1
Anti-MYOD1 Recombinant Antibody Products
- Mouse Anti-MYOD1 Recombinant Antibody (clone 1C8) (VS3-XY1131)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: IHC, WB, ELISA
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- Species Reactivity: Human, Mouse, Rat, Chicken, Pig
- Type: Mouse IgG2a
- Application: ELISA, WB, IP, IF, IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Skeletal myocytes, Spermatogonia)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (RH-30)
Interaction
Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1. Interacts with DDX5. Interacts with CHD2. Interacts with TSC22D3 (By similarity). Interacts with SETD3 (By similarity). Interacts with P-TEFB complex; promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation (By similarity) (PubMed:12037670). Interacts with CSRP3. Interacts with NUPR1 (By similarity).
Molecular function
Activator, Developmental protein, DNA-binding
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