Anti-CD20-CL2A-SN-38 ADC
CAT#: ADC-021LCT
This ADC product is composed of an anti-CD20 antibody conjuagated via a CL2A linker to SN-38 (CL2A-SN-38). It has demonstrated a response in CD20+ B-lymphoma treatment by a MOA (Mechanism of Action) of Inhibit Topoisomerase I and cause DNA damage.







Specifications
- Antibody Overview
- Humanized monoclonal Antibody targeting CD20
- Antibody Isotype
- IgG1κ
- Linker
- CL2A
- Linker Class/Description
- Class: Enzymatically cleavable linker-Peptide linker
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- SN-38 (7-ethyl-10-hydroxycamptothecin)
- Drug Class/Description
- Class: SN-38
Description: SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1
Target
- Introduction
- This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
- Alternative Names
- MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1;
- Gene ID
- 931
- UniProt ID
- A0A024R507
Customer Review
There are currently no Customer reviews or questions for ADC-021LCT. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
See other products for "MS4A1"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-422 | Human Anti-MS4A1 Recombinant Antibody (clone 2F2) | WB, ELISA, FuncS | Human IgG1,κ |
PABL-423 | Mouse Anti-MS4A1 Recombinant Antibody (clone GA101) | FC, Activ, Agonist, IF, WB, Cyt, FuncS | Mouse IgG |
HPAB-0018-FY | Human Anti-MS4A1 Recombinant Antibody (HPAB-0018-FY) | FC | Humanized IgG1 |
HPAB-0021-FY | Human Anti-MS4A1 Recombinant Antibody (HPAB-0021-FY) | FC | Humanized IgG |
HPAB-0742-CN | Human Anti-MS4A1 Recombinant Antibody (HPAB-0742-CN) | ELISA, FC | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1633CL | Anti-Human MS4A1 Recombinant Antibody (ch1F5) | FC, Apop, CDC, ADCC, Inhib | Chimeric antibody (mouse/human) |
TAB-1634CL | Anti-Human MS4A1 Recombinant Antibody (ch1F5-DXL) | FC, Apop, CDC, ADCC, Inhib | Chimeric antibody (mouse/human) |
TAB-1656CL | Anti-Human MS4A1 Recombinant Antibody (ch2B8) | FC, CMCD, ADCC, Activ, Inhib, Depletion | Chimeric antibody (mouse/human) |
TAB-1665CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1665CL) | CDC | Chimeric (mouse/human) IgG |
TAB-1666CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1666CL) | CDC | Chimeric (mouse/human) IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1635CL | Anti-Human MS4A1 Recombinant Antibody (BVX20) | Inhib | Humanized antibody |
TAB-1636CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1636CL) | ADCC, CDC | Humanized IgG |
TAB-1637CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1637CL) | ADCC, CDC | Humanized IgG |
TAB-1638CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1638CL) | ADCC, CDC | Humanized IgG |
TAB-1639CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1639CL) | ADCC, CDC, Apop | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1645CL | Anti-Human MS4A1 Recombinant Antibody (2.1.2) | Cyt, FuncS | Fully human antibody |
TAB-1646CL | Anti-Human MS4A1 Recombinant Antibody (1.1.2) | Cyt, FuncS | Fully human antibody |
TAB-1647CL | Anti-Human MS4A1 Recombinant Antibody (1.5.3) | Cyt, FuncS | Fully human antibody |
TAB-1648CL | Anti-MS4A1 Recombinant Antibody (MEDI-552) | Inhib | |
TAB-1654CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1654CL) | FC, Apop | Human IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-063LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (mouse/human) |
Gly-134LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-135LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-136LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-137LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-138LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Gly-142LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA | Human antibody |
Gly-154LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
Gly-155LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated | ELISA | Humanized antibody |
Gly-158LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-142LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-155LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-171LC | Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC066 | PE-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
MHC-LC067 | APC-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
MHC-LC068 | BV421-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
MHC-LC4347 | PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1751CQ | Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) | Neut, FuncS | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2295 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB) | IHC-Fr, IHC-P | Rabbit IgG |
MOR-4024 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS) | FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0018-FY-S(P) | Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-0018-FY-S(P)) | FC | Humanized scFv |
HPAB-0021-FY-S(P) | Human Anti-MS4A1 Recombinant Antibody scFv Fragment (HPAB-0021-FY-S(P)) | FC | Humanized scFv |
HPAB-0138-WJ-S(P) | Human Anti-MS4A1 Recombinant Antibody (clone L4H7); scFv Fragment | ELISA | Humanized scFv |
HPAB-0139-WJ-S(P) | Human Anti-MS4A1 Recombinant Antibody (clone L4H5); scFv Fragment | ELISA | Humanized scFv |
HPAB-AP384-YC-S(P) | Human Anti-MS4A1 Recombinant Antibody (clone RW005); scFv Fragment | FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0704-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0704-YC) | ELISA, FuncS | Camelid VHH |
HPAB-M0705-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0705-YC) | ELISA | Camelid VHH |
HPAB-M0706-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0706-YC) | ELISA | Camelid VHH |
HPAB-M0707-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0707-YC) | ELISA | Camelid VHH |
HPAB-M0708-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0708-YC) | ELISA | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-772 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-772) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
AFC-TAB-016 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-016) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-028 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-028) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-207 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-207) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
AFC-TAB-771 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-771) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0346-WJ-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone 7F2); Fab Fragment | ELISA | Humanized Fab |
HPAB-0347-WJ-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone 8G3); Fab Fragment | ELISA | Humanized Fab |
HPAB-0614-WJ-F(E) | Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0614-WJ-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0615-WJ-F(E) | Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0615-WJ-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0616-WJ-F(E) | Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0616-WJ-F(E)) | ELISA, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0424-XY188 | AbPlus™ Anti-MS4A1 Magnetic Beads (VS-0424-XY188) | IP, Protein Purification |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0924-YC138 | Human Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC138), CDC Enhanced | FC, CDC, IP | Antibody hexamer |
VS-0924-YC139 | Mouse Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC139), CDC Enhanced | FC, Activ, Agonist, IF, WB, Cyt, CDC | Antibody hexamer |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-1024-XY85 | Mouse Anti-NHP MS4A1 Recombinant Antibody (VS-1024-XY85) | FC | Mouse IgG2b, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0125-FY30 | Human Anti-MS4A1 (clone RW005) scFv-Fc Chimera | FuncS | Human IgG1, scFv-Fc |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0225-XY168 | CytoStream™ Rat Anti-MS4A1 Recombinant Antibody (clone GOT214A) | FC | Rat IgG2a, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-YC513 | Recombinant Anti-MS4A1 Vesicular Antibody, EV Displayed (VS-0425-YC513) | ELISA, FC, Neut, Cell-uptake |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-XY4510 | Anti-MS4A1 Immunohistochemistry Kit | IHC | |
VS-0525-XY4511 | Anti-Mouse MS4A1 Immunohistochemistry Kit | IHC |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-YC129 | Recombinant Anti-MS4A1 (Bin I x Bin II) Biparatopic Antibody, Tandem scFv | ELISA, FC | Tandem scFv |
VS-0525-YC222 | Recombinant Anti-MS4A1 Biparatopic Antibody, Tandem scFv | ELISA, IF, WB | Tandem scFv |
Popular Products
Application: EM, ELISA, ICC, IHC-Fr, IHC-P, WB
Application: Neut, FuncS, IHC, ELISA, FC, Inhib
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: Inhib, Cyt
Application: Neut, ELISA, IF, IP, FuncS, FC, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: WB, ELISA
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: Neut, FuncS, IHC, ELISA, FC, Inhib
Application: EM, ELISA, ICC, IHC-Fr, IHC-P, WB
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: Inhib, Cyt
Application: Neut, ELISA, IF, IP, FuncS, FC, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.