Human Anti-EGFR Recombinant Antibody (clone MR1); Fab Fragment (CAT#: PFBC-040)

Recombinant Human Antibody (MR1) Fab Fragment is specific to EGFRvIII dodecapeptide (EEKKGNYVVTDH), expressed in Chinese Hamster Ovary cells (CHO).


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Figure 1 Cells were allowed to adhere and culture for 48 h before the addition of either 3.2 µmol/L of antisense oligos and/or 2.5 nm of Taxol for a single 24-h treatment, which was then followed by 2 d of additional growth before the addition of WST-1.

Figure 1 Cells were allowed to adhere and culture for 48 h before the addition of either 3.2 µmol/L of antisense oligos and/or 2.5 nm of Taxol for a single 24-h treatment, which was then followed by 2 d of additional growth before the addition of WST-1.

Rubenstein, M., Slobodskoy, L., Mirochnik, Y., & Guinan, P. (2003). Inhibition of PC-3 prostate cancer cell growth in vitro using both antisense oligonucleotides and Taxol. Medical Oncology, 20(1), 29-35.

Figure 2 Cells were allowed to adhere and culture for 48 h before the addition of either 6.64 µmol/L of antisense oligos and/or 5 nm of Taxol for a single 24-h treatment, which was then followed by 2 d of additional growth before the addition of WST-1.

Figure 2 Cells were allowed to adhere and culture for 48 h before the addition of either 6.64 µmol/L of antisense oligos and/or 5 nm of Taxol for a single 24-h treatment, which was then followed by 2 d of additional growth before the addition of WST-1.

Rubenstein, M., Slobodskoy, L., Mirochnik, Y., & Guinan, P. (2003). Inhibition of PC-3 prostate cancer cell growth in vitro using both antisense oligonucleotides and Taxol. Medical Oncology, 20(1), 29-35.


Specifications

  • Immunogen
  • Human epidermal growth factor receptor
  • Host Species
  • Human
  • Type
  • Human Fab
  • Specificity
  • Human EGFR
  • Species Reactivity
  • Human
  • Clone
  • MR1
  • Applications
  • Block

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • The antibody Fab fragment MR1 has been reported in application of Blocking. It's recommended that the optimal antibody concentration, dilution, incubition time etc. are best to be carefully titrated in specific assays.

Target

  • Alternative Names
  • EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone MR1"

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Fc Glycosylation

High-mannose Glycoform

CAT Product Name Application Type
Gly-055LC-1 Recombinant Anti-Human EGFR Antibody (Fc glycosylation/High-mannose glycosylated) ELISA Chimeric antibody (mouse/human)

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-167LC Recombinant Anti-Human EGFR Antibody (Non-glycosylated) ELISA Human antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0183MZ Chicken Anti-EGFR Polyclonal IgY WB Chicken antibody
BRD-0668MZ Chicken Anti-EGFR Polyclonal IgY WB Chicken antibody

Neutralizing Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-165 Afuco™ Anti-EGFR ADCC Recombinant Antibody (Matuzumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody
AFC-TAB-464CQ Afuco™ Anti-EGFR ADCC Recombinant Antibody (Tomuzotuximab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody
AFC-TAB-003 Afuco™ Anti-EGFR ADCC Recombinant Antibody (Cetuximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-040 Afuco™ Anti-EGFR ADCC Recombinant Antibody (Zalutumumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-119 Afuco™ Anti-EGFR ADCC Recombinant Antibody (Necitumumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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