Anti-GD2 Immunocytokine, IgG (ch14.18)-RLI (ACFP-SH143)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-GD2 IgG to RLI. It was expressed in CHO and purified with affinity chromatography. Anti-GD2-RLI fully retained the cytokine potential of RLI and the antibody effector functions (antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity). It displayed strong antitumor activities in two syngeneic cancer models in immunocompetent mice (subcutaneous EL4 and metastatic NXS2). This immunocytokine was designed for treating GD2-positive tumors.      

Molecule Class
L Kappa; IgG2-RLI
Species Reactivity
Chimeric (Human-Mouse)
Expression Host
Related Disease
GD2-positive tumors
Cytokines 1
Cytokines 1 Description
ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumor cell proliferation and antiapoptosis.
Cytokine 1 Species
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Alternative Names
Disialoganglioside GD2; Ganglioside G2; GD2

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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