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EGFR

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The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.

Derivation:
Chimeric (human/mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
FuncS, IF, Neut, ELISA, FC, IP, ICC
Derivation:
Human
Species Reactivity:
Human
Type:
IgG2 - kappa
Application:
ELISA, IP, FC, FuncS, Neut, IF, ICC
Derivation:
Humanized
Species Reactivity:
Human
Type:
IgG1
Application:
Neut, ELISA, IF, IP, FuncS, FC, ICC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
ELISA, IP, FC, FuncS, Neut, IF, IHC
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
ELISA, FC, IP, FuncS, IF, Neut, ICC
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
FC, IP, ELISA, Neut, FuncS, IF, WB
Derivation:
Humanized (from rat)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, WB
Derivation:
Chimeric (mouse/human)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IF, IP, Neut, FuncS, ELISA, FC, ICC
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, IHC, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
IP, RIA, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, IHC, FuncS
Species Reactivity:
Mouse
Type:
Llama VHH
Application:
ELISA, IHC, FC, FuncS
Targets:
EGFR & FcγRIII
Type:
CrossMab
Application:
FuncS, Promising therapeutic agent
Targets:
EGFR & CD3
Type:
BiTE
Application:
FuncS, Promising therapeutic agent
Targets:
EGFR & CD3
Type:
BiTE
Application:
FuncS, Promising therapeutic agent
Targets:
EGFR & FcγRI
Type:
F(ab')2
Application:
FuncS, Promising therapeutic agent
Targets:
FcαRI & EGFR
Type:
F(ab')2
Application:
FuncS, Promising therapeutic agent
Targets:
EGFR & CD2
Type:
F(ab')2
Application:
FuncS, Promising therapeutic agent
Targets:
EGFR & CD28
Type:
F(ab')2
Application:
FuncS, Promising therapeutic agent
Derivation:
Chimeric (Human/Mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, WB
Target:
EGFR
Linker:
MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
Drug:
MMAE (Monomethyl auristatin E)
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