Afuco™ Anti-Human Hla ADCC Recombinant Antibody (MEDI4893), ADCC Enhanced (CAT#: AFC-343CL)
Anti-Hla ADCC Enhanced Antibody (MEDI4893) is an ADCC enhanced antibody produced by our Afuco™ platform. MEDI4893 is a neutralizing human monoclonal antibody that targets α-toxin (AT) and is currently undergoing evaluation in the field of Staphylococcus aureus-mediated diseases. In particular, MEDI4893 not only sterically blocks binding of AT to its cell receptor but also prevents it from adopting a lytic heptameric trans-membrane conformation.
Specific Inquiry
Figure 4 MEDI4893 pharmacokinetics in healthy adult volunteers. Dashed line represents the target concentration of 211 µg/mL, the EC90 from a S. aureus murine pneumonia model.
Yu, X. Q., Robbie, G. J., Wu, Y., Esser, M. T., Jensen, K., Schwartz, H. I., ... & Jafri, H. S. (2017). Safety, tolerability, and pharmacokinetics of MEDI4893, an investigational, extended-half-life, anti-Staphylococcus aureus alpha-toxin human monoclonal antibody, in healthy adults. Antimicrobial agents and chemotherapy, 61(1), e01020-16.
Figure 5 (A) Baseline serum anti‒alpha-toxin neutralizing antibody. (B) Correlation between serum MEDI4893 concentrations and anti‒alpha-toxin neutralizing activity. AT = alpha-toxin.
Yu, X. Q., Robbie, G. J., Wu, Y., Esser, M. T., Jensen, K., Schwartz, H. I., ... & Jafri, H. S. (2017). Safety, tolerability, and pharmacokinetics of MEDI4893, an investigational, extended-half-life, anti-Staphylococcus aureus alpha-toxin human monoclonal antibody, in healthy adults. Antimicrobial agents and chemotherapy, 61(1), e01020-16.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- S. aureus pneumonia
Product Property
- Purity
- Purity>95% by SDS-PAGE
- Storage
- ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C
Target
- Alternative Names
- Staphylococcus aureus alpha toxin; Hla; Alpha-toxin; alpha-hemolysin
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Human Antibody Products
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-358CL | Anti-Human Hla Recombinant Antibody (TAB-358CL) | FuncS, Neut | Antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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