EGFR
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: IL2-IgG2a
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG2 - kappa
- Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, IP, FC, FuncS, Neut, IF, IHC
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FC, IP, ELISA, Neut, FuncS, IF, WB
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- Derivation: Chimeric
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
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- Derivation: Humanized (from rat)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, WB
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- Anti-Human EGFR Recombinant Antibody (ABT-806) (TAB-228CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Application: WB, IHC
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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- Derivation: Chimeric (Human/Mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, FC, IF, IHC, FuncS
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- Derivation: Chimeric (human/mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, WB, Inhib
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- Derivation: Humanized
- Species Reactivity: Human
- Type: IgG1
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
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- Rabbit Anti-Human EGFR (phospho Y1092) Antibody (MOB-0242MC)
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- Species Reactivity: Rat, Human
- Application: IHC, WB
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- Human Anti-EGFR Recombinant Antibody (TAB-272MZ) (TAB-272MZ)
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- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: FuncS
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- Human Anti-EGFR Recombinant Antibody (TAB-278MZ) (TAB-278MZ)
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- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, ELISA, Inhib
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- Human Anti-EGFR Recombinant Antibody (TAB-279MZ) (TAB-279MZ)
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- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, ELISA, Inhib
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- Human Anti-EGFR Recombinant Antibody (TAB-274MZ) (TAB-274MZ)
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- Species Reactivity: Human
- Type: Humanized IgG
- Application: FC
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: FuncS
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- Human Anti-EGFR Recombinant Antibody (TAB-0225CL) (TAB-0225CL)
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- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human
- Type: Chimeric (Mouse/Human) IgG1
- Application: Block, Inhib, FuncS, Apop, In vivo
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- Rabbit Anti-Human EGFR (phospho Y1068) Antibody (MOB-0243MC)
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- Species Reactivity: Human, Mouse, Rat
- Application: IHC, WB
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- Human Anti-EGFR Recombinant Antibody (TAB-270MZ) (TAB-270MZ)
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- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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- Human Anti-EGFR Recombinant Antibody (TAB-282MZ) (TAB-282MZ)
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- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, FuncS, Inhib
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- Human Anti-EGFR Recombinant Antibody (TAB-283MZ) (TAB-283MZ)
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- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, FuncS, Inhib
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- Human Anti-EGFR Recombinant Antibody (TAB-284MZ) (TAB-284MZ)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
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- Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-0225CL-F(E)) (TAB-0225CL-F(E))
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- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human
- Type: Chimeric (Mouse/Human) Fab
- Application: Block, Inhib, FuncS, Apop, In vivo
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- Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-270MZ-S(P)) (TAB-270MZ-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-274MZ-S(P)) (TAB-274MZ-S(P))
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- Species Reactivity: Human
- Type: Humanized scFv
- Application: FC
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- Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-272MZ-S(P)) (TAB-272MZ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FuncS
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- Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-0225CL-S(P)) (TAB-0225CL-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: Block, Inhib, FuncS, Apop, In vivo
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- Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-270MZ-F(E)) (TAB-270MZ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-274MZ-F(E)) (TAB-274MZ-F(E))
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: FC
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- Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-278MZ-F(E)) (TAB-278MZ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
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- Recombinant Mouse Anti-EGFR Antibody scFv Fragment (Matuzumab) (PABX-051-S (P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, Neut, FuncS
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- Recombinant Human Anti-EGFR Antibody scFv Fragment (PABX-052-S (P)) (PABX-052-S (P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, FuncS
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- Recombinant Human Anti-EGFR Antibody scFv Fragment (PABX-053-S (P)) (PABX-053-S (P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, FuncS
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- Mouse Anti-EGFR Recombinant Antibody (clone CBL931) (NEUT-723CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP, IHC, ICC, Neut
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- Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-272MZ-F(E)) (TAB-272MZ-F(E))
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- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: FuncS
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- Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-273MZ-F(E)) (TAB-273MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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- Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-275MZ-F(E)) (TAB-275MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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- Anti-Human EGFR Recombinant Antibody Fab Fragment (LA1) (TAB-276MZ-F(E))
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- Application: MTT assay
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- Anti-Human EGFR Recombinant Antibody Fab Fragment (LA22) (TAB-277MZ-F(E))
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- Application: MTT assay
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- Mouse Anti-EGFR Recombinant Antibody (clone 3C10); Fab Fragment (TAB-271MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FuncS
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- Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-273MZ-S(P)) (TAB-273MZ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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- Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-275MZ-S(P)) (TAB-275MZ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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- Anti-Human EGFR Recombinant Antibody scFv Fragment (LA1) (TAB-276MZ-S(P))
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- Application: MTT assay
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- Anti-Human EGFR Recombinant Antibody scFv Fragment (LA22) (TAB-277MZ-S(P))
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- Application: MTT assay
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, WB, FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, WB, FuncS
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- Mouse Anti-EGFR Recombinant Antibody (clone 3C10); scFv Fragment (TAB-271MZ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FuncS
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- Mouse Anti-EGFR Recombinant Antibody (clone 1F8) (TAB-0564CL)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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- Mouse Anti-EGFR Recombinant Antibody (clone 1C5) (TAB-0565CL)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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- Mouse Anti-EGFR Recombinant Antibody (clone 565) (TAB-285MZ)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FuncS
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- Mouse Anti-EGFR Recombinant Antibody (clone 1F8); Fab Fragment (TAB-0564CL-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Mouse Anti-EGFR Recombinant Antibody (clone 1C5); Fab Fragment (TAB-0565CL-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Mouse Anti-EGFR Recombinant Antibody (TAB-275MZ) (TAB-275MZ)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: Cyt, FuncS, Inhib
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- Anti-Human EGFR Recombinant Antibody (LA1) (TAB-276MZ)
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- Application: Cyt, FuncS
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- Anti-Human EGFR Recombinant Antibody (LA22) (TAB-277MZ)
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- Application: Cyt, FuncS
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- Mouse Anti-EGFR Recombinant Antibody (TAB-281MZ) (TAB-281MZ)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IF, IHC
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- Mouse Anti-EGFR Recombinant Antibody (TAB-273MZ) (TAB-273MZ)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, FuncS, IHC, IP, Inhib
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- 10-FnIII scaffold protein anti-Human EGFR (SFN-L003)
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- Scaffold Name: 10-FnIII
- Target: EGFR
- Species Reactivity: Human
- Derivation: Phage display
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- Anti-EGFR Antibody-Cytokine Fusion Protein, IgG-IL2 (ACFP-SH155)
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- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: IgG1-IL2
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- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Chimeric (Mouse-Human)
- Cytokine 1 Species: Human
- Molecule Class: IgG-IL2
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- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: TNFα
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: TNF-IgG2a
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- Scaffold Name: Z-domain of protein A
- Target: EGFR
- Species Reactivity: Human
- Derivation: Phage display
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- Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-037CL)
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- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-038CL)
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- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-EGFR (clone Bat0206)-S-3AA-MDC ADC (ADC-157CL)
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- Target: EGFR
- Linker: S-3AA
- Drug: MDC (maytansinol)
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- Anti-EGFR-mc-MMAF ADC (ADC-039CL)
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- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-EGFR (clone Bat0206)-SMCC-MDC ADC (ADC-158CL)
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- Target: EGFR
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: MDC (maytansinol)
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- Anti-EGFR (clone Antibody 1)-MC-MMAF ADC (ADC-059CL)
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- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-EGFR-vc-PAB-MODO ADC (ADC-263CL)
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- Target: epidermal growth factor receptor (EGFR)
- Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MODO (monomethyldolastatin)
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- Anti-EGFR (clone J2898A)-SMCC-DM1 ADC (ADC-047LZY)
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- Target: EGFR
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Anti-EGFR-Mal-dPEG4-NHS-DM1 ADC (ADC-107LCT)
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- Target: EGFR
- Linker: Mal-dPEG4-NHS
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Anti-EGFRvIII-SMCC-DM1 ADC (ADC-048LZY)
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- Target: EGFRvIII
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Anti-EGFR (MAb806)-Mc-MMAF ADC (ADC-109LCT)
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- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Anti-EGFR-MCC-Dox ADC (ADC-057LZY)
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- Target: EGFR
- Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
- Drug: doxorubicin
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- Anti-EGFR (MAb806)-SMCC-DM1 ADC (ADC-110LCT)
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- Target: EGFR variant III
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Anti-EGFR-EDC/NHS-Dox ADC (ADC-058LZY)
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- Target: EGFR
- Linker: EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
- Drug: doxorubicin
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- Anti-EGFR-SMCC-methotrexate ADC (ADC-059LZY)
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- Target: EGFR
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: MTX
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- Anti-EGFR-doxorubicin ADC (ADC-168LZY)
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- Target: EGFR
- Linker: polyethylene glycol linker
- Drug: doxorubicin
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- Anti-EGFR-EDC/NHS-methotrexate ADC (ADC-060LZY)
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- Target: EGFR
- Linker: EDC/NHS
- Drug: MTX
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- Anti-EGFR (clone ABT-806)-mc-MMAF ADC (ADC-071LZY)
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- Target: EGFR
- Linker: mc (maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
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- Anti-EGFR-vc-Duostatin-3 ADC (ADC-088LZY)
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- Target: EGFR
- Linker: VC (valine-citrulline)
- Drug: Duostatin-3
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For Research Use Only. Not For Clinical Use.
Background
EGFR: Functions as a receptor tyrosine kinase controlling cell growth and differentiation. It activates multiple signaling cascades upon ligand binding. The protein is widely expressed in epithelial tissues. Mutations drive oncogenesis.
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Related Signaling Pathways
JAK-STAT Signaling Pathway
