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NPM1
Loading...Anti-NPM1 Products
- AbPlus™ Anti-NPM1 Magnetic Beads (VS-0724-YC431) (VS-0724-YC431)
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- Target: NPM1
- Target Species: Human
- Application: IP, Protein Purification
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- Species Reactivity: Human, Rabbit, Porcine, Rat, Mouse
- Type: Mouse IgG1
- Application: ELISA, WB, ICC
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- Mouse Anti-NPM1 Recombinant Antibody (MOB-0146F) (MOB-0146F)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
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- Species Reactivity: Human, Mouse, Rat, Bovine, Pig, Rabbit
- Type: Mouse IgG
- Application: WB, IF
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- A*02:01/Human NPM1 (AIQDLCLAV) MHC Pentamer (MHC-YF593)
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- Class: Class I
- Antigen: NPM1
- Antigen Species: Human
- Peptide: AIQDLCLAV
- Conjugate: Unlabeled, Biotin, R-PE, APC
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- A*02:01/Human NPM1 (AIQDLCVAV) MHC Pentamer (MHC-YF594)
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- Class: Class I
- Antigen: NPM1
- Antigen Species: Human
- Peptide: AIQDLCVAV
- Conjugate: Unlabeled, Biotin, R-PE, APC
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- Human Anti-NPM1 Recombinant Antibody (clone NA24) (FAMAB-1229CQ)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: IP, WB, IF, IHC
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- Human Anti-NPM1 Antibody (clone NA24), mRNA (FAMAB-1229CQ-mRNA)
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- Species Reactivity: Human
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- Recombinant Anti-human NPM1 Antibody (MOB-711)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, IP, FuncS
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- Recombinant Anti-human NPM1 Antibody Fab Fragment (MOB-711-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, FuncS
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- Recombinant Anti-human NPM1 Antibody scFv Fragment (MOB-711-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, IHC, FuncS
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- Mouse Anti-NHP NPM1 Recombinant Antibody (clone 7H10B9) (VS-1024-XY346)
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- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB, IHC, IF, ELISA
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- Recombinant Human Anti-human NPM1 Antibody Fab Fragment (MHH-711-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: FC, IP, FuncS
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- Recombinant Human Anti-human NPM1 Antibody scFv Fragment (MHH-711-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: FC, Neut, Biosensors, FuncS
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- Mouse Anti-NPM1 Monoclonal Antibody (VS7-0425-WR495) (VS7-0425-WR495)
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- Species Reactivity: Human, Monkey
- Type: Mouse IgG
- Application: WB, IHC-P, IF, ICC, ELISA
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- Anti-NPM1 Immunohistochemistry Kit (VS-0325-XY1511)
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- Species Reactivity: Human, Rat
- Target: NPM1
- Application: IHC
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- Anti-Mouse NPM1 Immunohistochemistry Kit (VS-0525-XY4922)
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- Species Reactivity: Human, Mouse, Rat
- Target: NPM1
- Application: IHC
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- Mouse Anti-NPM1 Recombinant Antibody (VS7-0425-WR494) (VS7-0425-WR494)
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- Species Reactivity: Human, Mouse, Rat, Bovine, Pig, Rabbit
- Type: Mouse IgG
- Application: WB, IF, ICC
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For Research Use Only. Not For Clinical Use.
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Decamer formed by two pentameric rings associated in a head-to-head fashion (By similarity). Disulfide-linked dimers under certain conditions (PubMed:25818168). The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70 (By similarity). Interacts with NSUN2 and SENP3. Interacts with the methylated form of RPS10. Interacts (via N-terminal domain) with APEX1; the interaction is RNA-dependent and decreases in hydrogen peroxide-damaged cells. Interacts with isoform 1 of NEK2. Interacts with ROCK2 and BRCA2. Interacts with RPGR. Interacts with CENPW. Interacts with EIF2AK2/PKR. Interacts with CEBPA (isoform 4) (PubMed:20075868). Interacts with DDX31; this interaction prevents interaction between NPM1 and HDM2 (PubMed:23019224). Interacts with MYC; competitive with NOP53 (PubMed:25956029). Interacts with NOP53; the interaction is direct and competitive with MYC (PubMed:25956029). Interacts with LRRC34 (By similarity). Interacts with RRP1B (PubMed:19710015, 20926688). Interacts with NPM3 (PubMed:22362753). Interacts with ALKBH2 (PubMed:23972994). Interacts with TTF1 (via C-terminal region) (By similarity). (Microbial infection) Interacts with hepatitis delta virus S-HDAg. (Microbial infection) Interacts with HTLV1 Rex protein (via N-terminal nuclear localization signal).
Molecular function
Chaperone, RNA-binding
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