Anti-Human VEGFR-1 Recombinant Antibody (Icrucumab) (CAT#: TAB-177)

Recombinant monoclonal antibody to VEGFR-1. Icrucumab is a human monoclonal antibody designed for the treatment of solid tumors.


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ELISA

Figure 1 Anti-VEGFR-1 Recombinant Antibody (TAB-177) in ELISA

Figure 1 Anti-VEGFR-1 Recombinant Antibody (TAB-177) in ELISA

ELISA analysis of TAB-177 was performed by coating with human VEGFR-1 protein (His tag). Then blocked with BSA and incubated with TAB-177. A HRP-conjugated goat anti-human IgG was used as the secondary antibody (1: 2000). Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.

WB

Figure 2 Anti-VEGFR-1 Recombinant Antibody (TAB-177) in WB

Figure 2 Anti-VEGFR-1 Recombinant Antibody (TAB-177) in WB

Western blot analysis of TAB-177 was performed by loading human VEGFR-1 protein (Lane 1 0.1 μg, Lane 2 0.3 μg, Lane 3 0.6 μg) onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-177 and a HRP goat anti-human IgG (H+L) was used as the secondary antibody (1: 3000). Chemiluminescent detection was performed.

DB

Figure 3 Anti-VEGFR-1 Recombinant Antibody (TAB-177) in DB

Figure 3 Anti-VEGFR-1 Recombinant Antibody (TAB-177) in DB

Dot Blot analysis of TAB-177 was performed by coating with human VEGFR-1 protein (His tag).
TAB-177 incubation concentration: 2 μg/mL.
HRP-conjugated goat anti-human IgG (H+L) secondary antibody (1: 3000)
NC: Negative control, PC: Positive control


Specifications

  • Immunogen
  • Recombinant human soluble extracellular Flt-1 Ig-like loop 1 to 5 (sFlt-1(D5)).
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG1 - kappa
  • Specificity
  • Tested positive against native human antigen.
  • Species Reactivity
  • Human
  • Applications
  • Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
  • CAS
  • 1024603-92-6
  • Generic Name
  • Icrucumab
  • UNII
  • T7H0B1R64U
  • MW
  • 146.8 kDa
  • Related Disease
  • Colon cancers

Product Property

  • Purity
  • >95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Target

  • Alternative Names
  • Icrucumab;1024603-92-6;IMC-18F1;IMC18F1;FLT1;fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor);FLT;vascular endothelial growth factor receptor 1;VEGFR1;FLT-1;VEGFR-1;fms-like tyrosine kinase 1;tyrosin

Related Resources

  • Biosimilar Overview
  • Related Diseases
Please refer to Icrucumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Icrucumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Icrucumab"

Afuco™ Anti-FLT1 ADCC Recombinant Antibody (Icrucumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to VEGFR-1. Icrucumab is a human monoclonal antibody designed for the treatment of solid tumors.

See other products for "FLT1"

Chimeric Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-845CQ Mouse Anti-FLT1 Recombinant Antibody (clone MAB0702) WB, Block Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1322 Hi-Affi™ Rabbit Anti-FLT1 Recombinant Antibody (clone DS1322AB) WB, IHC-P, ICC, IF, IP, ELISA, IHC-P, IHC-Fr Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-177 Afuco™ Anti-FLT1 ADCC Recombinant Antibody (Icrucumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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