Anti-GD2 Antibody-Cytokine Fusion Protein, IgG (ch14.18)-RLI (CAT#: ACFP-SH143)

• Target
• GD2

• Molecule Class
• L Kappa; IgG2-RLI

• Species Reactivity
• Human

• Expression Host
• CHO

• Clone
• ch14.18

• Related Disease
• GD2-positive tumors

• Cytokine 1
• RLI

• Cytokines 1 Description
• ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumor cell proliferation and antiapoptosis.

• Cytokine 1 Species
• Human

• Applications
• This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Alternative Names
• Disialoganglioside GD2; Ganglioside G2; GD2

• ACFP-SH019
• Anti-GD2 Antibody-Cytokine Fusion Protein, IgG (ch14.18)-IL2

• ACFP-SH020
• Anti-GD2 Antibody-Cytokine Fusion Protein, IgG (ch14.18)-LT

• ACFP-SH144
• Anti-GD2 Antibody-Cytokine Fusion Protein, IgG (ch14.18)-TNFα

• ACFP-SH021
• Anti-GD2 Antibody-Cytokine Fusion Protein, IgG (ch14.18)-GM-CSF

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