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NPM1
The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Decamer formed by two pentameric rings associated in a head-to-head fashion (By similarity). Disulfide-linked dimers under certain conditions (PubMed:25818168). The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70 (By similarity). Interacts with NSUN2 and SENP3. Interacts with the methylated form of RPS10. Interacts (via N-terminal domain) with APEX1; the interaction is RNA-dependent and decreases in hydrogen peroxide-damaged cells. Interacts with isoform 1 of NEK2. Interacts with ROCK2 and BRCA2. Interacts with RPGR. Interacts with CENPW. Interacts with EIF2AK2/PKR. Interacts with CEBPA (isoform 4) (PubMed:20075868). Interacts with DDX31; this interaction prevents interaction between NPM1 and HDM2 (PubMed:23019224). Interacts with MYC; competitive with NOP53 (PubMed:25956029). Interacts with NOP53; the interaction is direct and competitive with MYC (PubMed:25956029). Interacts with LRRC34 (By similarity). Interacts with RRP1B (PubMed:19710015, 20926688). Interacts with NPM3 (PubMed:22362753). Interacts with ALKBH2 (PubMed:23972994). Interacts with TTF1 (via C-terminal region) (By similarity). (Microbial infection) Interacts with hepatitis delta virus S-HDAg. (Microbial infection) Interacts with HTLV1 Rex protein (via N-terminal nuclear localization signal).
Molecular function
Chaperone, RNA-binding
More Types Infomation
- A*02:01/Human NPM1 (AIQDLCVAV) MHC Pentamer (MHC-YF594)
-
- Class: Class I
- Antigen: NPM1
- Antigen Species: Human
- Peptide: AIQDLCVAV
- Conjugate: Unlabeled, Biotin, R-PE, APC
- A*02:01/Human NPM1 (AIQDLCLAV) MHC Pentamer (MHC-YF593)
-
- Class: Class I
- Antigen: NPM1
- Antigen Species: Human
- Peptide: AIQDLCLAV
- Conjugate: Unlabeled, Biotin, R-PE, APC
- Human Anti-NPM1 Antibody (clone NA24), mRNA (FAMAB-1229CQ-mRNA)
-
- Species Reactivity: Human
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC/IF, IHC-P, IP, WB
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P
- Recombinant Human Anti-human NPM1 Antibody Fab Fragment (MHH-711-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: FC, IP, FuncS
- Recombinant Anti-human NPM1 Antibody scFv Fragment (MOB-711-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, IHC, FuncS
- Recombinant Anti-human NPM1 Antibody Fab Fragment (MOB-711-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, FuncS
- Recombinant Anti-human NPM1 Antibody (MOB-711)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, IP, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, FC, FuncS
- Recombinant Human Anti-human NPM1 Antibody scFv Fragment (MHH-711-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: FC, Neut, Biosensors, FuncS
- Mouse Anti-NPM1 Recombinant Antibody (MOB-0146F) (MOB-0146F)
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
- Human Anti-NPM1 Recombinant Antibody (clone NA24) (FAMAB-1229CQ)
-
- Species Reactivity: Human
- Type: Human IgG1
- Application: IP, WB, IF, IHC
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC-P
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB, ICC
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB
-
- Species Reactivity: Human, Rabbit, Porcine, Rat, Mouse
- Type: Mouse IgG1
- Application: ELISA, WB, ICC
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, IHC
-
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IHC-P
-
- Species Reactivity: Human, Monkey
- Type: Mouse IgG
- Application: WB, IHC, IF, ELISA
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