NFKB1

AbPlus Recombinant Antibody Products Formats

Anti-NFKB1 Recombinant Antibody Products

Chicken Anti-NFKB1 Polyclonal IgY (BRD-0391MZ)
- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
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Hi-Affi™ Recombinant Rabbit Anti-NFKB1 Monoclonal Antibody (DS2433AB) (MOR-2433)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC-P, ICC, FC
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Hi-Affi™ Recombinant Rabbit Anti-NFKB1 Monoclonal Antibody (TH19DS) (MOR-4511)
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC
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Rabbit Anti-NFKB1 Recombinant Antibody (clone AFY0067) (MOR-0096-FY)
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: ICC, IHC-P, WB
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For Research Use Only. Not For Clinical Use.

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]

Protein class

Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, RAS pathway related proteins, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Langerhans cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Component of the NF-kappa-B p65-p50 complex (PubMed:1740106). Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the NF-kappa-B p50-c-Rel complex (PubMed:15102766, PubMed:8152812). Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3 (PubMed:10469655). Also interacts with MAP3K8 (PubMed:9950430, PubMed:15485931). NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity (PubMed:11094166). Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding (PubMed:11468175, PubMed:12393603). Interacts with SPAG9 and UNC5CL (PubMed:14769797, PubMed:14743216). NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50 (PubMed:13679070). NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2 (PubMed:15169888). Interacts with GSK3B; the interaction prevents processing of p105 to p50 (PubMed:12871932). NFKB1/p50 interacts with NFKBIE (PubMed:9315679). NFKB1/p50 interacts with NFKBIZ (By similarity). Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (By similarity). Directly interacts with MEN1 (PubMed:11526476). Interacts with HIF1AN (PubMed:17003112). Interacts with FEM1A; interaction is direct (By similarity).

Molecular function

Activator, DNA-binding

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Related Signaling Pathways

BCR Signaling Pathway