Afuco™ Anti-Human Hla ADCC Recombinant Antibody (MEDI4893), ADCC Enhanced (CAT#: AFC-343CL)
Anti-Hla ADCC Enhanced Antibody (MEDI4893) is an ADCC enhanced antibody produced by our Afuco™ platform. MEDI4893 is a neutralizing human monoclonal antibody that targets α-toxin (AT) and is currently undergoing evaluation in the field of Staphylococcus aureus-mediated diseases. In particular, MEDI4893 not only sterically blocks binding of AT to its cell receptor but also prevents it from adopting a lytic heptameric trans-membrane conformation.
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Figure 4 MEDI4893 pharmacokinetics in healthy adult volunteers. Dashed line represents the target concentration of 211 µg/mL, the EC90 from a S. aureus murine pneumonia model.
Yu, X. Q., Robbie, G. J., Wu, Y., Esser, M. T., Jensen, K., Schwartz, H. I., ... & Jafri, H. S. (2017). Safety, tolerability, and pharmacokinetics of MEDI4893, an investigational, extended-half-life, anti-Staphylococcus aureus alpha-toxin human monoclonal antibody, in healthy adults. Antimicrobial agents and chemotherapy, 61(1), e01020-16.
Figure 5 (A) Baseline serum anti‒alpha-toxin neutralizing antibody. (B) Correlation between serum MEDI4893 concentrations and anti‒alpha-toxin neutralizing activity. AT = alpha-toxin.
Yu, X. Q., Robbie, G. J., Wu, Y., Esser, M. T., Jensen, K., Schwartz, H. I., ... & Jafri, H. S. (2017). Safety, tolerability, and pharmacokinetics of MEDI4893, an investigational, extended-half-life, anti-Staphylococcus aureus alpha-toxin human monoclonal antibody, in healthy adults. Antimicrobial agents and chemotherapy, 61(1), e01020-16.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- S. aureus pneumonia
Product Property
- Purity
- Purity>95% by SDS-PAGE
- Storage
- ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C
Target
- Alternative Names
- Staphylococcus aureus alpha toxin; Hla; Alpha-toxin; alpha-hemolysin
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Human Antibody Products
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-358CL | Anti-Human Hla Recombinant Antibody (TAB-358CL) | FuncS, Neut | Antibody |
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