Anti-GD2 Antibody-Cytokine Fusion Protein, IgG (ch14.18)-RLI
CAT#: ACFP-SH143
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-GD2 IgG to RLI. It was expressed in CHO and purified with affinity chromatography. Anti-GD2-RLI fully retained the cytokine potential of RLI and the antibody effector functions (antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity). It displayed strong antitumor activities in two syngeneic cancer models in immunocompetent mice (subcutaneous EL4 and metastatic NXS2). This immunocytokine was designed for treating GD2-positive tumors.
Specifications
- Target
- GD2
- Molecule Class
- L Kappa; IgG2-RLI
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- ch14.18
- Related Disease
- GD2-positive tumors
- Cytokine 1
- RLI
- Cytokines 1 Description
- ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumor cell proliferation and antiapoptosis.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Disialoganglioside GD2; Ganglioside G2; GD2
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Datasheet
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See other products for "Clone ch14.18"
- CAT
- Product Name
See other products for "GD2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-770-sdAb | Recombinant Anti-Human GD2 VHH Single Domain Antibody | Neut, ChiP, IP, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-731 | Anti-GD2 Recombinant Antibody (TAB-731) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L018R | anti-GD2 immunotoxin 14G2a (IgG)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-304CL | Anti-Human GD2 Recombinant Antibody (hu14.18K322A) | FC, FuncS | Antibody |
| PABX-059 | Human Anti-GD2 Recombinant Antibody (PABX-059) | FuncS | IgG1, κ |
| PABX-059-F (E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (PABX-059-F (E)) | FC, ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-100 | Mouse Anti-GD2 Recombinant Antibody (clone 14G2a) | ELISA, WB, FuncS | Mouse IgG |
| PABZ-049 | Mouse Anti-GD2 Recombinant Antibody (clone ME36.1) | WB, FuncS | Mouse IgG |
| HPAB-0027-WJ | Mouse Anti-GD2 Recombinant Antibody (HPAB-0027-WJ) | ELISA, RIA | Mouse IgG3, κ |
| HPAB-1524WJ | Human Anti-GD2 Recombinant Antibody (clone KM8138) | ELISA, WB | Human IgG |
| HPAB-1525WJ | Human Anti-GD2 Recombinant Antibody (clone KM1138) | ELISA, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-100 | Mouse Anti-GD2 Recombinant Antibody (clone 14G2a); scFv Fragment | ELISA, WB, FuncS | Mouse scFv |
| PSBL-101 | Mouse Anti-GD2 Recombinant Antibody (clone 3F8); scFv Fragment | FC, ELISA, FuncS | Mouse scFv |
| PSBZ-049 | Mouse Anti-GD2 Recombinant Antibody (clone ME36.1); scFv Fragment | WB, FuncS | Mouse scFv |
| HPAB-1030WJ-S(P) | Mouse Anti-GD2 Recombinant Antibody; scFv Fragment (HPAB-1030WJ-S(P)) | ELISA | Mouse scFv |
| HPAB-1524WJ-S(P) | Human Anti-GD2 Recombinant Antibody; scFv Fragment (clone KM8138) | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-100 | Mouse Anti-GD2 Recombinant Antibody (clone 14G2a); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
| PFBZ-049 | Mouse Anti-GD2 Recombinant Antibody (clone ME36.1); Fab Fragment | WB, FuncS | Mouse Fab |
| FAMAB-0126-YC-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 7A4); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0701-CN-F(E) | Human Anti-GD2 Recombinant Antibody (clone AB527); Fab Fragment | ELISA, FC, IHC, IF | Human Fab |
| HPAB-1030WJ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (HPAB-1030WJ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-074CQ | Human Anti-GD2 Recombinant Antibody (TAB-074CQ) | ELISA, FC | Human IgG1, κ |
| TAB-076CQ | Human Anti-GD2 Recombinant Antibody (TAB-076CQ) | ELISA, FC | Human IgG1, κ |
| TAB-077CQ | Human Anti-GD2 Recombinant Antibody (TAB-077CQ) | ELISA, FC | Human IgG1, κ |
| TAB-078CQ | Human Anti-GD2 Recombinant Antibody (TAB-078CQ) | ELISA, FC | Human IgG1, κ |
| TAB-074CQ-S(P) | Human Anti-GD2 Recombinant Antibody; scFv Fragment (TAB-074CQ-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-075CQ | Human Anti-GD2 Recombinant Antibody (TAB-075CQ) | ELISA, FC | Human IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-029CN | Mouse Anti-GD2 Recombinant Antibody (clone 5F11) | WB | Mouse IgG |
| NS-030CN | Mouse Anti-GD2 Recombinant Antibody (clone 3G6) | WB | Mouse IgG |
| NS-029CN-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 5F11); Fab Fragment | WB | Mouse Fab |
| NS-030CN-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 3G6); Fab Fragment | WB | Mouse Fab |
| NS-029CN-S(P) | Mouse Anti-GD2 Recombinant Antibody (clone 5F11); scFv Fragment | WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-731 | Afuco™ Anti-GD2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-731) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY63 | Human Anti-GD2 (clone 3F8) scFv-Fc Chimera | FC, ELISA, FuncS, ADCC, Cyt | Human IgG1, scFv-Fc |
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