A*0201/Human EGFR (YLNTVQPTCV) MHC Tetramer
CAT#: MHC-LC773
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of EGFR-derived peptide of YLNTVQPTCV sequence covering 1138-1147 and A*0201 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cell junctions.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/144_E9_2_selected.jpg
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Specifications
- Allele
- A*0201
- Class
- Class I
- MHC Species
- Human
- Antigen
- EGFR
- Antigen Species
- Human
- Peptide
- YLNTVQPTCV
- Range
- 1138-1147
- Application
- FCM
Target
- Antigen Introduction
- The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.
- Alternative Names
- EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
- Gene ID
- 1956
- UniProt ID
- Q504U8
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Related Diseases
Bladder Cancer
Non-small Cell Lung Cancer
Pancreatic Cancer
Hepatocellular Carcinoma
Cushing Syndrome
Related Signaling Pathways
JAK-STAT Signaling Pathway
Downloadable Resources
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Datasheet
MSDS
COA
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