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    Anti-HCV E2 Recombinant Antibody (e509) (CAT#: MRO-1204LC)

    This product is a recombinant human anti-Hepatitis C virus monoclonal antibody (e509). e509 directed against the 436-447 region (epitope II) of HCV/E2 glycoprotein.e509 specifically binds to glycoprotein E2 associated with HCV and can be potentially used in the treatment and diagnosis of Hepatitis C virus infection.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Published Data
    • Datasheet
    • MSDS
    • COA
    Neut

    Figure 1 Critical residues abrogating mAb binding.

    Figure 1 Critical residues abrogating mAb binding.

    Antibodies are divided into neutralizers and non-neutralizers. Epitope residues are marked in red, while residues that are part of the CD81bs are underlined. The threshold below which a decrease in reactivity defines a residue as part of an epitope was determined for each antibody (e137 < 15%, e20 < 20%, e301 < 20%, e509 < 15%, e10 < 30%, e8 < 20%, H60 < 15%).

    A Biologically-validated HCV E1E2 Heterodimer Structural Model

    Neut

    Figure 2 Inhibition of binding of probe FLAG-Fab antigen by previous binding of different concentrations of purified unlabeled Fabs used as competitors.

    Figure 2 Inhibition of binding of probe FLAG-Fab antigen by previous binding of different concentrations of purified unlabeled Fabs used as competitors.

    Mapping B-Cell Epitopes of Hepatitis C Virus E2 Glycoprotein Using Human Monoclonal Antibodies from Phage Display Libraries

    Neut

    Figure 3 Inhibition of binding of human recombinant Fabs by previous binding of a 1:20 dilution of sera obtained from HCV-infected patients and from two HCV-negative controls.

    Figure 3 Inhibition of binding of human recombinant Fabs by previous binding of a 1:20 dilution of sera obtained from HCV-infected patients and from two HCV-negative controls.

    All HCV-positive sera were demonstrated to contain HCV RNA of genotype 1b and to have an ELISA titer against HCV/E2 of>1:500.


    Specifications

    • Host Species
    • Human
    • Type
    • Human antibody
    • Specificity
    • Hepatitis C virus
    • Clone
    • e509
    • Applications
    • ELISA, Neut
    • Related Disease
    • Hepatitis C virus infection

    Applications

    • Application Notes
    • The HCV E2 Protein antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Neutralization.

    Target

    • Alternative Names
    • Hepatitis C virus; HCV; HCV E2; Hepatitis C virus E2

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    See other products for "Clone e509"

    See other products for "HCV E2 protein"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    IgG Antibody Products Human Antibody Products Chimeric Antibody Products Humanized Antibody Products Mouse Antibody Products MHC Tetramer Products for Virology Epitope-Specific Antibody Products Fab Antibody Products ScFv Antibody Products Antibody Magnetic Beads
    CAT Product Name Application Type
    MHH-446 Recombinant Human Anti-HCV E2 Antibody FC, WB, FuncS IgG
    PABL-495 Mouse Anti-HCV E2 Protein Recombinant Antibody (PABL-495) ELISA, Neut Mouse IgG
    PABL-496 Recombinant Mouse Anti-HCV E2 Antibody (AP33) FC, Neut, FuncS IgG
    FAMAB-0586WJ Human Anti-HCV E2 Recombinant Antibody (clone #37) ELISA, WB, Neut, IF Human IgG1, κ
    FAMAB-0587WJ Human Anti-HCV E2 Recombinant Antibody (clone #55) ELISA, WB, Neut, IF Human IgG1, λ

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    For Research Use Only. Not For Clinical Use.

    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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