Recombinant Humanized Antibody (Hu5A8) is capable of binding to CD4. This is a humanized IgG4 monoclonal antibody (mAb) derived from a mouse antibody, 5A8, which binds D2 of CD4 and blocks HIV-1 infection in vitro.
Figure 1 Design and characterization of functional BiIAs.
ELISA binding profiles of BiIA-DG and BiIA-SG to human sCD4, compared with IA-PGT128, IA-Hu5A8, and VRC01-IgG. Data represent mean ± SD with duplicates.
Wu, X., Guo, J., Niu, M., An, M., Liu, L., Wang, H., ... & Wang, H. (2018). Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. The Journal of clinical investigation, 128(6), 2239-2251.
Figure 2 Neutralizing activity of BiIA-DG and BiIA-SG.
The graph shows the IC90 values of BiIA-SG compared with parental IA-Hu5A8 against monoresistant viruses. Each pseudovirus was tested in duplicate.
Wu, X., Guo, J., Niu, M., An, M., Liu, L., Wang, H., ... & Wang, H. (2018). Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. The Journal of clinical investigation, 128(6), 2239-2251.
Figure 3 Design and characterization of 5 IAs.
The released IAs in culture supernatants were detected by Western blot analysis under reducing conditions.
Wu, X., Guo, J., Niu, M., An, M., Liu, L., Wang, H., ... & Wang, H. (2018). Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. The Journal of clinical investigation, 128(6), 2239-2251.
Figure 4 Design and characterization of 5 IAs.
Each IA displayed neutralizing activity against pseudovirus HIV-1ADA.
Wu, X., Guo, J., Niu, M., An, M., Liu, L., Wang, H., ... & Wang, H. (2018). Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. The Journal of clinical investigation, 128(6), 2239-2251.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-039 | Anti-Human CD4 Recombinant Antibody (Zanolimumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-171 | Anti-Human CD4 Recombinant Antibody (Keliximab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - lambda |
TAB-732 | Anti-CD4 Recombinant Antibody (Clenoliximab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG4 - lambda |
TAB-167LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (cM-T412) | ELISA | Chimeric antibody (mouse/human) |
TAB-170LC-S(P) | Rat Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-170LC-S(P)) | ELISA, SPR | Rat scFv |
TAB-170LC-F(E) | Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-170LC-F(E)) | ELISA, SPR | Chimeric antibody (rat/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G078E | Anti-CD4 immunotoxin M-T151 (IgG)-PE | Cytotoxicity assay, Function study | |
AGTO-G078R | Anti-CD4 immunotoxin M-T151 (IgG)-RTA | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-160LC | Anti-Human CD4 Recombinant Antibody (OKT4A) | ELISA, WB | |
TAB-166LC | Anti-Human CD4 Recombinant Antibody (M-T412) | ELISA, Inhib | |
TAB-173LC | Anti-Human CD4 Recombinant Antibody (IgA F425-Alg8) | ELISA, Inhib | |
TAB-175LC-F(E) | Anti-Human CD4 Recombinant Antibody Fab Fragment (15A7) | FC, ELISA | |
TAB-176LC-F(E) | Anti-Human CD4 Recombinant Antibody Fab Fragment (14G7) | FC, ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-161LC | Anti-Human CD4 Recombinant Antibody (gOKT4A-4) | ELISA | Humanized antibody |
TAB-168LC | Anti-Human CD4 Recombinant Antibody (TRX1) | ELISA | Humanized antibody |
TAB-171LC | Human Anti-CD4 Recombinant Antibody (TAB-171LC) | ELISA, FC, SPR | Humanized antibody |
TAB-172LC | Human Anti-CD4 Recombinant Antibody (TAB-172LC) | ELISA, Inhib | Human IgG |
TAB-161LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (gOKT4A-4) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-025LC | Recombinant Anti-Human CD4 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-351CQ | Mouse Anti-CD4 Recombinant Antibody (clone 10C12) | ELISA, WB, IF, Block | Mouse IgG1 |
NEUT-352CQ | Mouse Anti-CD4 Recombinant Antibody (clone 13B8.2) | Block, ELISA, FC, IHC-Fr, WB | Mouse IgG1, κ |
NEUT-355CQ | Mouse Anti-CD4 Recombinant Antibody (clone RPA-T4) | FC, CyTOF, Block, IHC | Mouse IgG1, κ |
NEUT-357CQ | Rat Anti-CD4 Recombinant Antibody (clone MAB0810) | Block, Depletion, Stim | Rat IgG2b |
NEUT-358CQ | Rat Anti-CD4 Recombinant Antibody (clone RM4-5) | FC, CyTOF, Depletion, Block, IHC | Rat IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-353CQ | Mouse Anti-CD4 Recombinant Antibody (clone CBL976) | FC, Neut, IF, IHC | Mouse IgG1, κ |
NEUT-354CQ | Recombinant Mouse Anti-CD4 Antibody (CT-4) | Neut, FC, IHC, IHC-Fr, IHC-P, IP | IgG1, κ |
NEUT-356CQ | Mouse Anti-CD4 Recombinant Antibody (clone 3-4F4) | Neut, FC, IHC, IHC-Fr, IP, ICC | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0560 | Hi-Affi™ Rabbit Anti-CD4 Recombinant Antibody (clone DS560AB) | IHC-P | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0758-CN-F(E) | Human Anti-CD4 Recombinant Antibody (clone Variant B); Fab Fragment | ELISA, FC | Human Fab |
HPAB-0759-CN-F(E) | Human Anti-CD4 Recombinant Antibody (clone Variant D); Fab Fragment | ELISA, FC | Human Fab |
HPAB-0792-CN-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone B4); Fab Fragment | ELISA | Mouse Fab |
HPAB-0793-CN-F(E) | Human Anti-CD4 Recombinant Antibody (clone chB4); Fab Fragment | ELISA | Chimeric (mouse/human) Fab |
HPAB-0794-CN-F(E) | Human Anti-CD4 Recombinant Antibody (clone dB4C7); Fab Fragment | ELISA | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0135CQ-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-0135CQ-S(P)) | ELISA, FuncS | Human scFv |
HPAB-0295-FY-S(P) | Mouse Anti-CD4 Recombinant Antibody (clone CBLC-005); scFv Fragment | WB, IHC, FC | Mouse scFv |
HPAB-0957WJ-S(P) | Human Anti-CD4 Recombinant Antibody (clone 4-91); scFv Fragment | ELISA | Human scFv |
HPAB-1110WJ-S(P) | Mouse Anti-CD4 Recombinant Antibody (clone KCLRF-BP-00211); scFv Fragment | FC, IHC | Mouse scFv |
HPAB-2112-FY-S(P) | Mouse Anti-CD4 Recombinant Antibody (clone MT15.1); scFv Fragment | Inhib | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1750-CN | Rabbit Anti-CD4 Polyclonal Antibody (MRO-1750-CN) | WB, IF, IHC, FC | Rabbit IgG |
MRO-1751-CN | Rabbit Anti-CD4 Polyclonal Antibody (MRO-1751-CN) | WB, IF, IHC, FC | Rabbit IgG |
MRO-1752-CN | Rabbit Anti-CD4 Polyclonal Antibody (MRO-1752-CN) | WB, IF, IHC, FC | Rabbit IgG |
FN-244CQ | Mouse Anti-CD4 Recombinant Antibody (clone OKT4 (OKT-4)) | FC, FuncS, IP | Mouse IgG2b, κ |
HPAB-2059LY | Mouse Anti-CD4 Recombinant Antibody (HPAB-2059LY) | FC | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-039 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Zanolimumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-164 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Priliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-260 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Tregalizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-171 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Keliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-107 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Cedelizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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