Anti-Dabigatran Recombinant Antibody (Idarucizumab) (CAT#: TAB-H40)
Recombinant Humanized antibody to dabigatran
Specific Inquiry
Figure 1 Pharmacokinetic data.
Geometric mean idarucizumab plasma concentration-time profiles from the start of a single infusion of 1 g to 4 g idarucizumab for 5 minutes on (A) a linear scale and (B) a semi-log scale.
Reilly, P. A., van Ryn, J., Grottke, O., Glund, S., & Stangier, J. (2016). Idarucizumab, a specific reversal agent for dabigatran: mode of action, pharmacokinetics and pharmacodynamics, and safety and efficacy in phase 1 subjects. The American journal of medicine, 129(11), S64-S72.
Figure 2 Effect of idarucizumab or placebo infusion on coagulation variables, (A) dTT, (B) ECT, (C) aPTT and (D) TT.
Dotted horizontal lines show upper limit of normal. "0 h" and the arrows on x axes show when the idarucizumab or placebo infusion ended. Solid horizontal lines show the mean baseline measurement. Data points show mean; error bars show standard error. aPTT = activated partial thromboplastin time; DE = dabigatran etexilate; dTT = diluted thrombin time; ECT = ecarin clotting time.
Reilly, P. A., van Ryn, J., Grottke, O., Glund, S., & Stangier, J. (2016). Idarucizumab, a specific reversal agent for dabigatran: mode of action, pharmacokinetics and pharmacodynamics, and safety and efficacy in phase 1 subjects. The American journal of medicine, 129(11), S64-S72.
Specifications
- Host Species
- undefined
- Derivation
- Humanized
- Type
- Fab - G1 - kappa
- Specificity
- dabigatran etexilate mesylate (Pradaxa®)
- Species Reactivity
- N/A
- Applications
- IP, IF, FuncS, FC, Neut, ELISA, IHC, PK, Activ
- CAS
- 1362509-93-0
- Generic Name
- idarucizumab
- MW
- 47.8 kDa
- Related Disease
- Overdose of dabigratran etexilate mesylate (Pradaxa®)(an oral anticoagulant, direct thrombin inhibitor)
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Applications
- Application Notes
- The dabigatran antibody has been reported in applications of IP, IF, FuncS, FC, Neut, ELISA, IHC, PK, Activ.
Target
- Alternative Names
- idarucizumab;1362509-93-0;dabigatran;Pradaxa;Pradax;Prazaxa
Related Resources
Please refer to Idarucizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Idarucizumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "dabigatran"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-167 | Mouse Anti-Dabigatran Recombinant Antibody (clone 15C9) | ELISA, Neut | Mouse IgG |
| HPAB-1507-FY | Human Anti-Dabigatran Recombinant Antibody (HPAB-1507-FY) | Neut, ELISA | Chimeric (mouse/human) IgG |
| HPAB-1508-FY | Human Anti-Dabigatran Recombinant Antibody (HPAB-1508-FY) | Neut, ELISA | Chimeric (mouse/human) IgG |
| HPAB-1509-FY | Human Anti-Dabigatran Recombinant Antibody (HPAB-1509-FY) | Neut, ELISA | Chimeric (mouse/human) IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-167 | Mouse Anti-Dabigatran Recombinant Antibody (clone 15C9); Fab Fragment | ELISA, Neut | Mouse Fab |
| HPAB-1507-FY-F(E) | Mouse Anti-Dabigatran Recombinant Antibody; Fab Fragment (HPAB-1507-FY-F(E)) | Neut, ELISA | Mouse Fab |
| HPAB-1508-FY-F(E) | Mouse Anti-Dabigatran Recombinant Antibody; Fab Fragment (HPAB-1508-FY-F(E)) | Neut, ELISA | Mouse Fab |
| HPAB-1509-FY-F(E) | Mouse Anti-Dabigatran Recombinant Antibody; Fab Fragment (HPAB-1509-FY-F(E)) | Neut, ELISA | Mouse Fab |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-167 | Mouse Anti-Dabigatran Recombinant Antibody (clone 15C9); scFv Fragment | ELISA, Neut | Mouse scFv |
| HPAB-1507-FY-S(P) | Mouse Anti-Dabigatran Recombinant Antibody; scFv Fragment (HPAB-1507-FY-S(P)) | Neut, ELISA | Mouse scFv |
| HPAB-1508-FY-S(P) | Mouse Anti-Dabigatran Recombinant Antibody; scFv Fragment (HPAB-1508-FY-S(P)) | Neut, ELISA | Mouse scFv |
| HPAB-1509-FY-S(P) | Mouse Anti-Dabigatran Recombinant Antibody; scFv Fragment (HPAB-1509-FY-S(P)) | Neut, ELISA | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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