Recombinant Anti-EGFR Vesicular Antibody, EV Displayed (VS-0425-YC340) (CAT#: VS-0425-YC340)

• Application
• ELISA, FC, Neut, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• EGFR

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Human

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Epidermal growth factor receptor

• Biological Process
• Host-virus interaction

• Molecular Function
• Developmental protein, Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase

• Cellular Localization
• Golgi apparatus, Plasma membrane, Nucleoli, Cell Junctions, Primary cilium, Basal body, Cytosol, Mid piece, Principal piece, End piece

• Introduction
• The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.

• Alternative Names
• ERBB, ERBB1, ERRP

• Gene ID
• 1956

• UniProt ID
• P00533

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