Anti-HIV-1 antibody is a Human antibody of IgG3 λ class that binds to an HIV-1. This antibody recognizes the hypervariable gp120 V3 loop, and neutralizes both X4 and R5 primary isolates, making it one of the most effective anti-V3 antibodies characterized to date.
Figure 1 Binding of the mutated 447-52D IgG to the indicated gp140 trimers as measured by ELISA.
McGuire, A. T., Glenn, J. A., Lippy, A., & Stamatatos, L. (2014). Diverse recombinant HIV-1 Envs fail to activate B cells expressing the germline B cell receptors of the broadly neutralizing anti-HIV-1 antibodies PG9 and 447-52D. Journal of virology, 88(5), 2645-2657.
Figure 2 The area under the curve of the Ca2 flux response (determined in panel C) through the mutated 447-52D BCR correlates with the affinity of sIgG 447-52D (determined in panel A).
McGuire, A. T., Glenn, J. A., Lippy, A., & Stamatatos, L. (2014). Diverse recombinant HIV-1 Envs fail to activate B cells expressing the germline B cell receptors of the broadly neutralizing anti-HIV-1 antibodies PG9 and 447-52D. Journal of virology, 88(5), 2645-2657.
Figure 3 Neutralization of chimeric psVs by antibodies 447-52D (purple) and 2219 (blue).
The psV consist of the SF162 strain with its V3 loop replaced by the indicated V3 loop sequence. Consensus B-R18Q is a psV consisting of the consensus subtype B V3 loop sequence with position 18 in the V3 loop mutated from a subtype B consensus arginine to a subtype C consensus glutamine. IC50 is the amount of antibody in ug/mL required to achieve 50% neutralization.
The negative base 10 logarithm of the IC50 has been plotted
for easier comparison: higher, positive bars towards the top of the
graph indicate strong neutralization by the antibody. Antibodies
were only tested to a concentration of 20 ug/mL for neutralization,
so the negative value of 1.3 on the plot is maximal and indicated no
detectable neutralization by the antibody
Almond, D., Krachmarov, C., Swetnam, J., Zolla-Pazner, S., & Cardozo, T. (2012). Resistance of subtype C HIV-1 strains to anti-V3 loop antibodies. Advances in virology, 2012.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
NABG-082 | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBW-160 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone F105); scFv Fragment | FC, Neut | Human scFv |
PSBW-178 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone b12); scFv Fragment | Neut, ELISA | Human scFv |
FAMAB-0177CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone BAT123); Fab Fragment | Neut | Chimeric (mouse/human) Fab |
FAMAB-0178CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone C beta 1); Fab Fragment | WB, Neut | Chimeric (mouse/human) Fab |
MRO-3015CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 212A (2.12A)); Fab Fragment | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-005LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-005LC) | ELISA | Human IgG1 |
MRO-006LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-006LC) | ELISA | Human IgG1 |
MRO-007LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-007LC) | ELISA | Human IgG1 |
MRO-011LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-011LC) | ELISA | Human IgG1 |
MRO-012LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-012LC) | ELISA | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-041LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (D59/A2) | ELISA | Mouse antibody |
MRO-042LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (F58/H3) | ELISA | Mouse antibody |
MRO-043LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (P1/D12) | ELISA | Mouse antibody |
MRO-044LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (P4/D10) | ELISA | Mouse antibody |
MRO-045LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (A47/B1) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3640CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone Chessie 6) | ELISA, WB | Mouse IgG |
MRO-3641CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 101-342) | ELISA, WB | Mouse IgG2a, κ |
MRO-3642CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 101-451) | ELISA, WB | Mouse IgG2b, κ |
MRO-3643CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 105-518) | ELISA, WB | Mouse IgG1, κ |
MRO-3644CQ | Rat Anti-HIV-1 gp120 Recombinant Antibody (clone ICR 39.13g (ICR39.13g, 39.13g, ICR39.13)) | Neut | Rat IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3347CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC26.04 (CAP256-VRC26.04)); scFv Fragment | ELISA, Neut | Human scFv |
MRO-3348CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 4210); scFv Fragment | Neut | Human scFv |
MRO-3530CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 13A2); scFv Fragment | ELISA | Humanized scFv |
MRO-3531CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 13C); scFv Fragment | ELISA | Humanized scFv |
MRO-3532CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 6A); scFv Fragment | ELISA | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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